Performance verification of the Abbott SARS-CoV-2 test for qualitative detection of IgG in Cali, Colombia콜롬비아 칼리에서 IgG의 질적 탐지를위한 Abbott SARS-COV-2 테스트의 성능 검증Clinical Trial Published on 2021-09-012022-09-10 Journal: PLoS ONE [Category] SARS, 임상, 진단, 치료기술, [키워드] 95% CI Abbott Accuracy Adequate Affect age Antibody testing Architect Characteristics collected conducted controls COVID-19 symptoms criteria detectable diagnosis of COVID-19 diagnostic Diagnostic accuracy elapsed gold gold standard IgG IgG response IgG test individual INS introduced Local management onset of symptoms option pandemic participant Patient patient group patients with COVID-19 performance plasma sample Population Pre-pandemic plasma samples proportion qualitative detection regulatory agencies regulatory agency Result retrospective RT-PCR SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 test sensitivity Sensitivity and specificity specificity Symptom Symptoms symptoms onset the SARS-CoV-2 validation study verification were used [DOI] 10.1371/journal.pone.0256566 PMC 바로가기 [Article Type] Clinical Trial
Immunometabolic signatures predict risk of progression to sepsis in COVID-19Research Article Published on 2021-08-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95%CI amino acid metabolism Analysis AUC chemokines Clinical finding correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill patients diabetes Diagnosis disease dysregulation early diagnosis Glycolysis help hyperinflammation IL-6 implementation In-hospital individuals Inflammatory cytokines lipid metabolism metabolism metabolite metabolomics Mild mild patient mitochondrial metabolism Mortality multisystemic neutrophil activation NLR Non-COVID-19 patients who survived plasma sample polyamine synthesis predict Prognosis progression quantified risk sensitivity Sepsis sepsis patient septic septic patients Severe patient severity specificity Treatment Type [DOI] 10.1371/journal.pone.0256784 PMC 바로가기 [Article Type] Research Article
Evaluation of Commercial Rapid Lateral Flow Tests, Alone or in Combination, for SARS-CoV-2 Antibody TestingSARS-CoV-2 항체 검사를 위한 상업용 Rapid 측면 흐름 검사 단독 또는 조합 평가Observational Study Published on 2021-08-282022-09-12 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 임상, 진단, [키워드] Abbott acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antibody testing antibody tests Architect collected combined use comparable convalescent plasma convalescent plasma samples coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 infection COVID-19 sample definitive diagnosis diagnosed different time point different time points disease ELISA Euroimmun evaluated Flow greater infections Laboratory tests Lateral lateral flow Microparticle onset of symptoms Patient plasma sample plasma samples Rapid reactivity SARS-CoV-2 sensitivities sensitivity seroprevalence survey Specificities specificity status symptom onset tested Testing the epidemic the United State United States vaccination [DOI] 10.4269/ajtmh.20-1390 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Infection Modulates ACE2 Function and Subsequent Inflammatory Responses in Swabs and Plasma of COVID-19 PatientsSARS-COV-2 감염은 COVID-19 환자의 면봉 및 혈장에서 ACE2 기능 및 후속 염증 반응을 조절합니다.Article Published on 2021-08-282022-09-10 Journal: Viruses [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 gene angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Biomarker change changes in Course COVID-19 Cytokines enzymatic activity enzyme expression function functional Host increase infected patients Infection Inflammation Inflammatory cytokines Inflammatory response Interaction mechanism modulate Nasopharyngeal swab nasopharyngeal swabs plasma plasma sample plasma samples positively correlated receptor Release respiratory response SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-ACE2 severity soluble ACE2 subsequent Swab swabs target cells tested the SARS-CoV-2 virus upper respiratory tract Viral viral entry viral infection Viral load [DOI] 10.3390/v13091715 PMC 바로가기 [Article Type] Article
Sex steroid hormones are associated with mortality in COVID-19 patients Level of sex hormones in severe COVID-19Observational Study Published on 2021-08-272022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] affected age albumin androgen association binding Biobank center coronavirus disease COVID-19 COVID-19 patient Deceased died disease severity estradiol estradiol level hormone hospital Infection interquartile range investigated Level median men men and women Mortality mortality rate Multiple outcome Patient patients with COVID-19 plasma sample residual selected severe COVID-19 Sex sex hormone sex steroid SHBG significantly lower surviving patients Testosterone therapy university were used women [DOI] 10.1097/MD.0000000000027072 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19SARS-COV-2 스파이크 단백질 S1은 섬유소 분해에 내성이있는 피브린 (OGEN)을 유도합니다.Diagnostics & Biomarkers Published on 2021-08-272022-09-01 Journal: Bioscience Reports [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added Blood blood flow change characterized circulation complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 positive patient electron and fluorescence microscopy electron microscopy FIBRIN Fibrin(ogen) fibrinolysis fluorescence microscopy healthy hypercoagulability Hypercoagulation impairment implication induce Infection interfere lung Lungs mass spectrometry Microclot observation ogen Pathologies patients plasma plasma sample plasma samples Platelet platelet-poor plasma Platelets positive patients Protein prothrombin respiratory S1 subunit SARS-CoV-2 spike protein severe acute respiratory syndrome coronavirus 2 Spike protein spike protein S1 Spike protein Sa Treatment trypsinization [DOI] 10.1042/BSR20210611 PMC 바로가기 [Article Type] Diagnostics & Biomarkers
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin장기간 COVID-19/PASC(Post-Acute Sequelae of COVID-19)의 지속적인 응고 단백질 병리는 항플라스민 수치 증가를 동반합니다Original Investigation Published on 2021-08-232022-09-10 Journal: Cardiovascular Diabetology [Category] MERS, SARS, 진단, 치료기술, [키워드] accompanied acute COVID-19 acute infection acute respiratory syndrome acute respiratory syndrome coronavirus amyloid A Antiplasmin Anxiety benefit blood clot Blood clots breath characterized circulating clinical pathologies clotting Coagulopathies Coagulopathy Control control sample coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 phenotype Depression diabetes digested fatigue Fibrin(ogen) fibrinogen fibrinolysis fibrinolytic system fluorescence microscopy healthy individuals Hypercoagulation increase in individual Infection Inflammatory inhibit Long Long COVID/PASC Microclots muscle weakness oxygen oxygen exchange PASC Pathologies pathology Patient pellet persistent plasma plasma sample plasma samples platelet hyperactivation Protein proteomics regime respiratory Result SAA serum amyloid A severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 supernatant Support survivor Symptom Symptoms syndrome therapy Type Type 2 diabetes mellitus Volume weakness [DOI] 10.1186/s12933-021-01359-7 PMC 바로가기 [Article Type] Original Investigation
Detection of Anti-SARS-CoV-2-S2 IgG Is More Sensitive Than Anti-RBD IgG in Identifying Asymptomatic COVID-19 PatientsImmunology Published on 2021-08-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] addition anti-RBD anti-S2 antibody Antibody detection Antibody Response Antibody titer Asymptomatic asymptomatic infection asymptomatic infections asymptomatic patient asymptomatic patients collected contribute correlation Course COVID-19 COVID-19 patients detection dominant elicit Epidemic evaluated feature FIVE identify identifying IgA IgG IgG antibody IgG level IgM IgM antibody ill patient Immunoglobulin imperative improve diagnostics induce isotype linear Neutralizing antibodies neutralizing antibody nucleic acid plasma sample post infection profile Protein provide RBD response responses S2 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2-RBD sensitive sensitivity severely ill patients structural proteins symptomatic infection Symptomatic patients the disease the RBD protein [DOI] 10.3389/fimmu.2021.724763 PMC 바로가기 [Article Type] Immunology
Comparability of six different immunoassays measuring SARS‐CoV ‐2 antibodies with neutralizing antibody levels in convalescent plasma: From utility to predictionBrief Report Published on 2021-08-172022-10-28 Journal: Transfusion [Category] COVID-19, MERS, SARS, [키워드] ACE2 binding acute respiratory syndrome Analysis analyzed antibody Antiviral convalescent coronavirus coronavirus disease correlation COVID‐19 effective Effectiveness evaluated Factor Genscript immunoassay in vitro infections infectious disease testing Intravenous immunoglobulin Linear regression median value Neutralization assay Neutralizing neutralizing antibody neutralizing antibody assays Neutralizing antibody titer outcome plasma plasma sample predict produced provide pseudotype ranged Receiver operator characteristic Result ROC Roche SARS‐CoV‐2 selected sensitivity shown specificity Spike protein therapy utility [DOI] 10.1111/trf.16600 PMC 바로가기 [Article Type] Brief Report
Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화Brief Report Published on 2021-08-112022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19 [DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report