Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case ReportCase Report Published on 2021-06-302022-10-31 Journal: Children [Category] COVID-19, [키워드] Antiviral Antiviral treatment bloodstream Care Child children Continuous Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 DExH-BOX helicase 30 (DHX30) DHX30 Exome Extensive extracorporeal life support (ECLS) gastrointestinal symptoms gene encoding heart failure Helicase hyperinflammation Hypothyroidism immunomodulatory Impella Infection initiated invasive ventilation microcephaly multiple organ failure Mutation myocarditis patient’s death pediatric Prevent progression Pseudomonas aeruginosa report resulting RNA SARS-CoV-2 Sequencing severity starting Support the patient therapy Treatment vaccination viral clearance [DOI] 10.3390/children8070564 PMC 바로가기 [Article Type] Case Report
Rhamnolipids Nano-Micelles as a Potential Hand SanitizerArticle Published on 2021-06-222022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] active site adopted antibacterial agent antiviral agent antiviral treatments Bacteria caused characterized China Computational study COVID-19 demonstrated docking Docking studies hand Health hygiene in vitro Interaction investigated medium membrane permeability molecular multidrug resistant nano-micelles non-structural protein pandemic disease performed Perspective Potential problem produced Proteins Pseudomonas aeruginosa Rhamnolipid rhamnolipids SARS-CoV-2 selected shown silico study social distancing suggested the SARS-CoV-2 utility virus transmission [DOI] 10.3390/antibiotics10070751 PMC 바로가기 [Article Type] Article
Emergent Pneumonia in ChildrenPediatrics Published on 2021-06-172022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Acinetobacter Adults affecting Bacteria changed children circulation coronavirus COVID - 19 effective emerging respiratory pathogens Epidemiology form Influenza less Measures MERS-CoV Mycoplasma pneumoniae pathogen Pathogens Pneumonia pneumonia - clinical features and management Post-vaccine Prognosis Pseudomonas aeruginosa re-emerging respiratory pathogens recognize rhinovirus SARS-CoV-1 SARS-CoV-2 serotype therapy Tuberculosis virus [DOI] 10.3389/fped.2021.676296 PMC 바로가기 [Article Type] Pediatrics
Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial StrainsArticle Published on 2021-05-172022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] Acinetobacter activity addition antibacterial activity Antibiotics antimicrobial antimicrobial peptide antimicrobial peptides Bacteria Candida albican Cell toxicity chemical derivatives Cm-p5 Compound Concentration Corona demonstrated derivative dose-dependent manner Enterococcus faecium ESBL eukaryotic cell evaluated Extended Extracellular had no Herpe Infection inhibited Klebsiella pneumoniae microbial moderate monomer multiresistant microorganisms Mycobacterium tuberculosis pathogenic strain peptide Pseudomonas aeruginosa pseudoparticle respiratory SARS-CoV-2 Spectrum strain Streptococcus tested Toxicity virulent Zika ZIKV [DOI] 10.3390/biom11050745 PMC 바로가기 [Article Type] Article
Biocidal Resistance in Clinically Relevant Microbial Species: A Major Public Health RiskReview Published on 2021-05-142022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Acinetobacter Active surveillance antimicrobial antimicrobial resistance approach Biocidal biocide COVID-19 pandemic demonstrated disease transmission Disinfection effective emerging disease Enterobacter Enterococcus faecium Environment ESKAPE example fungal Health Infectious disease information Klebsiella pneumoniae lack Major measure microbial multidrug-resistant one health pathogen Pathogens patient mortality proliferation PROTECT Pseudomonas aeruginosa Public public health reduce resistance risk Staphylococcus aureus Treatment WHO [DOI] 10.3390/pathogens10050598 PMC 바로가기 [Article Type] Review
Regulation and Function of ILC3s in Pulmonary InfectionsImmunology Published on 2021-04-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Bacterial cause clearance COVID-19 cytokine demonstrated evaluate exacerbated function group IL-17 IL-22 ILC3, innate lymphoid cell (ILC) immune mechanism Immunity immunological function incidence Infection Inflammation innate immune cell innate lymphoid cell intestine Lower lung Lung infection microbial morbidity and mortality mucosal Pneumonia promote Pseudomonas aeruginosa pulmonary pulmonary infections Regulation respiratory infection respond SARS-CoV-2 secrete stimulated Streptococcus pneumoniae tissue tissue homeostasis tissue repair [DOI] 10.3389/fimmu.2021.672523 PMC 바로가기 [Article Type] Immunology
Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture FindingsArticle Published on 2021-04-202022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Acinetobacter acute respiratory syndrome antimicrobial consumption antimicrobial expenditure assisted ventilation Bacteria BAL Blood Bronchoalveolar lavage Candida parapsilosis clinical Co-infection collected condition coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 negative COVID-19 patient Critically ill patient drug Enterococcus faecium favor finding Frequency fungi highest Hospitalized ICU ICUs Ill impairment Infection infectious risk intensive care intensive care unit Intervention invasive Isolation less microbial microbial culture microorganisms Non-COVID-19 outcome Patient Pseudomonas aeruginosa required respiratory specimen respiratory tract SARS-CoV-2 severity shown Urine Ventilation [DOI] 10.3390/ijerph18084358 PMC 바로가기 [Article Type] Article
Risk Factors for Mortality in Adult COVID-19 Patients Who Develop Bloodstream Infections Mostly Caused by Antimicrobial-Resistant Organisms: Analysis at a Large Teaching Hospital in ItalyArticle Published on 2021-04-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI age Analysis antimicrobial resistance Antimicrobial therapy association Blood bloodstream bloodstream infection BSI Candida clinically conducted COVID-19 COVID-19 patient Cox regression Culture death develop died discharge Enterococcus Factor help hospital Hospital admission in-hospital mortality inclusion criteria Infection isolates Italy Kaplan–Meier Mortality multidrug-resistant occurred organism Organisms outcome Patient patients patients with COVID-19 performed Pseudomonas aeruginosa reduce retrospective risk factor Risk factors SARS-COV-2 infection Septic shock Staphylococcus aureus survival survived Teaching variable were infected while [DOI] 10.3390/jcm10081752 PMC 바로가기 [Article Type] Article
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa : Implications for Current Resistance-Breaking Therapies녹농균(Pseudomonas aeruginosa)의 항생제 내성 빌딩 블록: 현재 내성 파괴 요법에 대한 시사점Review Published on 2021-04-162022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] accelerate acquired resistance adaptive addition adjuvant adjuvant therapies adjuvant therapy antibiotic Antibiotic treatment Antibiotics antimicrobial antimicrobial resistance (AMR) Antimicrobials arsenal bacterial cell Bacterial infection block blocks building causative agent contributing to COVID-19 pandemic current cystic fibrosis described drug effectors fibrosis focus genetic disease handling Hospitalized Host immune Infectious disease Infectious diseases Innovation lead lung Lungs majority MDR morbidity morbidity and mortality multidrug resistant multidrug-resistance (MDR) multidrug-resistant nosocomial P. aeruginosa pathogen Pathogens penetration predicted Prolonged Pseudomonas aeruginosa recent reduce resistance resistance mechanism resistance mechanism interplay resistance mechanisms resistance-breaking therapy SARS-CoV2 infection secondary bacterial infection selective selective pressure selective pressures Spread Strains target targets therapeutic agents therapy Threats widespread World Health Organisation [DOI] 10.3389/fcimb.2021.665759 PMC 바로가기 [Article Type] Review
Persistent Bacterial Coinfection of a COVID-19 Patient Caused by a Genetically Adapted Pseudomonas aeruginosa Chronic Colonizer유전적으로 적응된 녹농균(Pseudomonas aeruginosa) 만성 집락자에 의한 COVID-19 환자의 지속적인 세균 동시 감염Cellular and Infection Microbiology Published on 2021-03-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adapted adenine alginate Analysis Antibiotic resistance Bacteria biofilm cause chronic chronic infection chronic infections Coinfection collected component COVID-19 COVID-19 patient COVID-19 patients demonstrated differential gene expression analysis displaying DNA DNA methylation ENhance Epigenetic Exacerbation Extracellular matrix flagellar Gene expression analysis Genes genomic high mortality rate hospital Immunocompromised Immunocompromised patient Immunocompromised patients in vivo indicated isolate leads marker Methylation morphology opportunistic pathogen overproducing P. aeruginosa pathogen Patient performed persistent phenotypic predicted Pseudomonas aeruginosa quorum reducing SARS-CoV-2 Sequencing severe COVID-19 transcriptional regulation transcriptomic variant virulence [DOI] 10.3389/fcimb.2021.641920 PMC 바로가기 [Article Type] Cellular and Infection Microbiology