Performance of anterior nares and tongue swabs for nucleic acid, Nucleocapsid, and Spike antigen testing for detecting SARS-CoV-2 against nasopharyngeal PCR and viral culture비인두 PCR 및 바이러스 배양에 대한 SARS-CoV-2 검출을 위한 핵산, 뉴클레오캡시드 및 스파이크 항원에 대한 전방 비강 및 혀 면봉 검사의 성능Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 95% CI alternative method Antigen antigen detection Chain Reaction collected conducted COVID-19 COVID-19 testing diagnostic Diagnostic performance diagnostic sensitivity effective evaluated highest in some nare nasal nasopharyngeal nasopharyngeal swabs nucleic acid nucleocapsid PCR PCR tests performance polyester polymerase chain reaction reference standard relative reverse transcriptase RT-PCR RT-PCR test RT-PCR testing RT-PCR tests SARS-CoV-2 SARS-CoV-2 testing sensitivity specificity specimen specimen collection spike Swab swab specimen symptomatic adults tongue transcriptase viral culture with COVID-19 [DOI] 10.1016/j.ijid.2022.02.009 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of SARS-CoV-2 variants in nasopharyngeal swabs and wastewaters비인두 면봉 및 폐수에서 SARS-CoV-2 변이체의 신속하고 민감한 검출Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Affect allelic appearance carried characterized clade clades containment strategies detect diffusion disease severity Effectiveness Evolution functional genomic genotypes Genotyping assay help host immunity house Interaction limit mutations Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 NGS poor quality Rapid SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spread tested urgency variant Variation variations viral genome virus Virus evolution VOCs wastewater whole-genome sequencing [DOI] 10.1016/j.diagmicrobio.2021.115632 PMC 바로가기 [Article Type] Article
COVID-19 in Elderly, Immunocompromised or Diabetic Patients-From Immune Monitoring to Clinical Management in the Hospital고령자, 면역저하, 당뇨병 환자의 코로나19-면역 모니터링부터 병원 내 임상 관리까지Article Published on 2022-04-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cellular Cellular immune response cellular immune responses clinical Clinical management Cohort cohorts Comorbidities complicate Complication coronavirus correlated Course COVID-19 Ct value cycle threshold detectable develop diabete diabetes Diabetes Mellitus Diabetic diabetic patient elderly elderly patients Factor group Healthcare system hospital Hospitalization Hospitalized humoral Humoral and cellular immune responses humoral immune response humoral immune responses immune response immune responses Immunocompromised Immunocompromised patient Immunocompromised patients increased risk Isolation majority monitoring MOST Nasopharyngeal swab nasopharyngeal swabs Nosocomial infections novel nursing homes pandemic Patient patient cohort patient groups patients patients with diabete positive producing reduced replication-competent virus representing Respiratory illness respond robust SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity severe acute respiratory syndrome Coronavirus symptomatic symptomatic COVID-19 triggered viral culture viral loads virus [DOI] 10.3390/v14040746 PMC 바로가기 [Article Type] Article
SARS-CoV2 RT-PCR assays: In vitro comparison of 4 WHO approved protocols on clinical specimens and its implications for real laboratory practice through variant emergenceSARS-CoV2 RT-PCR 분석: 임상 표본에 대한 4가지 WHO 승인 프로토콜의 시험관 내 비교 및 변이체 출현을 통한 실제 실험실 실습에 대한 의미Article Published on 2022-03-282022-09-11 Journal: Virology Journal [Category] SARS, 변종, [키워드] Analysis analyzed approved Berlin protocol CDC Charité China choice COVID-19 demonstrated described Diagnosis evaluate false False negative False positive Genome Hong Kong implication in vitro Internal control Interpretation IPP Laboratory Multiplexing Mutation nasopharyngeal sample Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal swabs New Nsp12 Nsp9 Open reading frame ORF1ab Paris PCR testing positive protocol provided Randomly RdRP recommendation RNA-dependent RNA polymerase RT-PCR RT-PCR testing SARS-CoV2 SARS-CoV2 genome selected sensitivity specimen specimens target targets tested Tunis variant Viral load WHO worsened [DOI] 10.1186/s12985-022-01784-4 PMC 바로가기 [Article Type] Article
Multiplex, Real-Time, Point-of-care RT-LAMP for SARS-CoV-2 Detection Using the HFman ProbeHFman 프로브를 사용한 SARS-CoV-2 검출을 위한 다중, 실시간, 현장 진료 RT-LAMPArticle Published on 2022-03-252022-09-11 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] addition affecting Alpha alpha and delta variants amplification arising binding Chain Reaction clinical sample COVID-19/SARS-CoV-2 Delta variants detection diagnostic diagnostic test DNA DNA polymerase Efficiency evade Evolution extracted RNA gold gold standard HFman probe high-fidelity DNA polymerase Impact isothermal LAMP limitation mechanism multiplex multiplex LAMP nasopharyngeal sample Nasopharyngeal samples nasopharyngeal swabs non-specific non-specific amplification nucleic acid overcome performed POCT point-of-care point-of-care testing (POCT). polymerase chain polymerase chain reaction positive primer probe Quantitative reaction Result reverse transcription RT-LAMP SARS-CoV-2 SARS-CoV-2 viral selective sensitivity sequence sequences specificity Spread subject Tolerance variant variants viral evolution [DOI] 10.1021/acssensors.1c02079 PMC 바로가기 [Article Type] Article
Effects of Casirivimab/Imdevimab Monoclonal Antibody Treatment among Vaccinated Patients Infected by SARS-CoV-2 Delta VariantSARS-CoV-2 Delta 변이에 감염된 백신 접종 환자에서 Casirivimab/Imdevimab 단일클론항체 치료 효과Article Published on 2022-03-212022-09-11 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis B.1.617.2 Casirivimab casirivimab/imdevimab Chest Chest computed tomography clinical clinical evolution clinical manifestations Clinical presentations cocktail Computed tomography coronavirus coronavirus 2 Delta delta variant Disease progression early stage early stages Effect effective Efficacy evaluated Evolution FIVE Hospitalized Imdevimab Infection mAb mAbs monoclonal antibodies monoclonal antibody monoclonal antibody treatment Nasopharyngeal swab nasopharyngeal swabs Next-generation sequencing NGS outcomes Patient patients performed prevent disease progression real-time RT-PCR Regression respiratory Respiratory failure Safe SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 submitted Symptom Symptoms thymoma Treatment Vaccine variant variants variants of concern Viral viral load reduction [DOI] 10.3390/v14030650 PMC 바로가기 [Article Type] Article
Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab중화 단일클론항체 밤라니비맙 치료 후 코로나19로 입원한 환자의 비인두 면봉 유전자 발현 패턴과 혈청 바이오마커 간의 관계Randomized Controlled Trial Published on 2022-03-182022-09-11 Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence Analysis Analytes antibody formation Antibody Response approach bamlanivimab Biomarker biomarker signature Biomarkers Blood change changes in circulation clinical clinical trial Cohort collected connection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL10 CXCL11 detect disease Elecsys Gene Expression gene expression pattern groups healthy control healthy controls Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IFNγ IgA IgG titer IgG titers IgM IL-6 immune response immunoassay immunological implementation Infection Inflammatory inflammatory protein Inflammatory response interferon response Level Luminex MCP-3 MONITOR monoclonal antibody nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs Neutralizing not affect not significantly different observation observations Patient patient population patients patients hospitalized patients with COVID-19 peaked Peripheral blood Placebo presence or absence profile Protein Randomized receive reductions reductions in relationship remained repeated measure respiratory RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seroconversion serology serum serum biomarker Serum protein serum proteins serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarities single dose systemic disease therapeutic Treatment Treatment strategies utility viral-induced was performed was used were used while with COVID-19 [DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry Analysis for the Direct Detection of SARS-CoV-2 in Nasopharyngeal Swabs비인두 면봉에서 SARS-CoV-2의 직접 검출을 위한 매트릭스 보조 레이저 탈착 및 이온화 비행 시간 질량 분석 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anion exchange resin biological molecule biological molecules cartridge Chain Reaction Combination complex contagious coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients detect detection Diagnostic method digested Direct Evidence flight identify in some inoculated ionization labor-intensive Laser limit of detection mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens nasopharyngeal swabs nucleocapsid patients PCR peptide peptides polymerase chain polymerase chain reaction positive result purification purified Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARS-CoV-2-specific peptide SARS-CoV-2-specific peptides selected separated Seven severe acute respiratory syndrome Coronavirus specimen specimens Spectrometry Swab the SARS-CoV-2 trypsin Viral load was performed [DOI] 10.1021/acs.analchem.1c04328 PMC 바로가기 [Article Type] Article
Direct comparison of Xpert Xpress, FilmArray Respiratory Panel, Lumipulse antigen test, and RT-qPCR in 165 nasopharyngeal swabs165 Nasopharyngeal Swabs에서 Xpert Xpress, FilmArray 호흡기 패널, Lumipulse 항원 검사 및 RT-QPCR의 직접 비교Research Article Published on 2022-03-042022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] 95% CI 95% confidence interval Antigen approved automated COVID-19 Ct values diagnostic test diagnostic tests Direct except for exhibited FilmArray high correlation less Lumipulse NAAT Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acid amplification nucleic acid amplification test offer Panel positive Quantitative random random access respiratory Result RT-qPCR RT-qPCR assays SARS-CoV-2 sensitivity specificity Viral Viral load viral loads Xpert Xpress [DOI] 10.1186/s12879-022-07185-w PMC 바로가기 [Article Type] Research Article
Performance evaluation of Elecsys SARS-CoV-2 Antigen immunoassay for diagnostic of COVID-19코로나19 진단을 위한 Elecsys SARS-CoV-2 항원 면역분석의 성능 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aims alternative Antigen antigen detection antigen tests Chain Reaction complement coronavirus COVID-19 cross Cross reactivity cross-reactivity Cycle threshold value diagnostic Elecsy Elecsys evaluate HKU1 identify immunoassay individual Infection Influenza Influenza virus Nasopharyngeal swab nasopharyngeal swabs Negative predictive value NPV OC43 other respiratory virus Other respiratory viruses parainfluenza virus performance point of care polymerase chain reaction positive PPV Predictive value Randomly ranged reduce reference test respiratory viruses reverse transcription Reverse transcription-polymerase chain reaction rhinovirus Roche Diagnostics RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigen tests SARS-CoV-2 transmission selected sensitivity severe acute respiratory syndrome Coronavirus specificity STAT Symptoms [DOI] 10.1002/jmv.27412 PMC 바로가기 [Article Type] Article