Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Phycobilins as Potent Food Bioactive Broad-Spectrum Inhibitors Against Proteases of SARS-CoV-2 and Other Coronaviruses: A Preliminary StudyMicrobiology Published on 2021-06-102022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against Antiviral Antiviral compound approach approaches binding affinity broad-spectrum inhibitors coronavirus Coronaviruses CoV COVID-19 COVID-19 pandemic CoVs disease effective enzyme Evolution food food bioactive constituents in silico in vitro inhibitor M pro main protease MERS MPro mutant mutant strain Other pandemic coronavirus Papain-like protease Phycobilin PLPro potent protease Proteases reduce Research SARS-CoV-2 therapeutic drug trials United Kingdom Vaccine [DOI] 10.3389/fmicb.2021.645713 PMC 바로가기 [Article Type] Microbiology
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variantSARS-CoV-2 스파이크에서 우성 및 하위 우성 에피토프를 인식하는 단일클론 항체의 중화 효능은 B.1.1.7 변이체의 영향을 받습니다.Article Published on 2021-06-082022-09-10 Journal: Immunity [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Affect antibodies antibody antigenic antigenic drift antigenicity arising Asymptomatic B.1.1.7 B.1.1.7 variant characterized circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants COVID-19 disease COVID-19 disease severity disease severity dominant Donor epitope Epitopes glycan host cell host cells Immune escape impacted individual infected individuals Infectious virus less monoclonal antibodies monoclonal antibody MOST Mutation N-terminal domain NAb NAbs neutralization neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing epitope neutralizing epitopes neutralizing monoclonal antibodies neutralizing monoclonal antibody NTD overlapping plasma potent RBD receptor ACE2 Receptor binding domain recognizing retained S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants SARS-CoV-2-infected individuals specific antibodies spike The B.1.1.7 the RBD the SARS-CoV-2 variant variant of concern variants Viral viral entry [DOI] 10.1016/j.immuni.2021.03.023 PMC 바로가기 [Article Type] Article
Potent phytochemicals against COVID-19 infection from phyto-materials used as antivirals in complementary medicines: a reviewReview Published on 2021-06-022022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] addition Analysis Antiviral authors Ayurveda and Siddha complementary COVID 19 COVID-19 infection COVID-19 pandemic COVID-19 situation Evidence free fatty acid help in silico In silico method Inclusion increase in Indian system of medicine main protease MDs Medicines outbreak outcome performed polyphenols potent produced Regulation Research researcher SARS CoV-2 selected Spike protein Traditional Chinese medicine treat [DOI] 10.1186/s43094-021-00259-7 PMC 바로가기 [Article Type] Review
Discovery of New Potent anti-MERS CoV Fusion InhibitorsPharmacology Published on 2021-06-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] antiviral activity Antiviral agents antivirals binding affinity binding site cell membrane cell-cell fusion cellular Concentration coronavirus CoV cytotoxicity demonstrated domain Drug discovery EC50 fusion fusion inhibitors heptad repeat humans IC50 inhibited MERS-CoV Middle East New peptide plaque potent Prevent profile respiratory syndrome coronavirus Safe Viral pneumonia wild-type zoonotic transmission [DOI] 10.3389/fphar.2021.685161 PMC 바로가기 [Article Type] Pharmacology
Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-05-312022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Against anti-SARS-CoV-2 Anti-viral antibody cocktail Antiviral approach caused Cell characterized competitive binding complex convalescent plasma COVID-19 cross-neutralizing antibody database defined described develop disease effective Efficacy Efficiency effort Evidence FIVE group human-to-human transmission include Infectious disease inhibiting Mechanical mechanisms MERS-CoV mitigate molecular molecular mechanism of action molecular target neutralization neutralizing effect neutralizing monoclonal antibody New coronavirus pandemic potent Pseudotyped virus reported retrieved Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein Spread Therapeutics Treatment Vaccine Vaccines viral spread virus wild-type Wuhan, China [DOI] 10.3389/fmolb.2021.670815 PMC 바로가기 [Article Type] Molecular Biosciences
Potent and Persistent Antibody Response in COVID-19 Recovered PatientsCOVID-19 회복 환자의 강력하고 지속적인 항체 반응Immunology Published on 2021-05-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] Antibody Response caused collected COVID-19 determine displaying ELISA global pandemic IgG IgM individual infected patient Mild moderate N protein neutralization activity neutralization potency patients persistent positive potent presence of antibody pseudovirus purified reached recovered recovered patient recovered patients response robust antibody response robust antibody responses SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein serum sample serum samples significantly specific antibodies spike glycoprotein Support symptom onset Symptoms the antibody response Viral Virus-specific antibody [DOI] 10.3389/fimmu.2021.659041 PMC 바로가기 [Article Type] Immunology
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse ModelImmunology Published on 2021-05-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] biochemically candidate cells characterized Comparative Cytotoxic T cells driving generate glycosylation site humoral immune response immunization immunogenicity immunomodulation immunomodulatory effect Interaction investigated mice Model mouse neutralizing antibody neutralizing epitope potent Potential Protein RBD Receptor binding domain response robust SARS-CoV2 specificity spike Spike protein subunit Support T cell Th1 the SARS-CoV-2 the spike protein thermal stability Type unmet need vaccination Vaccine vaccine candidate Vaccine development viral entry [DOI] 10.3389/fimmu.2021.641447 PMC 바로가기 [Article Type] Immunology
Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human PrimatesPlant Science Published on 2021-05-132022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] acute respiratory syndrome administration affected affinity column approved caused clinical trials coronavirus coronavirus disease COVID-19 demonstrated domain effective elicited enzyme-linked immunospot assay expressed Fc fragment Fc fusion protein fused global public health human IgG1 IFN-γ immune response immunized mice intramuscular investigated knowledge mice neutralization titer Nicotiana benthamiana Non-human non-human primates plant-produced recombinant protein potent primate Protein protein A purified RBD RBD of SARS-CoV-2 RBD-Fc RBD-Fc fusion protein Receptor-binding domain response SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 RBD protein spreads Stage subunit Subunit vaccine the disease Vaccine vaccine candidate [DOI] 10.3389/fpls.2021.682953 PMC 바로가기 [Article Type] Plant Science
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing ResponsesVaccines and Antiviral Agents Published on 2021-05-072022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] ACE2 antibody B.1.351 binding conformational conformations described epitope expected Glycoproteins immune response Immunity immunization immunized include individuals induce inhibit Interaction long-lasting majority mRNA vaccine Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing response observation P.1 potent prefusion Prevent Protein raised RBD receptor Receptor binding domain receptor binding site recruit response robust S protein SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 variants sequence sera spike Spike protein spikes stability state T cell response the antibody response the RBD the spike protein trimer trimeric S protein Vaccination strategy Vaccine Vaccines variants variants of concern viral spike protein virion [DOI] 10.1128/JVI.00203-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents