Only One Isoform of Drosophila melanogaster CTP Synthase Forms the CytoophidiumDrosophila melanogaster CTP Synthase의 단 하나의 Isoform이 Cytoophidium을 형성합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ATP ATP synthase Author Bacteria biogenesis biological processe biological processes block Cell cell types cells conserved cytoplasm demonstrated different disrupt disrupting dissect distribution DNA and RNA domain Drosophila Drosophila melanogaster ectopic expression embryos energy metabolism enzyme example expression expression profiles form growth human cells identify independent induce isoform locus metabolism Mitochondria mutants Mutation nucleotide nucleotides nucleus organism overexpression provide shown Structure subcellular distribution subcellular structure Synthase synthase gene transcript while yeast [DOI] 10.1371/journal.pgen.1003256 PMC 바로가기 [Article Type] Research Article
A Mechanism of Gene Amplification Driven by Small DNA Fragments작은 DNA 조각에 의한 유전자 증폭 메커니즘Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amplification amplified amplify annealing Author Cancer cancer cell Cancer cells capture cause Cell chromosomal chromosomal DNA chromosomal region contribute copy number degenerative dependent on detected disorders DNA DNA amplification DNA fragment driving duplication Efficiency elevated event events expression Extracellular Factor favor found fragment Frequency gene amplification Genetic variation genomic homology Human increase independent independent of initiated involved loci mechanism molecular molecular mechanism molecular mechanisms nucleotide nucleotides occur oligonucleotide Organisms Patients with cancer polymorphism Rad1 Rad51 Rad52 regions S. cerevisiae Saccharomyces cerevisiae serum single-stranded stimulate Trigger triggered Variation yeast [DOI] 10.1371/journal.pgen.1003119 PMC 바로가기 [Article Type] Research Article
The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-QuadruplexesResearch Article Published on 2009-05-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome ADP-ribose amino-acid Apoptosis Author bats bind binding coding compared component concerning coronavirus crystal structure determine determined different domain Evidence extreme form found function functional G-quadruplex gel electrophoresis Genome genomic RNA help homodimer host cell humans immune response in vitro include Infected involved lysine macrodomain mild infection monomer mRNA Mutation non-structural protein nucleic acid nucleotides nucleus occur oligonucleotide other coronaviruses outbreak pathogenicity Possible Protein protein 3 reduction Region regulate related virus remained Replication residue residues responsible RNA SARS Coronavirus SARS-CoV selected Seven shown Signal transduction Structure structures target three-dimensional structure Transcription viral infection viral replication virus X-ray crystallography [DOI] 10.1371/journal.ppat.1000428 PMC 바로가기 [Article Type] Research Article
Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombinationShort Report Published on 2008-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] 3CL pro Analysis analyzed circulating Comparative compared coronavirus Coronaviruses different DPI Evolution found Genes Genome genomic RNA genomic sequence Gray IBV identity Infectious Bronchitis Virus intergenic region nucleotides occur occurred open reading frames other coronavirus Point mutation polymerase Possible proteinase RdRP Recombination recombination event sequence Sequence analysis sequenced similarity spike gene strain Strains UTR virulent [DOI] 10.1186/1743-422X-5-157 PMC 바로가기 [Article Type] Short Report