Dysregulation of the leukocyte signaling landscape during acute COVID-19급성 COVID-19 동안 백혈구 신호 전달 환경의 조절 장애Article Published on 2022-04-142022-09-12 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute COVID-19 approach Cell cellular activation circulating claimed correlated COVID-19 COVID-19 pandemic Cytometry driving dysregulated functional IFN-γ IL-6 level immune dysfunction immune effector cell immune function immune system immunology Immunosuppression Inflammation leukocyte lung lymphoid marker mechanism molecular mechanism monocyte myeloid cell pathogenesis of COVID-19 pathophysiologic phosphoproteome Phosphorylation populations Signaling signaling pathway STAT3 suppressed systemic inflammatory response T cell T cells These data tissue injury [DOI] 10.1371/journal.pone.0264979 PMC 바로가기 [Article Type] Article
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19Research article Published on 2022-04-142022-10-05 Journal: Blood advances [Category] SARS, 바이오마커, 비임상, [키워드] activated Activation aggregate amplification amplify amplifying Analysis approach assays binding CD16 Coagulation Combination COVID-19 Critically ill patient driving Evidence Ex vivo exhibited expression fibrinogen function functional high risk highlight HLA-DR hypercoagulability hyperinflammation identify in vitro indicated Inflammation Inflammatory Inflammatory cytokine Inflammatory mediators inflammatory monocyte Interaction interleukin-1β life-threatening mechanism mechanisms monocyte P-selectin pathogenesis of COVID-19 Patient pharmacological Platelet platelet activation Platelets presenting proinflammatory cytokines receptor response RNA-sequencing SARS-COV-2 infection secretion severe COVID-19 Signaling single-cell subset thromboembolic complications Thromboinflammation tissue tumor necrosis factor-α with COVID-19 [DOI] 10.1182/bloodadvances.2021006680 [Article Type] Research article
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Research Published on 2022-04-062022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 치료기술, 치료법, 치료제, [키워드] abort activate activated Activation acute respiratory distress AIM2 Autopsy blood monocyte caspase-1 cause Cell contribute COVID-19 pathogenesis Culture death endothelial cells epithelial gasdermin D infected cell infected with SARS-CoV-2 Infection Infectious virus Inflammasome inflammasomes Inflammation Inflammatory Inflammatory cell death invasive lung Macrophage monocyte Monocytes NLRP3 patients with COVID-19 plasma promote pyroptosis receptors recipient replicate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 supernatant systemic inflammation tissue-resident macrophages Trigger undergo Vaccine virus [DOI] 10.1038/s41586-022-04702-4 [Article Type] Research
Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme다형성 교모세포종에서 코로나바이러스 수용체의 포괄적인 발암성 특징Article Published on 2022-04-062022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 Analysis ANPEP approaches association bioinformatics Brain brain tissue Cancer caused clinical development Comprehensive coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic Cox regression analysis demonstrated DPP4 ENPEP expression functional GBM health system immune infiltration incidence individuals Kaplan-Meier survival curve molecular monocyte mRNA oncogenic Patient performed poor prognosis positively correlated potential therapeutic target protein level protein-protein interaction receptor receptors SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly increased survival TMPRSS2 [DOI] 10.3389/fimmu.2022.840785 PMC 바로가기 [Article Type] Article
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS표적화 가능한 '불량' 호중구 하위 집합인 [CD11b+DEspR+] 면역형은 급성 호흡 곤란 증후군(ARDS) 및 COVID-19-ARDS의 중증도 및 사망률과 관련이 있습니다Article Published on 2022-04-042022-09-11 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antibody Apoptosis ARDS arise assays association blocked Critical death detect dual dysregulated Endothelin Ex vivo expressing humanized identify IgG4 immunotype induce induction of apoptosis inhibitor inhibitors insufficiency internalization kill Ligand lung tissue MOF monocyte Monocytes Mortality NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps neutrophil function Neutrophils pathogenic Pathogens Patient peptide pleiotropic progression receptor respiratory distress Respiratory distress syndrome rhesus scRNA-seq severity syndrome Therapeutic approach tissue injury [DOI] 10.1038/s41598-022-09343-1 PMC 바로가기 [Article Type] Article
Role of Tocilizumab in Down Regulating sCD163 Plasmatic Levels in a Cohort of COVID-19 PatientsCOVID-19 환자 집단에서 sCD163 혈장 수준을 하향 조절하는 토실리주맙의 역할Article Published on 2022-04-042022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] anti-IL-6 receptor Biomarker both group CD163 Cell Clinical outcome clinical utility Cohort comparable control group COVID-19 COVID-19 patient COVID-19 patients defined died discharge down-regulated early stage ELISA enrolled evaluated expressed Follow-up group groups healthy donor Hospital admission Hospitalization IL-6 Inflammatory involved Laboratory parameters lethality rate Level Lineage macrophages mechanical ventilation monoclonal antibody monocyte monocytes/macrophages outcome plasma Pneumonia pro-inflammatory proteolytic cleavage receptor reduce reduction in reductions in Regulating Regulation required role SARS-CoV-2 sCD163 severity of COVID-19 statistically stratified TCZ the disease Tocilizumab Treatment [DOI] 10.3389/fimmu.2022.871592 PMC 바로가기 [Article Type] Article
The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19항-C5a 항체 빌로벨리맙은 중증 COVID-19 환자에서 C5a를 효율적으로 억제합니다Article Published on 2022-04-012022-09-11 Journal: Clinical and translational science [Category] 임상, 진단, [키워드] 1:1 Activation adaptive Analysis anaphylatoxin C5a antibody assigned benefit best Blood C3a C5a cause Chain Reaction Coagulation Coagulation system Concentration control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia demonstrated drug concentration enzyme favor geometric geometric mean IFX-1 Infection infection site inhibit IQR leads median monoclonal antibody monocyte Monocytes neutrophil Neutrophils oxidative Patient plasma polymerase chain polymerase chain reaction Randomly ranged real-time polymerase chain reaction receive releases reported Result Safe Sample secondary outcome severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia supportive care suppressed suppression tissue damage Trial vilobelimab [DOI] 10.1111/cts.13213 PMC 바로가기 [Article Type] Article
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article