Current treatment approaches for COVID-19 and the clinical value of transfusion-related technologiesReview article Published on 2020-10-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] SARS, 치료법, [키워드] antiviral therapy Beta Blood caused Clinical practice convalescent plasma coronavirus COVID-19 COVID-19 infection current disease Health Immunomodulatory agents Infection Intervention mesenchymal stem cell Numerous patients with COVID-19 Plasmapheresis potential therapies SARS-CoV-2 specific treatment Therapeutic approach Treatment treatment approach virus [DOI] 10.1016/j.transci.2020.102839 [Article Type] Review article
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19Case Reports Published on 2020-10-012023-07-11 Journal: Frontiers of medicine [Category] SARS, [키워드] acute respiratory distress syndrome Coronavirus disease 2019 (COVID-19) mesenchymal stem cell stem cell therapeutics. [DOI] 10.1007/s11684-020-0810-9 PMC 바로가기 [Article Type] Case Reports
Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19Article Published on 2020-09-292023-07-05 Journal: Drug design, development and therapy [Category] SARS, [키워드] COVID-19 immunomodulation mesenchymal stem cell tissue regeneration [DOI] 10.2147/DDDT.S269407 PMC 바로가기
The role of mesenchymal stromal cells in immune modulation of COVID-19: focus on cytokine stormReview Published on 2020-09-182022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, [키워드] activities acute respiratory distress acute respiratory illness adaptive administration ARDS cause contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 patients Cytokine storm death homogenous Immune cell immune modulation Immune regulatory immune response immune systems immunoregulatory property Immunosuppression IMPROVE Inflammation Interaction Lung function mesenchymal stem cell Mesenchymal stromal cells MSC MSCs outbreak pandemic Pathogenesis Pathogens pathology patients patients with COVID-19 populations produced pulmonary fibrosis reduce research finding responsible SARS-CoV-2 stem cell stromal cell Symptoms syndrome the cytokine storm these cell tissue tissues virus [DOI] 10.1186/s13287-020-01849-7 PMC 바로가기 [Article Type] Review
State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol DeliveryReview Published on 2020-09-032022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acute respiratory distress administration aerosol Anti-inflammatory ARDS ATMP cause Cell chronic obstructive clinically conditioned media COPD COVID-19 death delivery disease Diseases effective exhibited Exosomes incurable longitudinal study lung mesenchymal stem cell MSC nebulizer novel patients pharmacological Potential pulmonary disease pulmonary diseases Quality of life reducing mortality respiratory Respiratory disease review Secretome selected state syndrome therapeutic potential therapy treat [DOI] 10.3390/ijms21176435 PMC 바로가기 [Article Type] Review
Coronavirus disease 2019: A tissue engineering and regenerative medicine perspectiveConcise Review Published on 2020-08-212022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory distress syndrome antiviral agent Antiviral agents ARDS biomaterial caused cell processing clinical trial clinical trials conducted Coronavirus infections COVID‐19 current death derivative described disease Disease progression driving Effect effective Efficacy evaluate Exosomes Impact infective Inflammation Last majority medical need mesenchymal stem cell MSC MSC therapy MSCs novel coronavirus disease pandemic Perspective platform progression regenerative required Research Safe stem cell syndrome the disease Therapeutic benefit Therapies therapy tissue Treatment Vaccine [DOI] 10.1002/sctm.20-0197 PMC 바로가기 [Article Type] Concise Review
Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells인간 탯줄 중간엽 줄기세포로 중증 코로나19 치료Research Published on 2020-08-182022-08-13 Journal: Stem Cell Research & Therapy [Category] MERS, 임상, [키워드] 28-day mortality C-reactive protein cell infusion change Chinese clinical Clinical characteristics Clinical improvement clinical symptom Clinical symptoms control group Coronavirus disease-19 (COVID-19) Coronavirus pneumonia COVID-19 Critical critical condition Critical illness CRP determine died effective faster fatigue hematologic Human umbilical cord mesenchymal stem cells IL-6 IL-6 level IL-6 levels incidence infusion interleukin interleukin 6 invasive invasive ventilation Lung inflammation lymphocyte Lymphocyte count measurement mesenchymal stem cell mortality rate MSCs normal range objective oxygen oxygen saturation Patient progression randomly divided reached respiratory Respiratory disease Safe severe COVID-19 Shortness of breath significant difference significantly significantly lower significantly shorter standard treatment stem cell Symptom Therapeutics Treatment treatment group two groups umbilical Umbilical cord weakness [DOI] 10.1186/s13287-020-01875-5 PMC 바로가기 [Article Type] Research
Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells A case report4900 Published on 2020-07-312022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus Antibiotics blood pressure body temperature Case report Cell Chest clinical Clinical outcome Corticosteroid COVID-19 COVID-19 case COVID-19 patient Critically ill Critically ill patient critically ill patients develop diagnosed Diagnosis effective fatigued Fever ICU immune response indicated Inflammation injection Laboratory mesenchymal stem cell modulate Mortality Patient patients patients died Pneumonia real-time RT-PCR test reported SARS-CoV-2 severe inflammation shown Side effect SPO sputum stem cell Symptom the patient therapeutic strategy throat swab tissue Tolerance transfer transferred treated Treatment umbilical were given [DOI] 10.1097/MD.0000000000021429 PMC 바로가기 [Article Type] 4900
Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) casesReview Published on 2020-06-222022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Affect anti-inflammatory macrophages ARDS B cells clinical study clinical trial coronavirus coronavirus disease country COVID-19 Cytokine storm dendritic cells Effect Exosome Exosomes health condition healthcare Immune cell induce initiated mechanism mesenchymal stem cell Mesenchymal stem cells MSC MSCs multiple organ failure Novel coronavirus novel coronavirus disease Registered Regulatory resolved SARS-CoV-2 SARS-COV-2 infection Severe case Spread stem cell syndrome T cells therapy Treatment Trial trials virus worldwide pandemic [DOI] 10.1186/s41232-020-00121-y PMC 바로가기 [Article Type] Review
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infectionArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Activation adaptive affecting Autoimmune Autoimmunity being binding Cell cell membrane Characteristics clinical setting clinical study component COVID-19 Critical Cytokine storm Cytokines cytosolic disorder effective EVs exceptional Exosome Exosomes Extensive Extracellular extracellular vesicle Extracellular vesicles Factor function Growth factors immune immune cells Immunological disorders immunomodulator Inflammation inflammatory disease Inflammatory response inhibiting Intercellular communication investigated lower risk Lung pathology membrane mesenchymal stem cell Mesenchymal stem cells Microvesicles Migration miRNA Mortality mRNA MSC MSCs outcome pandemic paracrine parent cells pathway proliferation regenerative regulate rejection Research SARS-CoV-2 SARS-COV-2 infection secreted secretion target cell tested therapeutic agent Therapies therapy tolerogenic immune response transcription factors Treatment triggered unique variety [DOI] 10.3906/biy-2002-79 PMC 바로가기 [Article Type] Article