An anti-SARS-CoV-2 metabolite is reduced in diabetes News & Views Published on 2022-05-092022-10-05 Journal: Nature metabolism [Category] COVID19(2023년), SARS, 바이오마커, [키워드] anti-SARS-CoV-2 diabete metabolite reduced [DOI] 10.1038/s42255-022-00569-x [Article Type] News & Views
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 Research Published on 2022-05-092022-10-05 Journal: Nature metabolism [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accompanied antiviral activity bind Blood cause cellular entry Comorbidity contribute COVID-19 COVID-19 pathogenesis diabete Diabetes Mellitus Diabetic diabetic patient disease severity effective healthy individual identify inhibit mechanism membrane fusion metabolite mice Mortality much higher patients patients with diabete patients with diabetes reduce respiratory tissue S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serum severe COVID-19 severity significantly lower Spike protein susceptibility the SARS-CoV-2 undergo viral infection Viral load wild-type [DOI] 10.1038/s42255-022-00567-z [Article Type] Research
Pseudanabaena galeata CCNP1313-Biological Activity and Peptides ProductionPseudanabaena galeata CCNP1313-생물학적 활성 및 펩티드 생산Article Published on 2022-05-062022-09-11 Journal: Toxins [Category] COVID19(2023년), SARS, 치료기술, [키워드] A549 activity African green monkey Analysis anticancer anticancer activity Antiviral antiviral activities antiviral activity Apoptosis Baltic Sea Breast cancer cancer cell line cancer cell lines cell line complex component Compound cyanobacteria cytotoxicity ecosystem Effect enzyme fibroblasts fraction Fractions green monkey HCoV HCoV-OC43 HCT-8 induction of apoptosis inhibitors kidney less MCF-7 metabolite metabolites new peptides. peptides potent produced Production Pseudanabaena galeata SARS-CoV-2 strain Structure tested TMPRSS2 toxins virus were used [DOI] 10.3390/toxins14050330 PMC 바로가기 [Article Type] Article
Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response염증성 장 질환 및 COVID-19 중증도와 장내 미생물총의 연관성: 변경된 면역 반응의 가능한 결과Review Published on 2022-05-052022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] alteration Altered Antiviral antiviral immune response ARDS Bacteroidaceae bowel Brain Cell chemokine chemokines circulation clearance COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines disease Disease progression dominant drastic Dysbiosis dysfunction Enterococcus event events excessive secretion Fecal sample fecal samples Gut gut microbiome gut microbiota gut-lung axis Health help homeostasis hospitalized patients hyper inflammation immune immune cells immune dysfunction immunological impair Inflammatory bowel disease invading pathogen invading pathogens involved kidney Lungs metabolite metabolites Microbiome microorganism microorganisms modulated mucosal organ Pathogens physiological poor prognosis Presence replaced respiratory tract respiratory viral infection response SARS-CoV-2 severity Signaling Staphylococcus stimulate Streptococcus the cytokine storm viral infection Viral RNA virus [DOI] 10.1007/s00284-022-02877-7 PMC 바로가기 [Article Type] Review
Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19우한의 여러 단계에 있는 환자의 혈청 대사체학 특성 분석으로 COVID-19의 중요한 바이오마커 식별Article Published on 2022-05-022022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alpha-methylstyrene Biomarker Biomarkers caused characterization chavicol clinical disease clinical measurement clinical measurements comprehensive analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical death degranulation differentially expressed example feature identification immune responses information Intervention involved knowledge lead metabolism metabolite metabolites metabolomic metabolomic analysis metabolomics Pathogenesis pathway Patient patients performed phosphate physiological Platelet potential therapeutic agent potential therapeutic agents predicted propylparaben rehabilitation patient respiratory SARS-CoV-2 sera serum severe acute respiratory syndrome Coronavirus Spread Stage stages therapeutic agents therapeutic target therapeutic targets triethanolamine uninfected Wuhan [DOI] 10.3389/fcimb.2022.882661 PMC 바로가기 [Article Type] Article
Oral hymecromone decreases hyaluronan in human study participants경구 hymecromone은 인간 연구 참가자의 hyaluronan을 감소시킵니다Clinical Trial Published on 2022-05-022022-09-11 Journal: The Journal of Clinical Investigation [Category] 비임상, [키워드] 4-methylumbelliferone Accelerator Administered Adults analyzed animal models approved approved drugs Arm asked baseline breath catalyst Concentration conducted COVID-19 infection decrease dose dose-dependent manner doses drug concentration Europe exposure to Extracellular matrix fibrosis glycosaminoglycan greater greater decrease healthy hymecromone hypertension implicated in vitro Inflammation inhibit inhibitor Medicine metabolite NIH Open-label oral other diseases Pathogenesis pathophysiology pulmonary disease pulmonary diseases pulmonary fibrosis pulmonary hypertension reduction in serum significant decrease single-center sputum Stanford study participant subject therapy Tolerability Treatment [DOI] 10.1172/JCI157983 PMC 바로가기 [Article Type] Clinical Trial
Molnupiravir; molecular and functional descriptors of mitochondrial safety몰누피라비르; 미토콘드리아 안전성의 분자 및 기능 설명자Article Published on 2022-05-012022-09-11 Journal: Toxicology and applied pharmacology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] active form Adult patients Analyzer antiviral drug antiviral drugs approved arrest cell line Concentration concentrations copy number COVID-19 Culture cytotoxicity DNA polymerase dose drug emergency treatment Endpoint expression flux functional Genome HepG2 HepG2 cell incorporation inhibit lack mechanism metabolite Mitochondria mitochondrial mitochondrial DNA Mitochondrial function mitochondrial gene molecular molnupiravir Mutation N-hydroxycytidine NHC nucleoside Patient phenotypic PolG POLRMT progression RdRP replicating virus Replication resulting risk RNA polymerase significantly specificity the SARS-CoV-2 Toxicity Transcription Treatment triphosphate U.S. FDA viral genome virus was measured [DOI] 10.1016/j.taap.2022.116003 PMC 바로가기 [Article Type] Article
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool Research Published on 2022-04-202022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] addition adipose Amino acid amino acid metabolism Analysis applied baseline benefit bile acid change changes clinical parameter Concentration control group correlated Critical derivative dietary change disease Effect Endpoint Exercise intervention Fatty liver Glucose highlight Human identify Intervention intervention group Lipid Liver disease maximum oxygen consumption mechanism metabolic pathway metabolite metabolomics NAFLD participant participated Patient performed plasma profile provided Randomized significantly Stool subject tissue Urine Waist circumference was used weight loss [DOI] 10.1038/s41598-022-10481-9 [Article Type] Research
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects Research Published on 2022-03-162022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered adverse events AUC blood sample calculated Chinese collected dose drug candidate enrolled evaluate exhibited food-effect had no healthy subject healthy subjects indicated JT001 MAD metabolite occurred patients with COVID-19 per protocol pharmacokinetic analysis Phase I PK parameters Placebo plasma repeated Safety SARS-CoV-2 Serious Adverse Event subject Support Tablet Tolerability VV116 [DOI] 10.1038/s41401-022-00895-6 [Article Type] Research
Environmental and human health risk assessment of mixture of Covid-19 treating pharmaceutical drugs in environmental waters환경 및 인간 건강 위험 환경 해역에서 의약품 치료 약물의 혼합물의 환경 및 인간 건강 위험 평가Article Published on 2022-03-152022-08-31 Journal: The Science of the total environment [Category] MERS, SARS, 신약개발, 치료제, [키워드] acceptable daily intake Algae Analysis Aquatic organisms calculated Chronic toxicity Compound compounds Concentration Consumption COVID-19 COVID-19 pandemic daphnia database drug drugs ecological Ecological risk Effects fish followed by food Health Human Human health effects. Lopinavir Maximum allowable concentration metabolite metabolites mixture organism predicted Quotient responsible ribavirin risk Ritonavir Surface water Toxicity Vulnerable species water waters [DOI] 10.1016/j.scitotenv.2021.152485 PMC 바로가기 [Article Type] Article