Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] AD-high-risk scores Alzheimer’s disease Astrocyte Cell cell population cognitive Cognitive impairment COVID-19 COVID-19 patients demonstrated disease disease-associated dysfunction GWAS identify mechanism Neuroinflammation Neuron neuronal pathway proteomic reported reveal RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection single-nucleus RNA sequencing. subtype synaptic syndrome target therapeutic intervention transcriptomic [DOI] 10.3389/fimmu.2022.967356 PMC 바로가기
Neuroinflammation in Dementia-Therapeutic Directions in a COVID-19 Pandemic SettingArticle Published on 2022-09-222022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] activate Activation Affect cognitive complications Concentration COVID-19 cytokine production Dementia direction dysfunction Efficacy Factors Glia glial cell glial cells group of diseases heterogenous highlight human organism IL-1β immune response Inconclusive Inflammation Inflammatory Intervention molecular neurodegenerative Neuroinflammation Neuron NSAID outcome pathology peripheral pro-inflammatory signaling provide resulting risk SARS-CoV-2 setting shown Side effects therapeutic approaches TNF TNF antagonist TNF antagonists while [DOI] 10.3390/cells11192959 PMC 바로가기
The COVID-19 pandemic and Alzheimer’s disease: mutual risks and mechanismsArticle Published on 2022-09-112022-11-16 Journal: Translational Neurodegeneration [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor acute respiratory syndrome age Alzheimer’s disease angiotensin-converting enzyme 2 ApoE approach association caused cell membranes Central nervous system clinical outcomes CNS coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic disease Diseases dysfunction expressed Genotype host cell increasingly individual key factor life-threatening mechanism Neuroinflammation neurological predominant recent receptor risk risk factor SARS-CoV-2 SARS-COV-2 infection susceptible the spike protein those with comorbidities [DOI] 10.1186/s40035-022-00316-y PMC 바로가기
The choroid plexus and its role in the pathogenesis of neurological infectionsArticle Published on 2022-09-102022-11-15 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] Activation Alter bidirectional Blood–CSF barrier Borrelia Borrelia burgdorferi Brain Cell cells cellular response Central nervous system cerebrospinal fluid changes in chemotaxis choroid Choroid plexus circulating CNS CNS disorder cytokine dendritic cells develop Diseases disorder driving epithelia epithelial epithelial cell function greater highlight homeostasis homing hydrocephalus Immune cell immune cells immune response Immunity immunological Including induce Infection infections Inflammation inflammatory signal John Cunningham virus junction knowledge less macrophages Neuroinflammation neurological pathogen Pathogenesis Pathogens pharmacological intervention promote provide Research SARS-CoV-2 shown T cells target these cell virus Zika virus [DOI] 10.1186/s12987-022-00372-6 PMC 바로가기
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice modelarticle Published on 2022-09-072024-09-02 Journal: Journal of Neuroinflammation [Category] 대상포진, [키워드] hPMSCs miR-26a-5p Neuroinflammation neuropathic pain sEVs Wnt5a [DOI] 10.1186/s12974-022-02578-9 PMC 바로가기 [Article Type] article
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘Review Published on 2022-09-012022-09-11 Journal: Neural Regen Res [Category] 비임상, [키워드] Alzheimer's disease Alzheimer’s disease animal model autophagy breath caused disease Disease progression downstream signaling pathway downstream signaling pathways drug drug re-positioning Effect effective enhancement epidermal epidermal growth factor epidermal growth factor receptor Evidence examined explained growth factor human epidermal growth factor receptor-2 kinase inhibitors mechanism modulation molecular mechanism neurodegeneration neurodegenerative Neurodegenerative diseases Neuroinflammation neurological manifestation neurological manifestations Numerous oxidative oxidative stress Perspective positioning Prospective clinical trial recent receptor receptor inhibitor Research shown signaling pathways Therapeutic approach tyrosine tyrosine kinase inhibitors [DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo HypothesisArticle Published on 2022-08-282022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] accompanied acute respiratory syndrome aggregation alpha-synuclein Brain cargo cascades caused clinical manifestation clinical manifestations complex contributing to Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 Diagnosis disease disease severity Dopaminergic neuron Evidence Exosome Exosomes Extracellular host protein Infection Inflammation Inflammatory Inflammatory mediators Intercellular communication long-lasting modulated molecular neurodegeneration neurodegenerative Neuroinflammation neurological Parkinson’s disease parkinsonian Parkinsonism Pathogenesis pathophysiological conditions pathway phenotype Pneumonia post-COVID-19 Post-infection prevalent promoter Protein reflected SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA similarity substantia Symptoms syndrome Transmission Viral proteins virus [DOI] 10.3390/ijms23179739 PMC 바로가기
Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyRandomized Controlled Trial Published on 2022-08-172022-10-05 Journal: Cells [Category] 임상, [키워드] absence affected age ameliorated Anosmia average baseline Biomarkers Brain brain fog Combination COVID COVID-19 disorders Effect group Hyposmia interval investigated Long long-haul COVID syndrome longitudinal lutein Luteolin measure mechanisms memory men Mental mental clouding Neuroinflammation Olfaction olfactory olfactory dysfunction olfactory threshold olfactory training outcomes palmitoylethanolamide parosmia Patient patients PEA-LUT Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence qualitative smell disorders Quantitative Randomized receive recruited reduction in regimen remaining group Result SARS-COV-2 infection self-report measure severity smell disorders. subjects subsequent therapy thresholds Treatment were assessed women [DOI] 10.3390/cells11162552 PMC 바로가기 [Article Type] Randomized Controlled Trial
Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complicationsReview Published on 2022-08-012023-07-09 Journal: Acta neurologica Belgica [Category] COVID19(2023년), [키워드] CCL11 COVID-19 Eotaxin-1 Neuroinflammation SARS-CoV-2 [DOI] 10.1007/s13760-022-01984-3 PMC 바로가기 [Article Type] Review