No excess mortality among working-age Italians during the Omicron wave of Covid-19Article Published on 2022-06-282022-11-16 Journal: La Medicina del lavoro [Category] COVID19(2023년), SARS, 변종, [키워드] age caused circulating death defined Delta Delta wave estimate expected individual Italian Italy Mortality mortality data omicron over pandemic Poisson regression models predominant provide reported variant of SARS-CoV-2 were used [DOI] 10.23749/mdl.v113i3.13092 PMC 바로가기
Who is pausing immunosuppressive medication for COVID-19 vaccination? Results of an exploratory observational trialObservational Study Published on 2022-06-222022-10-05 Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 임상, [키워드] addition age asked baseline Characteristics condition contribute COVID-19 COVID-19 vaccination drug Drug adherence Drug compliance Evidence exploratory Gender immunization immunogenicity Immunosuppressed Immunosuppression immunosuppressive Immunosuppressive medication individual lack medication over participant Participants Patient Person physician prospective observational study questionnaire receive receiving Registered reported Result risk SARS-CoV-2 SARS-CoV-2 vaccination significantly more therapy Trial underlying disease vaccination women worsening [DOI] 10.1186/s40001-022-00727-7 PMC 바로가기 [Article Type] Observational Study
Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 PandemicCOVID-19 전염병의 첫 해 동안 아칸소에서 소아 SARS-CoV-2 혈청 유병률Article Published on 2022-06-222022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Adults age antibody association Characteristics Child children clinical care clinics coronavirus coronavirus disease Coronavirus-2 COVID-19 determine Effect Epidemiology ethnic disparity focus highlight Hispanic hospital infected with SARS-CoV-2 lack multivariable regression model multivariable regression models over pandemic Participants pediatric public health Racial racial disparity Recognition Research respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 seroprevalence SARS-CoV-2 vaccine SARS-CoV-2 variants serology Seropositivity Seroprevalence serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread spring tested univariable Year [DOI] 10.1093/jpids/piac010 PMC 바로가기 [Article Type] Article
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting Reviews Published on 2022-06-212022-10-05 Journal: Nature reviews. Rheumatology [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] approaches autoinflammatory disease cells characterized clinical feature clinical response clinician conditions diagnostic Diseases disorder dysregulation epidemiological Fever Genotype IL-1 include innate immune innate immune system mechanism mouse model mutant over Pathogenesis pathogenic mutations pathophysiological Patient patients Perspective Phenotypes regulated rheumatologist specific diseases subsequent syndrome systemic inflammation targeted therapy therapeutic targeting therapy [DOI] 10.1038/s41584-022-00797-1 [Article Type] Reviews
Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability vaccine booster vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article
Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study처음 두 파동 동안 케냐 해안에서 SARS-CoV-2의 전송 네트워크: 후향적 게놈 연구Article Published on 2022-06-142022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Africa AID analysed Analysis B.1.1 city collected Commonwealth coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 development dispersal Diversity Epidemiology expressed followed by force Foreign genomic Genomics global health Government Health Infection infections Infectious disease International Intervention Kenya Lamu Lineage lineage B.1 lineages Local local public health Microbiology Mombasa MOST NIHR occurred office over pandemic phylogeographic analysis positive sample reduce Research resulting retrospective river SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 virus sequenced severe acute respiratory syndrome Coronavirus Spread study period sub-Saharan Africa Support Taita Transmission transmission pattern Travel UK Government virus viruses Wave [DOI] 10.7554/eLife.71703 PMC 바로가기 [Article Type] Article
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environmentsResearch article Published on 2022-06-012022-10-05 Journal: Life Sciences in Space Research [Category] 비임상, [키워드] accelerate addition adverse effect approach Biomarker Biomarkers Cancer Cancer patients cellular pathway chronic Critical develop Effect help human population Infectious disease Initially involved kill medical countermeasure Medical countermeasures NASA National Cancer Institute NIAID nuclear organization over overlapping physician Population PROTECT provided Radiation Radiation dose radiation exposure radiological reduce Research Space subject supported sustained terrestrial tissue tissues translation Treatment Tumor tumor cell tumors [DOI] 10.1016/j.lssr.2022.06.004 [Article Type] Research article
A Tale of Trial and Triumph: Molecular Diagnostics for Severe Acute Respiratory Coronavirus 2 Over the First Two Years of the Coronavirus Disease 2019 Pandemic시련과 승리의 이야기: 코로나바이러스 질병 2019 대유행의 첫 2년 동안의 중증 급성 호흡기 코로나바이러스 2에 대한 분자 진단Editorial Published on 2022-06-012022-09-11 Journal: Clinics in laboratory medicine [Category] MERS, 유전자 메커니즘, 진단, 치료기술, [키워드] coronavirus 2 over respiratory Year [DOI] 10.1016/j.cll.2022.04.001 PMC 바로가기 [Article Type] Editorial
Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in AustraliaSARS-CoV-2 변이체의 분리 및 특성화를 위한 플랫폼으로 호주에서 Omicron의 신속한 특성화 가능Article Published on 2022-06-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 characterization characterized circulating coronavirus COVID-19 pandemic detect diagnostic evade facilitated Isolation Nasopharyngeal swab nasopharyngeal swabs neutralization antibodies Neutralization antibody Neutralizing antibodies omicron over platform quarantine respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Surveillance swabs TMPRSS2 variant variants of SARS-CoV-2 Viral viral variant VoC [DOI] 10.1038/s41564-022-01135-7 PMC 바로가기 [Article Type] Article
Advances in Clinical Cardiology 2021: A Summary of Key Clinical Trials임상 심장학의 발전 2021: 주요 임상 시험 요약Review Published on 2022-06-012022-09-11 Journal: Advances in therapy [Category] 임상, [키워드] Acute coronary syndrome acute coronary syndromes advance AHA American Heart Association angiography antiplatelet Antiplatelets Aortic valve Atrial fibrillation Cardiac arrest Cardiology cardiovascular clinical clinical trial clinical trials clinicians and researchers college Community Coronary Coronary artery Coronary artery disease Coronary revascularisation Course COVID-19 drug Electrophysiology European evaluated Evidence for inclusion Glucose heart heart failure hospital hypertrophic cardiomyopathy inhibitors International Intervention left Left atrial appendage closure lipids mavacamten Mechanical Mechanical support mitral Mitral clip Myocardial infarction New over PCSK9 Percutaneous prevention Pulmonary valve Quantitative rhythm Sacubitril sacubitril/valsartan SCAI Shock Society sodium Summit technology Therapeutics Transcatheter Transcatheter aortic valve implantation Transcatheter tricuspid valve interventions. Treatment Trial tricuspid tricuspid valve valsartan valve replacement [DOI] 10.1007/s12325-022-02136-y PMC 바로가기 [Article Type] Review