Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocolSARS-CoV-2(COVID-19) 양성 중환자에서 보조 요법으로 고용량 아연 정맥 주사에 대한 무작위 대조 시험: 시험 프로토콜Article Published on 2020-12-022022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] Analysis caused Controlled trial coronavirus COVID-19 Critically ill demonstrated discharge distress double-blind duration of follow-up Effect Elemental end-organ Ethical approval Ethics ethics committee evaluate healthcare High-dose hospitalised patient Human hypoxic independent Infectious diseases Injury International intravenous lowest oxygen saturation mechanism non-ventilated patient non-ventilated patients oxygen oxygen saturation oxygen saturations oxygen supplementation Oxygenation pandemic PaO participant peer-reviewed Placebo positive primary outcome measure Primary outcome measures protective effect public health randomised controlled trial recruited recruitment reduction registration number Research Ethics respiratory respiratory distress Respiratory distress syndrome Respiratory illness respiratory infections Result resulting RNA polymerase robust SARS-CoV-2 SARS-COV-2 infection syndrome therapy Treatment trial protocol Vaccine ventilated patient ventilated patients Viral viral respiratory infection viral respiratory infections Virology was obtained Zinc [DOI] 10.1136/bmjopen-2020-040580 PMC 바로가기 [Article Type] Article
Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey: highlighting negative emotionality mechanismsMental Health Published on 2020-11-262022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, SARS, [키워드] 95% CI affected age alcohol Analysis Anxiety Assessing Behavior changes in children country COVID-19 COVID-19 pandemic COVID-19 related stress cross-sectional survey Depression depression & mood disorders disorder drastic driven by Effect English essential worker Factor Factors Future General population habit highlight highlighting include increase in indicated individual International Isolation limitation measure mechanism objective Older participant positive primary outcome measure Psychiatric psychiatry public health quarantine released reported required Result scale Self-isolation setting severity Stress substance misuse urgency virus spread [DOI] 10.1136/bmjopen-2020-044276 PMC 바로가기 [Article Type] Mental Health
Mortality of high-risk orthopaedic oncology patients during the COVID-19 pandemic: A prospective cohort studyObservational Study Published on 2020-11-012022-10-05 Journal: Journal of surgical oncology [Category] SARS, 임상, [키워드] 30-Day mortality acute respiratory syndrome Admission age consecutive patients coronavirus COVID-19 COVID-19 pandemic female FIVE greater immunosuppressive incidence male males measure men Mortality National oncology oncology patient orthopaedic oncology pandemic Patient postoperative Prevent primary outcome measure prospective cohort study prospective observational cohort respiratory complication Sarcoma SARS-CoV-2 SARS-CoV-2 test secondary outcome Symptom tested therapy threshold Tumours Viral transmission [DOI] 10.1002/jso.26127 PMC 바로가기 [Article Type] Observational Study
An investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a (the base therapeutic regimen) in moderate to severe COVID-19: A structured summary of a study protocol for a randomized controlled l trialLetter Published on 2020-10-262022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 accompany Admission age alcohol allocation concealment ALT/AST Arm assigned Beta block-randomization Blood body temperature Care clinical Clinical improvement clinical trial comparator Confirmed control group COVID COVID-19 COVID-2019 CT scan death discharge disease dissemination drug duration of hospitalization Effect Effectiveness element eligibility criteria exclusion criteria fatigue group headache Health High dose High-dose hospital hospital discharge Hospitalization improvement incidence include Infection information Interaction interferon beta Interferon beta-1a Interferon-β 1a intervention group Intubated Invasive mechanical ventilation investigator Kaletra Laboratory results lactating women Last less limit Loghman Hakim Hospital Lopinavir/ritonavir low dose low-dose masking mechanical ventilation Medical Sciences moderate Mortality nasal Non-invasive number objective open label Open-label outcome oxygen saturation oxygen support package parallel group participant Patient pregnant Primary outcome primary outcome measure professional protocol R software Radiation randomised randomization randomization sequence Randomized Randomized controlled trial Randomly receive Recigen recruitment refusal regimen Registered Research respiratory rate Ritonavir RT-PCR RT-PCR test Sample size SARS-CoV-2 sealed secondary secondary outcome seven-category ordinal scale severe disease Shortness of breath single center standard care status Study protocol Symptom the patient therapeutic time treated treatment groups Trial two groups university version 3.6.1 website World Health Organization [DOI] 10.1186/s13063-020-04812-2 PMC 바로가기 [Article Type] Letter
Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUsResearch Published on 2020-10-152022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] Admission Analysis analyzed ARDS cardiovascular complications clinical competing complex Compliance Complication contribute coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient death demonstrated develop enrolled Evolution Factor ICU ICU admission increasing age independent risk factor information intensive care Invasive mechanical ventilation Italian laboratory data mechanical ventilation Mortality multicenter multicenter observational study multiple organ involvement multivariate logistic regression Non-pulmonary observation period Occurrence organ dysfunction outcome Outcomes, mortality PaO Patient patients with COVID-19 Pneumonia primary outcome measure proportion prospective observational study Regression model renal renal replacement therapy Respiration, artificial Respiratory system Result risk risk factor RRT severe respiratory failure SOFA score the disease the patient VAP variable ventilator parameters Ventilator-associated pneumonia ventilator-free day were recorded [DOI] 10.1186/s40560-020-00499-4 PMC 바로가기 [Article Type] Research
The Relation Between Official WhatsApp-Distributed COVID-19 News Exposure and Psychological Symptoms: Cross-Sectional Survey StudyOriginal Paper Published on 2020-09-252022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, [키워드] adopted agency Anxiety app boost conducted coronavirus disease COVID-19 COVID-19 outbreak DASS-21 demographics Depression disseminate effective example exposure global pandemic Government information medium mental health mitigate New objective offer official pandemic participant Predictor variables primary outcome measure promote protective factor Psychological Psychological well-being Psychology public health public well-being question receiving Registration relation replicate Resilience Result risk risk factor severe symptom significantly Singapore social media Stress Stress Scale stress symptom survey these symptom Transmission turn WhatsApp World Health Organization [DOI] 10.2196/22142 PMC 바로가기 [Article Type] Original Paper
Barrier Enclosure for Endotracheal Intubation in a Simulated COVID-19 Scenario: A Crossover StudyEndemic Infections Published on 2020-09-172022-10-29 Journal: Western Journal of Emergency Medicine [Category] COVID-19, MERS, [키워드] 95% confidence interval airway averaged barrier Clinical practice Complication conducted COVID-19 crossover determine Enclosure endotracheal Endotracheal intubation Healthcare provider hospital indicated intubation less median occurred operator operators outcome participant performed primary outcome measure Randomized reduce response Result risk of COVID-19 secondary Spread threshold Transmission Ventilation [DOI] 10.5811/westjem.2020.7.48574 PMC 바로가기 [Article Type] Endemic Infections
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making: a national survey (COVID-CNSMDT Study)Oncology Published on 2020-08-162022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, MERS, [키워드] affected Brain Cancer change change management changed changes in college COVID-19 COVID-19 pandemic group had no Healthcare system Impact impacted Infectious diseases information initial less London maintain majority management mitigate National neurological oncology objective offered oncology outcome measure pandemic participant Patient patients patients without COVID-19 performed pressure primary outcome measure provided receiving Regional Registered Result secondary secondary outcome measure setting study period surgical Treatment tumour Tumours undergo unit Variation Volume [DOI] 10.1136/bmjopen-2020-040898 PMC 바로가기 [Article Type] Oncology
Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemic (Sleep COVID-19): structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-08-082022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] 1:1 Acute insomnia All participant anticipated Anxiety asleep automatically baseline blinded block size brief intervention caused CBT-I clinical Cluster Complete computer-generated conditions conducted control group COVID-19 COVID-19 pandemic criteria Depression Diagnosis disorder dissemination distress DSM-5 Effectiveness Efficacy element English epilepsy follow-up time Good groups healthy hypothesised impairment IMPROVE include individual Insomnia Insomnia Severity Index Intervention intervention group investigator involved ISRCTN Measures number objective occurred Online intervention outcome outcome measure participant PDF Poor post-intervention Prevent primary outcome measure problem problems protocol provided Qualtrics randomisation randomised randomised controlled trial receive recruited recruitment reduce Registered reported Research Sample size SARS-CoV-2 Schizophrenia secondary seeking severity short-term insomnia Sleep Standard status Study protocol Symptom Testing thought Treatment university website Williams [DOI] 10.1186/s13063-020-04644-0 PMC 바로가기 [Article Type] Letter
The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection CasesArticle Published on 2020-07-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval absence age age and sex analyzed area under the curve Cancer cardiac cardiovascular COVID-19 dataset death demographics diabetes died disease disorder doctor Epidemiology Factor female Generalized linear model Health Health Service identify infected patient infected with COVID-19 Intervention Logistic regression logistic regression model Mortality National Neuromuscular other variable Patient Portugal potential risk primary outcome measure public health Ratio reduced Registered risk risk factor risk of death role Sex systemic condition was used with COVID-19 [DOI] 10.3390/jcm9082368 PMC 바로가기 [Article Type] Article