Efficacy and safety of tofacitinib modified-release 11 mg once daily plus methotrexate in adult patients with rheumatoid arthritis: 24-week open-label phase results from a phase 3b/4 methotrexate withdrawal non-inferiority study (ORAL Shift)Original research Published on 2021-06-082024-09-04 Journal: RMD open [Category] 대상포진, [키워드] Arthritis methotrexate Patient reported outcome measures Rheumatoid [DOI] 10.1136/rmdopen-2021-001673 PMC 바로가기 [Article Type] Original research
Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic ImplicationsReview Published on 2021-06-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Administered Angiotensin-converting enzyme anti-cytokine anti-infective drug Anti-inflammatory association Atherosclerosis blockers cardiovascular cardiovascular disease Colchicine coronavirus cytomegalovirus determine disease drug drugs early diagnosis Evidence Factor heart muscle Helicobacter pylori herpes simplex virus Human immunodeficiency virus implication increased risk Infection Infection prevention infections Inflammation management methotrexate Mortality novel outcomes P2Y12 pathogen Patient persist Pneumonia progression proinflammatory receptor receptor inhibitors reduction residual risk risk factor Risk factors therapeutic therapy Treatment triggering vasculature viral infection [DOI] 10.3390/jcm10122539 PMC 바로가기 [Article Type] Review
Tumor necrosis factor inhibitors are associated with a decreased risk of COVID ‐19‐associated hospitalization in patients with psoriasis—A population‐based cohort studyOriginal Article Published on 2021-06-052022-10-31 Journal: Dermatologic therapy [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted Admission analyses cohort study comparable Complication conducted coronavirus disease COVID COVID‐19 COVID‐19 infection Cox regression exposure to groups Hospitalization incidence rate infection‐ bacterial/fungal/viral inhibitor investigated methotrexate Mortality Necrosis outcome outcomes pandemic Patient patients treated psoriasis risk significant difference treated Treatment tumor necrosis factor [DOI] 10.1111/dth.15003 PMC 바로가기 [Article Type] Original Article
Biomedical Text Link Prediction for Drug Discovery: A Case Study with COVID-19Article Published on 2021-05-262022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome Algorithm Anti-inflammatory antiviral therapy Artemisinin Biotin Bone marrow calculated Chloroquine complement complex Complex networks coronavirus Coronaviruses COVID-19 data sets Diseases drug drug candidate Drug discovery Efficacy envelope proteins heterogeneous identify include inhibitors interferon knowledge leukocyte literature review machine learning MERS methotrexate natural language processing nucleoside analogs occur outbreak predict predicted prediction protease inhibitors Proteins Repurposed drug Repurposed drugs SARS Coronavirus SARS-CoV-2 SARS-CoV-2 treatment Side effects Suramin syndrome text text mining Therapies treat vaccination with COVID-19 [DOI] 10.3390/pharmaceutics13060794 PMC 바로가기 [Article Type] Article
Impact of Inflammatory Immune Dysfunction in Psoriasis Patients at Risk for COVID-19Article Published on 2021-05-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-viral response Antiviral Asymptomatic collected Comorbidities Comorbidity Complication concomitance COVID-19 COVID-19 symptom cytokine level Cytokines cytometric deviation drug exhibited group healthy control healthy controls Hospitalization IgG IL-17A IL-18 IL-1β IL-27 IL-6 immune immune response Immune-mediated immunological mechanism Impact involved lack methotrexate outcome Patient preventive measures pro-inflammatory cytokine proinflammatory psoriasis risk SARS-CoV-2 Seropositivity susceptibility Therapeutic approach therapy TNF viral infection viral infections [DOI] 10.3390/vaccines9050478 PMC 바로가기 [Article Type] Article
Effect of janus kinase inhibitors and methotrexate combination on malignancy in patients with rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trialsReview Published on 2021-04-282024-09-02 Journal: Autoimmunity Highlights [Category] 대상포진, [키워드] Baricitinib Decernotinib filgotinib jak inhibitors methotrexate Peficitinib rheumatoid arthritis Tofacitinib Upadacitinib [DOI] 10.1186/s13317-021-00153-5 PMC 바로가기 [Article Type] Review
Increase rate of ruptured tubal ectopic pregnancy during the COVID-19 pandemicCOVID-19 전염병 동안 파열된 난관 자궁외 임신의 비율 증가Article Published on 2021-04-012022-09-11 Journal: European journal of obstetrics, gynecology, and re [Category] Coronavirus, SARS, 바이오마커, [키워드] 2020 COVID-19 pandemic abdomen advanced disease age Behavior Blood Complication conception control group correlated COVID COVID 19 COVID-19 pandemic decrease Diagnosis ectopic Ectopic pregnancy emergency room evaluate Evidence fluid volume gestational age gravity Health Health care increase increase in last menstrual period lockdown Maternal maternal age menstrual methotrexate mode no difference non-infected p value pandemic parity Pregnancy pregnant presenting reproduction retrospective cohort study rupture statistically significant study group the mean the study group treated Treatment two groups Volume women [DOI] 10.1016/j.ejogrb.2021.01.054 PMC 바로가기 [Article Type] Article
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replicationSARS-CoV-2는 바이러스 복제를 위해 엽산과 단일 탄소 대사를 납치합니다.Article Published on 2021-03-152022-09-10 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome coronavirus Alter Analysis bypassing carbon carbon metabolism cell growth cellular metabolism coronavirus coronavirus 2 COVID-19 pandemic de novo Effect folate Glucose growth Host host cell infected cells inhibitor inhibitors Intracellular lifecycle metabolism metabolomic metabolomics methotrexate novel beta-coronavirus Outbreaks performed post-transcriptional level purine Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support survival targeted therapy transcriptional translation Viral viral genome viral replication Viral RNA virus Virus-host interactions viruses [DOI] 10.1038/s41467-021-21903-z PMC 바로가기 [Article Type] Article
Vitamin D and COVID‐19 in an immunocompromised patient with multiple comorbidities—A Case ReportCase Reports Published on 2021-03-052024-09-04 Journal: Clinical Case Reports [Category] 대상포진, [키워드] COVID‐19 methotrexate Risk factors SARS‐CoV‐2 severity Vitamin D3 [DOI] 10.1002/ccr3.4010 PMC 바로가기 [Article Type] Case Reports
Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme류마티스 관절염에서 우파다시티닙의 안전성 프로필: SELECT 3상 임상 프로그램의 통합 분석Clinical Trial Published on 2021-03-012023-06-01 Journal: Annals of the rheumatic diseases [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] adalimumab Arthritis methotrexate Rheumatoid [DOI] 10.1136/annrheumdis-2020-218510 PMC 바로가기 [Article Type] Clinical Trial