Primary infection – Page 8 – Communicable Diseases Research

Cardiovascular Impacts on COVID-19 Infected Patients

Cardiovascular Medicine

Published on 2021-05-132022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

강력한 SARS-CoV-2-특이 T 세포 면역은 1차 감염 후 6개월 동안 유지됩니다.

Article

Published on 2021-05-012022-09-12
Journal: Nature Immunology [Category] Fulltext, SARS, 진단,

Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

SARS-CoV-2 백신 투여 요법의 역학 및 진화적 고려 사항

Research Article

Published on 2021-04-232022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

[키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect antigenic evolution approach approved assumption available dose available doses build building can be used Characteristics clinical evaluation Combination condition consequence continuous spectrum coronavirus country COVID-19 infection COVID-19 infections Critical decrease dependent on determine disease severity distribution dose dosing regimen effective vaccine effort elicited epidemiological equity Evolution example first dose highlight immune Immune escape immune response immune responses Immunity immunized Impact imperative improves in some increase increase in individual individual immunity individuals Infection infections International Intervention long term medium middle mitigate mutations natural immunity Numerous outcome outcomes pandemic parameters phylodynamic population immunity Primary infection problems proportion public policies question rationale receiving reduce reduced replicate respiratory resulting robustness Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 viral Science second dose secondary infections serological data severe acute respiratory syndrome Coronavirus short term single dose single vaccine Spread strength Stress subsequent susceptibility susceptible switching the timing the vaccine trajectory vaccinal vaccination vaccination rate vaccination rates Vaccine vaccine dose Vaccines variants Variation variations Viral viral adaptation viral antigenic evolution Viral load viral loads virus
[DOI] 10.1126/science.abg8663 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

영국에서 항체 음성 의료 종사자와 비교한 항체 양성 환자의 SARS-CoV-2 감염률: 대규모, 다기관, 전향적 코호트 연구(SIREN)

Multicenter Study

Published on 2021-04-172022-09-11
Journal: Lancet (London, England) [Category] MERS, SARS, 진단, 치료기술,

[키워드] 95% CI adjusted Analysis antibody Antibody test antibody test) Antibody testing assigned baseline clinically Cohort cohorts COVID-19 defined Department determined by effective eligible England enrolled enrolment Evidence first positive Follow-up frailty future infection had no hazard health-care hierarchy hospital Immunity incidence incidence density incidence rate include Increased individual individuals induce Infection infection rate infection rates infection with SARS-CoV-2 infections Linked data lower risk median median interval multicentre participant Participants PCR PCR positive PCR test PCR testing PCR tests PCR-confirmed Poisson distribution positive positive PCR positive PCR test Potential Primary infection Primary outcome prospective cohort study protective effect Public Health England questionnaire Questionnaires rate ratios recruited Region Reinfection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Scottish Seroconversion Support Symptom symptomatic and asymptomatic UK Government was done was used were excluded
[DOI] 10.1016/S0140-6736(21)00675-9 PMC 바로가기 [Article Type] Multicenter Study

Immune memory in convalescent patients with asymptomatic or mild COVID-19

Article

Published on 2021-03-252022-10-31
Journal: Cell Discovery [Category] COVID-19,

Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans

내인적으로 생성된 SARS-CoV-2 특이적 IgG 항체는 인간의 1차 감염 동안 바이러스의 비강 배출 제거에 제한적인 영향을 미칠 수 있음

Article

Published on 2021-03-202022-09-01
Journal: Viruses [Category] SARS, 진단,

[키워드] antibody antibody kinetics antigenic antigenic stimulation binding characterized Clearing Clinical severity ENhance Human IgG IgG and IgM IgG antibodies IgG level IgG levels IgM antibodies Immunity Impact Infection isotype Limited mathematical mathematical model Mathematical models Mitigation nasal passage nasal passages natural infection neutralization no effect occur Primary infection production rate resulting SARS-CoV-2 SARS-CoV-2 viral severe disease severity shedding Specific specific IgG antibodies specific IgG antibody specific neutralizing antibodies specific neutralizing antibody symptom onset therapeutic purposes Trigger triggers vaccination Viral viral clearance viral dynamics virus while
[DOI] 10.3390/v13030516 PMC 바로가기 [Article Type] Article

The Importance and Challenges of Identifying SARS-CoV-2 Reinfections

SARS-CoV-2 재감염 식별의 중요성과 과제

Review

Published on 2021-03-192022-09-11
Journal: Journal of Clinical Microbiology [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition challenge Community consequence coronavirus Course COVID-19 described determinants different time point Establishing explain Frequency genomic data help identifying IgG immune protection immune response Immunity Immunoglobulin Importance Infection initial investigators key factor Laboratory less logistics occurred pandemic Patient positive Primary infection Prospective Study question raised raising Reinfection report SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity strength Surveillance Viral genome sequencing viral immunity virus was performed
[DOI] 10.1128/JCM.02769-20 PMC 바로가기 [Article Type] Review

Through The Back Door: Expiratory Accumulation of SARS-Cov-2 in the Olfactory Mucosa as Mechanism for CNS Penetration

Research Paper

Published on 2021-03-152022-10-29
Journal: International Journal of Medical Sciences [Category] COVID-19, SARS,

SARS-CoV-2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the host

SARS-CoV-2/인간 상호작용체는 숙주의 면역 조절 네트워크와 ACE2 유전자좌 누화를 밝힙니다

Article

Published on 2021-02-192022-09-11
Journal: Pathogens and disease [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 receptor ACE2/AGT-axis activating Activation acute respiratory syndrome adrenal gland Altered angiotensin angiotensin-converting enzyme 2 approach axis binding blood pressure body tissues carboxypeptidase Cell cell cycle changes in Complication coronavirus COVID-19 cytokine database determine develop event gene expression profile globe Health help Host host immune system host protein Human human Angiotensin-converting enzyme human lung human tissue immune immune modulation immune response in viral Infection infection site Interaction involved kidneys Lineage locus lung Lungs mechanism mechanisms modulate molecular network Occurrence organs pancreas Placenta Primary infection Protein Proteins proteomic RAS receptor regulated regulatory network Renin renin-angiotensin system Replication respiratory reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Severe acute respiratory syndrome Signal transduction small intestine Spike protein Testis tissues vascular remodelling Viral viral infection viral spike protein
[DOI] 10.1093/femspd/ftab005 PMC 바로가기 [Article Type] Article

Immunological characteristics govern the transition of COVID-19 to endemicity

면역학적 특성은 COVID-19의 풍토병으로의 전환을 지배합니다

Report

Published on 2021-02-122022-09-12
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 진단,

[키워드] accelerate acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adult disease age age distribution Analysis assumption cause Characteristics childhood children common cold component coronavirus COVID-19 disease distribution Elimination Endemic endemic human coronavirus endemic human coronaviruses endemicity Epidemic epidemiological data evaluate groups HCoVs human coronavirus immune response Immunity immunological Mild outcome pandemic predict Primary infection PROTECT question reached Reinfection respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe disease severity Severity of infection shift spreads sterilizing immunity trajectory transition turn vaccination Vaccine virulent virus widespread
[DOI] 10.1126/science.abe6522 PMC 바로가기 [Article Type] Report