Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents
Short communication
[키워드] acute lung injury
acute respiratory distress syndrome
addition
anti-cytokine storm
ARDSacute respiratory distress syndrome
BALFbronchoalveolar lavage fluid
Bronchoalveolar lavage fluid
candidate
caused
CCL-5chemokine (C-C motif) ligand 5
chemokine (C-C motif) ligand 5
Coronavirus disease 2019
COVID-19
COVID-19coronavirus disease 2019
CSS
CSScytokine storm syndrome
CXC chemokine ligand 1
CXCL1CXC chemokine ligand 1
Cytokine storm syndrome
drug
drug library
Drug repurposing
effective
entecavir
FDAU.S. Food and Drug Administration
G-CSFgranulocyte-colony stimulating factor
granulocyte-colony stimulating factor
half-maximal inhibitory concentration
high mortality
hPBMChuman peripheral blood mononuclear cell
human peripheral blood mononuclear cell
IC50half-maximal inhibitory concentration
IL-10
ILInterleukin
Inflammatory cytokine
inhibited
interferon-γ-inducible protein 10
interleukin
Intervention
IP10interferon-γ-inducible protein 10
lipopolysaccharide
LPSlipopolysaccharide
Macrophage
macrophage inflammatory protein 1 alpha
MCP-1monocyte chemoattractant protein -1
MERSMiddle East Respiratory Syndrome
mice
Middle East respiratory syndrome
MIP-1αmacrophage inflammatory protein 1 alpha
mitigate
monocyte chemoattractant protein -1
mononuclear cell
NF-κB
NLR family PYRIN domain containing-3
NLRP3NLR family PYRIN domain containing-3
patients
Peripheral blood
reduce
respiratory
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2Severe Acute Respiratory Syndrome Coronavirus -2
Severe Acute Respiratory Syndrome Coronavirus -2
Spread
suppressed
survival
syndrome
TNF-α
Treatment
U.S. Food and Drug Administration
[DOI] 10.1016/j.biopha.2020.110643 [Article Type] Short communication
[DOI] 10.1016/j.biopha.2020.110643 [Article Type] Short communication