Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients일시적인 항대사물질 치료 보류는 신장 이식 수혜자의 SARS-CoV-2 백신 접종에 따른 체액성 및 세포성 면역을 향상시킵니다.Article Published on 2022-05-092022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acquisition antimetabolite treatment applied Arm autoimmune disorder B cell boost booster vaccination caused CD4+ T cell cellular immunity COVID-19 cytokine production dose Frequency humoral humoral immune response humoral responses IgG levels Immunity Immunosuppression IMPROVE increase in kidney transplant recipient kidney transplant recipients memory mounted organ transplantation outcomes Patient patients plasmablasts positively correlated programmed cell death proportion protective immunity recent Receptor binding recipient relative frequency remained revaccination SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly increased T cell temporary Transplant vaccination Vaccinations Vaccines virus-neutralizing [DOI] 10.1172/jci.insight.157836 PMC 바로가기 [Article Type] Article
Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection단일 용량 복제 폭스바이러스 벡터 기반 RBD 백신은 SARS-CoV-2 감염에 대한 강력한 체액 및 T 세포 면역 반응을 유도합니다.Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration animal models Antigen approach breath complementary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cynomolgus macaques Dose escalation Efficacy evaluate the effect Express humoral immune immune response immune responses immunogenicity induce long-lasting mice Neutralizing antibodies outbreak pandemic poxvirus protective immunity RBD Receptor binding domain Replication respiratory response robust Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single dose Single-dose Support T cell T cell responses temperature Vaccine vaccine candidate vaccine platform Vaccines vaccinia virus vector [DOI] 10.1016/j.ymthe.2021.10.008 PMC 바로가기 [Article Type] Clinical Trial
A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models자가 증폭 mRNA SARS-CoV-2 백신 후보는 전임상 모델에서 안전하고 강력한 보호 면역을 유도합니다Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] (Alpha) (Beta Alpha animals Antigen B.1.1.7 B.1.351 B.1.617.2 Beta biodistribution breath CD4 CD8 T cell CD8 T cell responses characterized clinical evaluation Delta demonstrated disease dose-dependent manner Efficacy elicit elicited emergency response Evidence evidence of Frequency Germinal center hamsters humans immune responses immunization immunogenicity induce Lipid nanoparticle Lipid nanoparticles LNP lower airways Messenger RNA mice mRNA neutralized no evidence of Phase 1 Protective protective immune response protective immunity RATs reduced response RNA RNA vaccines robust Safe safety profile SAM SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants SARS-CoV-2 Wuhan strain self-amplifying mRNA Spike antigen spike-specific antibody response T cell the SARS-CoV-2 the vaccine Tolerance Toxicity upper and lower airways Vaccine vaccine candidate variants Viral Viral load Wuhan-Hu-1 [DOI] 10.1016/j.ymthe.2022.01.001 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutantsCOVID-19 환자 혈청은 다양한 SARS-CoV-2 RBD 돌연변이에 대한 ACE2-RBD 결합을 덜 강력하게 억제합니다Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2-RBD ACE2-RBD binding Affect Analysis analyzed antibody bead binding classical correlated COVID-19 patient COVID-19 patient serum disease severity displaying E484K E484K mutation examined extension IgG levels immune protection increasingly Infectious virus inhibit Interaction less Longevity mimicking multiplex Multiplex assay mutant NAbs neutralization test neutralization tests Neutralizing activity Neutralizing antibodies positively correlated proceed protective immunity RBD RBDs Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants serological serum sample serum samples severity the RBD therapy vaccination variant variants variants of interest virus neutralization test VoC VOCs VOIs was reduced WHO wild-type [DOI] 10.1038/s41598-022-10987-2 PMC 바로가기 [Article Type] Article
Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection푸린 및 TMPRSS2 내성 스파이크는 SARS-CoV-2 치명적인 감염에 대한 강력한 체액 및 세포 면역을 유도합니다Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice Against Amino acid antibody response against blocked C-terminal CD8 cleavage site clone clones COVID-19 vaccine effective Express furin furin cleavage furin cleavage site hamsters identify in some induce intranasal lethal Mutation mutations produced protective immunity Protein pseudotype Replication replication-competent. Resistant robust S antigen S protein S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant single dose spike Spike protein T cell T cell response the SARS-CoV-2 TMPRSS2 transgenic unmet need vaccination Vaccine Vaccine design variant vesicular stomatitis vesicular stomatitis virus virus VSV was used [DOI] 10.3389/fimmu.2022.872047 PMC 바로가기 [Article Type] Article
Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workersCOVID-19 mRNA 및 벡터 백신에 대한 체액 및 세포 면역 반응의 유도: 불가리아 의료 종사자를 대상으로 한 전향적 코호트 연구Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] advanced age age anti-SARS-CoV-2 immune responses anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines BNT162b2 Bulgarian cellular Cellular immune response circulating Cohort comparable Complete coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 vaccine Donor donors dose Enumeration evaluated healthcare worker humoral humoral immune response IFNγ IgA immune responses Immunity immunization Immunoglobulin immunoglobulin A increased risk induce induction Infection Installing interferon gamma Longevity Messenger RNA mRNA mRNA vaccine Neutralizing activity neutralizing antibody overcome Pandemics participant peaking priming prospective cohort study protective immunity Receptor-binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 specific T-cell significantly single dose T cell T cells tested Vaccine vaccine cohort virus-neutralizing virus-neutralizing antibody virus-neutralizing antibody. [DOI] 10.1002/jmv.27572 PMC 바로가기 [Article Type] Article
The COVID-19 Humoral Immunological Status Induced by CoronaVac and AstraZeneca Vaccines Significantly Benefits from a Booster Shot with the Pfizer VaccineCoronaVac 및 AstraZeneca 백신으로 유발된 COVID-19 체액 면역학적 상태는 화이자 백신으로 추가 접종을 하면 상당한 이점이 있습니다Article Published on 2022-04-272022-09-12 Journal: Journal of Virology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition antibody Antibody Response Antiviral antiviral antibody AstraZeneca benefit booster booster shot Brazil CoronaVac country COVID-19 Critical decrease defined distribution dose Effectiveness ELISA enzyme-linked immunosorbent evaluate humoral Humoral immunity immunization immunological indicate individual induce induced infected individual natural infection participant Patient Pfizer population immunity postvaccination profile Protective protective immunity provided reduced regimen restored reveal robust SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection second dose Serum level serum levels serum samples significant increase significantly significantly higher specific antibody Spread status vaccination Vaccine vaccine dose vaccine platform [DOI] 10.1128/jvi.00177-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific CD4 + T cells are associated with long-term persistence of neutralizing antibodiesSARS-CoV-2-특이적 CD4 + T 세포는 중화 항체의 장기간 지속성과 관련이 있습니다Article Published on 2022-04-232022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] accompanied Alpha anti-N IgG anti-RBD antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta CD4 Cluster Clusters Critical CXCL10 CXCL9 CXCR3 decay declined Delta disease onset Frequency Gamma highlight Humoral immunity Immune escape Lambda Ligand maintenance neutralized Neutralizing antibodies neutralizing antibody Neutralizing-antibody omicron Omicron variant P.1 persistence PROTECT protective immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants Significant significantly lower T cell T cells T-cell understanding vaccination Vaccine variant [DOI] 10.1038/s41392-022-00978-0 PMC 바로가기 [Article Type] Article
Long-Term, CD4 + Memory T Cell Response to SARS-CoV-2SARS-CoV-2에 대한 장기 CD4 + 메모리 T 세포 반응Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Antibody titers Antigen caused CD4 Chinese Cohort composed convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease-19 Coronaviruses COVID-19 cross-reactive cross-reactivity demonstrated disease spread Endemic Factor global pandemic HCoV healthcare worker Humoral immunity immune response immune responses Immunity include individuals Infection long-term memory long-term memory. memory NL63 nucleocapsid nucleocapsid antigen OC43 onset of symptoms Prevent protective immunity recruited reported respiratory respond response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein study period T cell T cell immunity T cell memory T cell response T cells the spike protein Vaccine design Viral viral spread [DOI] 10.3389/fimmu.2022.800070 PMC 바로가기 [Article Type] Article
A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant재조합 소단위 백신은 SARS-CoV-2 P.1(감마) 변이체에 대한 원숭이에서 강력하고 광범위하게 중화되며 내구성 있는 항체 반응을 유도합니다Article Published on 2022-04-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anamnestic response Antigen B.1.351 B.1.617 Beta boost breadth cause circulating Concentration coronavirus CoVaccine HT cynomolgus macaques delayed challenge disease dose dosed effective Efficacy elevated evaluated Final Gamma Heterologous IgG Immunity immunization immunized immunogenic induce Infection information isolates liquid Lower respiratory tract Lung pathology lyophilized macaque macaques moderate moderate to severe mRNA natural infection Neutralizing antibodies neutralizing antibody Neutralizing antibody response P.1 pandemic potent Prevent Protective protective immunity Protein recombinant reduce Reinfection required respiratory response restored robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease significantly specific neutralizing antibodies subunit subunit protein vaccine Subunit vaccine the SARS-CoV-2 upper and lower respiratory tract Vaccine vaccine immunity variants of concern Viral Viral load viral loads VoC VOCs [DOI] 10.1021/acsinfecdis.1c00600 PMC 바로가기 [Article Type] Article