Long Term Culture of Human Kidney Proximal Tubule Epithelial Cells Maintains Lineage Functions and Serves as an Ex vivo Model for Coronavirus Associated Kidney InjuryResearch Article Published on 2020-06-292023-07-01 Journal: Virologica Sinica [Category] SARS, [키워드] Angiotensin-converting enzyme 2 (ACE2) Conditionally reprogrammed cells (CRCs) Kidney proximal tubule epithelial cells (KPTECs) organoids SARS-CoVs [DOI] 10.1007/s12250-020-00253-y PMC 바로가기 [Article Type] Research Article
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial CellsArticle Published on 2020-06-192023-07-02 Journal: Cell Reports [Category] SARS, [키워드] human intestinal epithelial cells IFN interferon Interferon lambda interferon stimulted genes intrinsic immunity ISGs organoids SARS-CoV-2 [DOI] 10.1016/j.celrep.2020.107863 PMC 바로가기 [Article Type] Article
Conditional cell reprogramming for modeling host‐virus interactions and human viral diseasesReview Published on 2020-06-162022-10-30 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] abnormality acute respiratory syndrome air‐liquid interface animal Antiviral antiviral drugs biopsies Cancer Cell Cell culture cell line cell senescence cell type cellular senescence change conditional reprogramming Conventional coronavirus Culture develop disease doubling Drug discovery emerging viruses Epigenetic example function functional models Genetic genetic manipulation high variability Host host cells Human in vivo infections innate immune response Interaction invasive Lineage maintain nasal noninvasive normal cells organoids passage passages physiological conditions receptor Replication Research specimens surgical specimens tissue Vaccines viral disease viral entry virus [DOI] 10.1002/jmv.26093 PMC 바로가기 [Article Type] Review
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19Review Published on 2020-05-272022-10-28 Journal: Theranostics [Category] COVID-19, MERS, SARS, [키워드] accelerate Antiviral antiviral drug bioengineering Cell Cell culture Community coronavirus COVID-19 Culture group identify International mechanism organoids Preclinical Testing provide Research SARS-CoV-2 SARS-COV-2 infection target therapeutic agent tissue Vaccine Vaccines [DOI] 10.7150/thno.47406 PMC 바로가기 [Article Type] Review
Salmonella Enteritidis Effector AvrA Suppresses Autophagy by Reducing Beclin-1 Protein살모넬라 엔테리티디스 효과 인자 AvrA는 Beclin-1 단백질을 감소시켜 자가포식을 억제한다.Original Research Published on 2020-04-172024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] autophagy effector Infection organoids Paneth cells [DOI] 10.3389/fimmu.2020.00686 PMC 바로가기 [Article Type] Original Research
Harnessing the Potential of Stem Cells for Disease Modeling: Progress and PromisesReview Published on 2020-02-062023-08-30 Journal: Journal of Personalized Medicine [Category] E형 간염, [키워드] computational cell modeling Gene therapy Genome editing iPSCs Organ-on-a-chip organoids tissue engineering [DOI] 10.3390/jpm10010008 PMC 바로가기 [Article Type] Review
Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2Article Published on 2020-01-012023-07-05 Journal: ALTEX [Category] SARS, [키워드] brain organoids. COVID-19 immunohistochemistry Microphysiological systems NEUROLOGY neurotropism organoids SARS-CoV-2 [DOI] 10.14573/altex.2006111
Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagyarticle Published on 2019-11-302024-09-01 Journal: Autophagy [Category] 살모넬라증, [키워드] autophagy Bacteria Colitis HMGB1 IBD organoids STAT3 [Article Type] article
HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research modelsReview Published on 2019-07-182023-06-02 Journal: BMC Cancer [Category] B형 간염, [키워드] cell cycle Hepatitis B virus Liver cancer organoids Wnt signalling [DOI] 10.1186/s12885-019-5916-6 PMC 바로가기 [Article Type] Review
Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancyOct1/Pou2f1은 결장 재생에 선택적으로 필요하며 결장 악성 종양을 조절합니다.Research Article Published on 2019-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele blocked Cancer Cell Characteristics ChIPseq Colon Colon cancer colon carcinoma Colorectal Colorectal cancer damage death deleted Deletion determine dextran diagnosed differentially expressed differentially expressed gene Differentially expressed genes disease driven by Effect etiology expressed Factor gastrointestinal tract Gene Expression gene target Gut gut stem cell homeostasis identify in vitro in vivo incidence intestinal stem cell Intestinal stem cells maintain maintenance malignancy mechanism metabolism mitotic Mortality Organoid organoids outcome outcomes overlap passage pathophysiology Patient Physiology Pou2f1 preserved proceed promote protein level regulate required significantly sodium sodium sulfate stability stem cell stem cells Stress stress response sulfate Suppressor gene target gene Target genes targets The United States transcription factor Treatment Tumor tumor suppressor tumor suppressor gene United States [DOI] 10.1371/journal.pgen.1007687 PMC 바로가기 [Article Type] Research Article