Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patientsArticle Published on 2020-06-012022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료법, [키워드] Alter antibodies antibody B-cell B-cell epitope coronavirus COVID-19 convalescent patients COVID-19 patient diagnostic diagnostics elicit fusion peptide help human antibody response identify IgG immunodominant immunogenic linear linear epitope neutralising neutralising antibody overlapping Patient peptides Receptor binding domain Region SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera serological test serology significantly spike glycoprotein Spike protein target targets the SARS-CoV-2 vaccine candidate Vaccine development Vaccines viral infection Virus neutralisation [DOI] 10.1038/s41467-020-16638-2 PMC 바로가기 [Article Type] Article
Stability and neutralising capacity of SARS-CoV-2-specific antibodies in convalescent plasma회복기 혈장 내 SARS-CoV-2 특이 항체의 안정성 및 중화능Article Published on 2020-06-012022-09-12 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 진단, [키워드] convalescent plasma neutralising SARS-CoV-2-specific antibody [DOI] 10.1016/S2666-5247(20)30037-9 PMC 바로가기 [Article Type] Article
Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cellsResearch Article Published on 2019-07-082022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Actin activate activated Analysis Antigen binding block Cell cellular change DCs dendritic cell dendritic cells disease-causing down-regulated ENhance explain functional Gene Expression Gene ontology Host IBV immune immune function inactivated indicated induce Infection Infectious Bronchitis Virus innate response Interaction leukocyte lncRNA long non-coding RNA Lymphocytes MAPK maturation mechanism Microarray microRNA miRNA miRNAs mRNA mRNAs neutralising non-coding RNA oxidative phosphorylation pathogenic mechanism pathway Pathway analysis performed presenting Protein provide recent regulate Research respond responsible Result significantly suggested supplementary material T cells target gene transcription factor transendothelial migration up-regulated viruses [DOI] 10.1186/s12864-019-5940-6 PMC 바로가기 [Article Type] Research Article
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial건강한 성인에서 HIV를 예방하기 위한 아데노 관련 바이러스 매개 면역 예방: 1상 무작위 대조 시험Article Published on 2019-03-152022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] adeno-associated virus adverse event adverse events AIDS alternative analyses anti-drug antibody antibody assigned cassettes Clinical research Cohort Complete Consent detect development dose dose-escalation double-blind eligibility eligible ELISA expression finding Follow-up foundation funding Future gene delivery Gene Expression generally mild genomes groups healthy HIV HIV antibodies HIV infection immunisation induce initiative Intervention Intramuscular injection Melinda Gate Melinda Gates men moderate muscle biopsy neutralisation neutralisation activity neutralising Neutralising Antibodies neutralising antibody Phase 1 Placebo placebo-controlled Prevent provided public health quadricep quadriceps randomised randomised controlled trial Randomly reactogenicity receive Registered Research resolved RT-PCR screened Serious Adverse Event Serious Adverse Events serotype serum sustained T-cell Response T-cell responses Tolerability Trial United State United States Vaccine virus Volunteer volunteers was done were recorded [DOI] 10.1016/S2352-3018(19)30003-7 PMC 바로가기 [Article Type] Article