Coronavirus Disease in Children: A Single-Center Study from Western Saudi ArabiaResearch Article Published on 2021-07-272022-10-29 Journal: International Journal of Pediatrics [Category] COVID-19, [키워드] center children clinical picture conducted cough COVID-19 disease COVID-19 infection criteria disease feature Fever help immunization Jeddah Laboratory parameters management Mild nonspecific Novel coronavirus Patient pediatric Pediatric case Pediatric patient presenting required Result Retrospective study risk SARS-COV-2 infection Saudi Arabia Shortness of breath study inclusion study participant Supportive treatment Symptom with COVID-19 [DOI] 10.1155/2021/9918056 PMC 바로가기 [Article Type] Research Article
Dynamics of the SARS-CoV-2 nucleoprotein N-terminal domain triggers RNA duplex destabilizationSARS-CoV-2 핵단백질 N-말단 도메인의 역학은 RNA 이중체 불안정화를 유발합니다Article Published on 2021-07-202022-09-11 Journal: Biophysical Journal [Category] SARS, 치료법, [키워드] 1:1 stoichiometry acute respiratory syndrome acute respiratory syndrome coronavirus Arm Betacoronavirus betacoronaviruses binding coronavirus dimeric double-stranded driven by dsRNA dsRNAs Dynamics functions information interact MD simulation MD simulations molecular molecular dynamics monomeric N protein N-terminal domain nonspecific nucleocapsid Protein raising Regulatory responsible RNA severe acute respiratory syndrome Coronavirus Support the SARS-CoV-2 Transcription transcriptional regulatory sequence Trigger triggering TRS viral genome [DOI] 10.1016/j.bpj.2021.06.003 PMC 바로가기 [Article Type] Article
The impact of the COVID-19 pandemic on stress, mental health and coping behavior in German University students – a longitudinal study before and after the onset of the pandemicResearch Published on 2021-07-132022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] alteration Anxiety Behavior patterns Care change consequence Contact COVID-19 COVID-19 pandemic Depression distribution female Germany Health healthy infected with SARS-CoV-2 infection with SARS-CoV-2 less male Mask mental health moderate no significant difference nonspecific offer pandemic Perceived stress preventive measures proportion Psychosocial stress reported Result risk significant difference Stress student students subgroups supplementary material Symptom Symptoms Taking timepoint timepoints university student washing hand wearing [DOI] 10.1186/s12889-021-11295-6 PMC 바로가기 [Article Type] Research
Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity비특이적 면역을 작동시키는 식물 다당류 나노 입자의 항 바이러스 잠재력Article Published on 2021-07-012022-08-31 Journal: International journal of biological macromolecules [Category] 치료제, [키워드] acting activate anti-bacterial activity Anti-viral antiviral activity ATP cells Compound compromise COVID-19 drug ENhance HL-60 cells Immune modulator. Immunity indol Infection infections MIF non-specific nonspecific nonspecific immunity pandemic Particle phagocytosis physiological polysaccharide polysaccharides proinflammatory secretion Serotonin shown Society the cells the epidemic Trial Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.135 PMC 바로가기 [Article Type] Article
Theoretical Framework for Retrospective Studies of the Effectiveness of SARS-CoV-2 VaccinesSARS-CoV-2 백신의 효과에 대한 후향적 연구를 위한 이론적 틀Review Published on 2021-07-012022-09-11 Journal: Epidemiology (Cambridge, Mass.) [Category] SARS, 치료기술, [키워드] Analysis analytical sensitivity association Bia can not Care Case-control causes controls COVID-19 criteria dataset datasets diagnostic Effect Effectiveness estimate estimation framework include individual introduced Misclassification natural history nonspecific observational studies observational study parameter positive Prevent public health receive reduce risk of infection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines stages Study design Surveillance Symptom threat vaccination Vaccine Validity [DOI] 10.1097/EDE.0000000000001366 PMC 바로가기 [Article Type] Review
TBK1 and TNFRSF13B mutations and an autoinflammatory disease in a child with lethal COVID-19Case Report Published on 2021-07-012022-10-04 Journal: NPJ Genomic Medicine [Category] 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome autoinflammatory disease Autoinflammatory syndrome cardiac insufficiency children Combination coronavirus coronavirus disease COVID-19 CVID death Deleterious disorder etiology Exome Factor Genetic testing homozygous homozygous missense variant immunodeficiency Infection methotrexate Mild Mutation nonspecific occurred parent Prednisolone SARS-CoV-2 Seizure Sequencing severe COVID-19 Symptoms TBK1 TNFRSF13B treated Treatment variant variants viral infection [DOI] 10.1038/s41525-021-00220-w PMC 바로가기 [Article Type] Case Report
Can SARS-CoV-2 Induce Uterine Vascular Anomalies and Poor Contractile Response?—A Case ReportCase Report Published on 2021-06-292022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] Anomaly Arterial hypertension atonia atony of uterus Can conditions COVID-19 discharged Evolution fibrin deposit gravida hypertension hypertensive Infection ischemic lesion lesion male maternity morphological finding nonspecific pathology Patient Placenta polymerase chain Poor positive postoperative Postpartum postpartum hysterectomy Pregnancy Premature report required resources respiratory reverse transcription RT-PCR Saint SARS-CoV-2 score subtotal hysterectomy symptomatic tested umbilical uterine was performed [DOI] 10.3390/medicina57070670 PMC 바로가기 [Article Type] Case Report
Effect of Aprotinin and Avifavir ® Combination Therapy for Moderate COVID-19 PatientsAprotinin 및 Avifavir ® ® 조합 요법의 중간 정도 Covid-9 환자의 효과Brief Report Published on 2021-06-272022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Aprotinin AVIFAVIR body temperature caused clinical status Cohort cohorts Combination combination therapy combinations Concentration contagious coronavirus COVID-19 CRP D-dimer discharge drugs Effect Efficacy Favipiravir HCQ hospital hospitals Hydroxychloroquine ICU inflammatory disease inhibitor intensive care intensive care unit intravenous IQR laboratory-confirmed lung lesion lung lesions median time Ministry of Health moderate Moderate COVID-19 moderate COVID-19 patients nonspecific normalization participant Patient patients per day Pneumonia respiratory SARS-CoV-2 Serine serine protease severe acute respiratory syndrome Coronavirus single-center study the median therapy transfer Treatment [DOI] 10.3390/v13071253 PMC 바로가기 [Article Type] Brief Report
A novel anti‐inflammatory treatment for bradykinin‐induced sore throat or pharyngitisOriginal Article Published on 2021-06-212022-10-30 Journal: Immunity, Inflammation and Disease [Category] Coronavirus, MERS, SARS, [키워드] A549 cells absence acetyl acetyl salicylic acid alveolar analyzed antibiotic Aspirin bradykinin complex mechanism concentrations COVID‐19 COX described disease Epiairway epithelia epithelial cell exacerbate exacerbated Health IL‐8 immunohistochemistry increase in Inflammation Inflammatory inflammatory condition inflammatory mediator ingredient inhibitor involved lactate dehydrogenase LDH likelihood low dose LTB4 medication mitigate morphology MucilAir nonspecific PGE2 pharyngitis prostaglandin public health Respiratory complications respiratory epithelia respiratory tissue respiratory tissues Result sore throat stimulated Symptom TEER the cell therapeutic window therapy thought tissue transepithelial electrical resistance Treatment treatment effect upper respiratory was measured were used [DOI] 10.1002/iid3.479 PMC 바로가기 [Article Type] Original Article
Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1Research Article Published on 2021-06-162022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Basis binding C terminus coronavirus crystal structure fluorescent full-length function functional fusing host mRNA host protein inhibit inhibitory mRNA N terminus N-terminal nonspecific nsp1 pathogenic Protein protein translation restored ribosome ribosomes SARS-CoV SARS-CoV-2 significantly translation weakened [DOI] 10.1128/Spectrum.00169-21 PMC 바로가기 [Article Type] Research Article