T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern우려되는 SARS-CoV-2 변이체에 대한 융합 억제 리포펩티드의 효능Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] affected antibodies antiviral efficacy Beta causative agent concern conformational conserved convalescent COVID-19 cross-protective described dimeric doses effective Efficacy elicited evade expected ferret ferrets FIVE Frequency fusion inhibitor Immunity in vitro in vivo Infection Intervention less lipopeptide mechanism of action monoclonal antibody monoclonal antibody therapy monomeric neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody peptide peptides postvaccination postvaccine sera potency Protein Receptor binding Receptor-binding domain reported resulting S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 variant selective selective pressure selective pressures sera Seven shown spike Spike protein Spread strain the receptor-binding domain therapeutic therapy vaccination Vaccine variant Viral viral entry viral evolution viral infection virus virus neutralization assays VoC VOCs Waves [DOI] 10.1128/mbio.01249-22 PMC 바로가기 [Article Type] Article
Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다Article Published on 2022-06-282022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used [DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article
A unique antigen against SARS-CoV-2, Acinetobacter baumannii, and Pseudomonas aeruginosaSARS-CoV-2, Acinetobacter baumannii 및 Pseudomonas aeruginosa에 대한 고유 항원Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Acinetobacter antibody Antigen antigenic peptide antimicrobial approved autoimmune responses Characteristics Consensus COVID-19 domain effective vaccine Effective vaccines epitope Epitopes expected FIVE Hospital admissions infections involved linear epitope Neutralizing Nosocomial infections OmpA outbreak P. aeruginosa pathogenicity peptides protective antibodies Protective antibody Pseudomonas aeruginosa raise replaced retained risk SARS-CoV-2 selected selected epitope Selected epitopes sequence Spike protein strain Treatment turn unique variants of SARS-CoV-2 were used [DOI] 10.1038/s41598-022-14877-5 PMC 바로가기 [Article Type] Article
Peptide mediated colorimetric detection of SARS-CoV-2 using gold nanoparticles: a molecular dynamics simulation study금 나노입자를 이용한 SARS-CoV-2의 펩티드 매개 비색 검출: 분자 역학 시뮬레이션 연구Article Published on 2022-06-242022-09-11 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding Clinical diagnosis colorimetric detection coronavirus COVID-19 detection domain enzyme gold Gold nanoparticle host cell host cell membrane in silico interact Interaction investigated methodology molecular molecular dynamics Molecular dynamics simulation outbreak peptide peptides RBD receptor Receptor-binding domain resulting SARS-CoV-2 SARS-CoV-2 antigen screened selective severe acute respiratory syndrome Coronavirus spike Spike protein spike protein of SARS-CoV-2 spikes stability the spike protein virus [DOI] 10.1007/s00894-022-05184-x PMC 바로가기 [Article Type] Article
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike진화하는 SARS-CoV-2 계통에 걸친 펩티도돔 감시, 스파이크에서 T 세포 에피토프 손실 가능성이 가장 큰 변이체 중 뉴클레오캡시드에서 HLA 결합 보존 밝혀Article Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Analysis Antigen B.1.1.529 binding candidate caused CD4+ T cell CD4+ T cells CD8+ comprehensive analysis concern conservation conserved Course COVID-19 disease dominant elicit epitope Epitopes Evidence Genome GISAID heterogeneity HLA immune response immune responses instance interest lineages Loss MOST Mutation N protein N proteins NCBI NIH nucleocapsid omicron pandemic peptide peptides performed Potential predicted Protein protein sequence provided Region remained S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage spike sustained T cells T-cell the N protein the S protein unique vaccination variant variants viral evolution viral variant Viral variants VoC VOCs Volume [DOI] 10.3389/fimmu.2022.918928 PMC 바로가기 [Article Type] Article
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance약물 내성을 예측하고 피하기 위한 SARS-CoV-2 주요 프로테아제의 기질 외피 정의Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral therapies antiviral therapy antivirals binding cleavage Clinical use COVID-19 pandemic Critical drug resistance effective Efficacy elements enzyme Enzymes High-resolution identify inhibitor inhibitors M pro maturation morbidity and mortality Mutation nine peptide peptides polymerases predict promote protease Protease inhibitor protease inhibitors Proteases resistance mutations robust SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variant SARS-CoV-2 variants severe disease Spread Structure susceptible to define treatment strategy Vaccine viral pathogen [DOI] 10.1038/s41467-022-31210-w PMC 바로가기 [Article Type] Article
Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemicSARS-CoV-2의 스파이크 조각이 구피 포에실리아 망상체의 게놈 불안정성과 DNA 손상을 유발할 수 있습니까? COVID-19 전염병의 예상치 못한 영향Article Published on 2022-06-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] animals Brain Can catalase correlated COVID-19 COVID-19 pandemic demonstrated dismutase dispersal DNA damage ecosystem Effect ENA evaluate Frequency Freshwater fish gel electrophoresis genomic genotoxic genotoxicity Impact increase in induce knowledge lipid peroxidation liver malondialdehyde mutagenic Mutagenicity New coronavirus nuclear Olive Organisms parameter peptide peptides Protein raised reduction reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles significantly Single Cell Spike protein Superoxide Superoxide Dismutase tail the Spike Toxicity Viral particles water Water pollution [DOI] 10.1016/j.scitotenv.2022.153988 PMC 바로가기 [Article Type] Article
T-Cell Defects Associated to Lack of Spike-Specific Antibodies after BNT162b2 Full Immunization Followed by a Booster Dose in Patients with Common Variable Immune Deficiencies공통 가변 면역 결핍증 환자에서 BNT162b2 완전 면역 후 추가 용량 투여 후 스파이크 특이적 항체의 결핍과 관련된 T-세포 결함Article Published on 2022-06-142022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abnormality absence anti-SARS-CoV-2 IgG antibody Antibody Response Autoimmune Autoimmunity BNT162b2 booster booster dose CD40L CD8+ central memory circulating common Common variable immune deficiencies complex contributed COVID-19 CVID cytokine expression defect did not produce disease phenotype dose evaluated expressing expression followed by Frequency healthy donor IFNγ IgA IgA antibodies IgG immunization lung damage lymphocyte counts memory B memory B cells mRNA vaccine naïve of BNT162b2 Patient peptides Peripheral blood Responder SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibody specific antibody spike Spike protein T cell T-cell T-cells T-cells response Testing the patient TNFα Vaccine vaccine dose variable virus spike protein was performed [DOI] 10.3390/cells11121918 PMC 바로가기 [Article Type] Article
A database of anti-coronavirus peptides항코로나바이러스 펩타이드 데이터베이스Article Published on 2022-06-132022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 치료제, [키워드] AMPs antimicrobial peptide antimicrobial peptides articles caused collected Coronavirus infection Coronaviruses COVID-19 database demonstrated description disease domain Epidemic help in vitro in vivo information inhibitory effect Inhibitory effects MOST Novel coronavirus peer-reviewed peptide peptides portal researcher Treatment unique vivo assays [DOI] 10.1038/s41597-022-01394-3 PMC 바로가기 [Article Type] Article