Ca2+-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxinsCa2+-의존성 폐렴사슬알균 독소의 구멍 복구: 세균 구멍 형성 독소에 대한 숙주 세포 방어의 새로운 패러다임journal-article Published on 2015-09-012024-08-04 Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research [Category] 폐렴구균 감염증, [키워드] Annexin calcium Non-immune defense plasma membrane [DOI] 10.1016/j.bbamcr.2014.09.005 [Article Type] journal-article
Role of the lipid rafts in the life cycle of canine coronavirusStandard Published on 2015-02-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] Antiviral Antiviral strategies canine cell entry cell membrane cell membranes cholesterol complex Concentration coronavirus Coronaviruses disrupt dose-dependent dose-dependent reduction enveloped RNA virus host cells in viral Infection infection rate infections inhibitory inhibitory effect involved Lipid lipid composition lipid metabolism mechanism membrane modulate plasma membrane Protein Proteins reduction in required role sphingolipids Treatment viral entry viral particle virus virus infectivity was reduced was used [DOI] 10.1099/vir.0.070870-0 PMC 바로가기 [Article Type] Standard
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent MannerResearch Article Published on 2014-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Cell cell entry Clathrin-mediated endocytosis cleavage conformational change coronavirus CoV CoVs demonstrated endocytosed endosomal maturation endosomal pH entry pathway expressing furin furin cleavage site fusion fusion peptide fusion protein gene silencing Genome Host host cell host cell membrane induce Infection influenza A virus inhibited introduced investigated late endosomes less lysosomal protease lysosomal proteases lysosome membrane fusion MERS MERS-CoV MHV microenvironment mouse hepatitis murine hepatitis virus negatively affected occur pathogen plasma membrane predicted previous study promote protease Protease inhibitor Protein proteolytic cleavage Proteolytic processing reporter required S protein shown siRNA Specific the S protein upstream vesicular stomatitis virus virus while zoonotic [DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transportResearch Published on 2014-04-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] absence accumulated acute respiratory syndrome Apoptosis Aprotinin association Brefeldin A carried Cell coronavirus Degradation detect distribution expressed function Golgi immunofluorescence Increased induce lipid droplets lysosomal marker motif mRNA mutant Mutation plasma membrane Protein protein level protein synthesis Proteins residue Result reversed RT-PCR SARS Coronavirus SARS-CoV significantly lower staining subcellular distribution Transcription transfected with translation Transport transported tyrosine viral pathogenesis was performed while wild type [DOI] 10.1186/1743-422X-11-75 PMC 바로가기 [Article Type] Research
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A VirusResearch Article Published on 2011-01-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Acidic Author bypasse bypassed cathepsin L Cell cellular cellular tropism circumvent compared Control cytoplasm described did not reduce Ebola Ebola virus Endocytic pathway ENhance example Express expression Factors Filovirus glycoprotein highly pathogenic IAV IFITM IFITM1 IFITM3 indicate Infection infectious influenza A virus inhibit inhibited innate immune system interfere late stage less limit lysosomal modulate murine observation pathogenic viruses pattern plasma membrane Protein Proteins pseudovirions receptor Replication restrict restriction restriction factor SARS Coronavirus SARS-CoV transmembrane transmembrane protein Treatment viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
Importance of cholesterol for infection of cells by transmissible gastroenteritis virusArticle Published on 2008-09-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] addressed Cell cellular cellular membrane cellular membranes cholesterol compared coronavirus depleting Efficiency enveloped virus expected found gastroenteritis Importance Infection Infectivity involved Lipid rafts membrane plasma membrane Protein question raise reduced significantly TGEV viral envelope virus [DOI] 10.1016/j.virusres.2008.07.023 PMC 바로가기 [Article Type] Article
Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of InfectionResearch Published on 2004-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Actin active site addition atomic Atomic force microscopy Cell change coronavirus cytoskeletal filament Final infected cell Infection involved maturation Microscopy plasma membrane progeny provided Research SARS coronavirus replication SARS-CoV scanning scanning electron microscopy spike Stage virus virus particle virus particles was used [DOI] 10.3201/eid1011.040195 PMC 바로가기 [Article Type] Research