Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeriDanio rerio 및 Allivibrio fischeri에 광유도 공정으로 처리된 로피나비르 및 리토나비르 함유 용수 및 폐수의 독성 공개Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] 치료제, [키워드] Affect affecting antiviral drug antiviral drugs Bacteria Behavior Chronic toxicity Concentration Contact contact with coronavirus disease Coronavirus disease 2019 COVID-19 Danio drug Ecotoxicity edema Efficiency form hospital Impact increase in indicate Inflammation Lopinavir LOPINAVIR AND RITONAVIR Organisms oxidative stress oxygen parameter Photocatalysis Photolysis physicochemical plants predicted problem protocols reduce Ritonavir shortening significantly survival tail toxic effect Toxicity treated Treatment wastewater water zebrafish [DOI] 10.1016/j.scitotenv.2022.153967 PMC 바로가기 [Article Type] Article
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021) Reviews Published on 2022-06-092022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] addition Cancer catalytic Chimera Clinical treatment Compound Degradation disease Diseases immune disorders increase in induce introduced knockdown molecular neurodegenerative problem Protein rapid increase reported Research researcher small molecule target target protein unique viral infections [DOI] 10.1038/s41392-022-00999-9 [Article Type] Reviews
Diagnostic Concordance between the Visual Analogue Anxiety Scale (VAS-A) and the State-Trait Anxiety Inventory (STAI) in Nursing Students during the COVID-19 PandemicObservational Study Published on 2022-06-092022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] analogue Anxiety approach carried collected correlation COVID-19 COVID-19 pandemic cross-sectional detect determine diagnostic false positive rate faster FPR generate inventory Nursing nursing students positive rate Probability problem Quantitative Safe scale socio-demographic STAI state-trait anxiety inventory student threshold variable Visual Visual Analogue Scale visual analogue scale. [DOI] 10.3390/ijerph19127053 PMC 바로가기 [Article Type] Observational Study
mRNA Vaccines: The Dawn of a New Era of Cancer ImmunotherapymRNA 백신: 암 면역 요법의 새로운 시대의 여명Review Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accelerated addition anticancer Cancer cancer treatment Cancer vaccine candidate Candidates clinical trial clinical trials COVID-19 pandemic dawn Delivery system immune immune response immunological immunological mechanism Immunotherapy in vitro transcription inefficient instability malignant tumor malignant tumors mechanisms mRNA mRNA vaccine mRNA vaccines New outbreak past problem problems promoted provide Research research and development SARS-CoV-2 vaccines therapy Treatment Tumor tumors Vaccines [DOI] 10.3389/fimmu.2022.887125 PMC 바로가기 [Article Type] Review
Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19중증 COVID-19 환자 치료에서 토실리주맙과 메틸프레드니솔론의 효능 및 안전성 비교Article Published on 2022-06-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 28-day mortality 95% CI adverse event adverse events alternative caused clinical clinical response comparable COVID Cox regression analysis CRP Dexamethasone dose doses duration of hospitalization Efficacy and safety faster group groups hospitalized patient hospitalized patients ICU admission improvement intravenous methylprednisolone Methylprednisolone not significantly different occurred Other outcome oxygen oxygen saturation Patient Primary outcome problem prospective cohort study secondary Secondary outcomes severe COVID-19 Sleep disturbance Sleep disturbances statistically significant Tocilizumab Treatment were recorded [DOI] 10.1016/j.intimp.2022.108689 PMC 바로가기 [Article Type] Article
Prevalence of eating disorders among Saudi female university students during the COVID-19 outbreakResearch article Published on 2022-06-012022-10-05 Journal: Journal of Taibah University Medical Sciences [Category] 유전자 메커니즘, [키워드] Attitude BMI body mass index change changes in collected college concerning coronavirus disease COVID 19 COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional disorder disorders eating Eating Disorder eating disorders evaluate Factors female genetics high risk KSA media moderate MOST objective pandemic parents participant physical activity problem questionnaire recruited Result risk Risk factors Saudi Arabia Sociodemographic Stress Test [DOI] 10.1016/j.jtumed.2022.02.001 [Article Type] Research article
An overview on parametric quantile regression models and their computational implementation with applications to biomedical problems including COVID-19 dataResearch article Published on 2022-06-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] 유전자 메커니즘, [키워드] applied baseline Brazil covariate COVID-19 data sets distribution distributions example functional functions GLM implementation include Likelihood methods non-normal parameters Parametric Parametric regression problem Quantile Quantile function R package R software random real-world data Regression Regression model regression models response response variable statistical the mean variety with COVID-19 [DOI] 10.1016/j.cmpb.2022.106816 [Article Type] Research article
Advances in nanotechnology application in biosafety materials: A crucial response to COVID-19 pandemicReview article Published on 2022-06-012022-10-05 Journal: Biosafety and Health [Category] 변종, 신약개발, 진단, 치료기술, 치료제, [키워드] advance affected approach biosafety Combination coronavirus disease COVID-19 COVID-19 pandemic develop diagnostics domain effort equipment globe high mortality nanomaterials outbreak overcome Personal protective equipment Perspective PPE problem problems provided Research researcher SARS-CoV-2 synergistic Therapeutics treat Vaccines [DOI] 10.1016/j.bsheal.2022.06.001 [Article Type] Review article
A virtual innovation bootcamp to remotely connect and empower students to solve COVID-19-related medical problems Comments & Opinion Published on 2022-06-012022-10-05 Journal: Nature biotechnology [Category] 진단, [키워드] problem [DOI] 10.1038/s41587-022-01352-9 [Article Type] Comments & Opinion