pyroptosis – Page 8 – Communicable Diseases Research

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases

Article

Published on 2021-11-012022-10-04
Journal: Acta pharmacologica Sinica [Category] SARS, 신약개발,

[키워드] activating activity addition alcohol anti-inflammatory activity applied cause caused Cellular responses circulating Colitis Complication contribute disulfiram DSF dysregulated immune response effective Efficacy endotoxin gasdermin D glycoprotein immunosuppressive Infection Inflammation Inflammatory cytokine inflammatory disease inflammatory disorders Inflammatory response inhibitor lactoferrin life-threatening ligands Macrophage macrophage-targeting delivery macrophages multifunctional murine Neutralizing offer organ dysfunction patients pyroptosis Safe Sepsis therapeutic therapeutic effect therapeutic strategy treat Treatment ulcerative colitis various inflammatory disease
[DOI] 10.1038/s41401-021-00770-w PMC 바로가기 [Article Type] Article

Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages

Article

Published on 2021-10-152022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

시겔라 유비퀴틴 리가제 IpaH7.8은 가스더민 D를 분해 대상으로 삼아 파이로ptosis를 방지하고 감염을 가능하게 한다.

Article

Published on 2021-10-132024-08-22
Journal: Cell Host & Microbe [Category] 세균성이질,

[키워드] GSDMD Inflammasome proteasome pyroptosis Shigella ubiquitin ligase virulence

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Article

Published on 2021-10-042022-10-04
Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제,

Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia

article

Published on 2021-09-302024-09-01
Journal: Clinical and Experimental Immunology [Category] 폐렴구균 감염증,

[키워드] Co-infection IL-4 Influenza pyroptosis Streptococcus pneumoniae
[Article Type] article

Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies

SARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법

Review

Published on 2021-09-212022-09-01
Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin
[DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review

Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

Interleukin-1RA는 인간화 된 K18-HASE-2 마우스에서 SARS-COV-2- 유도 된 염증성 폐 혈관 누출 및 사망률을 완화시킨다.

10008

Published on 2021-09-092022-09-10
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] Fulltext, MERS, SARS, 바이오마커,

[키워드] activated activation of inflammasome acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Anakinra blockade cadherin caspase characterized content coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Digital Digital Content domain downregulation edema Endothelial cell endothelial cells human lung humanized Hyperinflammatory ies IL-1 IL-1 receptor antagonist IL-1ra immune response immunomodulatory therapy Infection Inflammasome Inflammatory Injury innate immune interleukin-1 junction junctions leakage lung lung edema lung endothelial Lungs mechanism mice morbidity morbidity and mortality NLR NLRP3 Prevent prevented Protein provide pyroptosis receptor receptor antagonist receptor signaling respiratory respiratory distress Respiratory distress syndrome Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling significantly increased survival susceptible syndrome text Treatment Vascular Vascular injury vascular system injur VE-cadherin
[DOI] 10.1161/ATVBAHA.121.316925 PMC 바로가기 [Article Type] 10008

P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia

P2X7 수용체 길항제 BBG는 세포 내 스트레스와 피로프토시스를 억제하여 대상포진 후 신경통을 완화합니다.

Article

Published on 2021-09-012023-05-31
Journal: Molecular and cellular biochemistry [Category] 대상포진, 두창, 수두, 홍역,

[키워드] endoplasmic reticulum stress P2X7 receptor Postherpetic neuralgia pyroptosis
[DOI] 10.1007/s11010-021-04169-3

P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia

Article

Published on 2021-09-012023-05-31
Journal: Molecular and cellular biochemistry [Category] 두창, 수두, 홍역,

[키워드] endoplasmic reticulum stress P2X7 receptor Postherpetic neuralgia pyroptosis
[DOI] 10.1007/s11010-021-04169-3

Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape

Review

Published on 2021-08-112022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] ACEi Activation alteration Angiotensin converting enzyme inhibitors angiotensin II receptor blockers ANGPTL3 ARB Atherosclerosis Biomarker can be used cardiovascular disease Cardiovascular disorders cellular changes circulating Clinical practice Complication continuum Coronary heart disease coronavirus disease COVID-19 Diabetic drug dysfunction Efficacy endothelial Endothelial dysfunction endothelial function Endothelium enzyme evaluate event heart failure hypertension hypertensive patients implication inhibitor Injury Intervention landscape molecular Mortality Myocardial infarction Notch novel obese predict Prevent Prognostic factor progression pyroptosis respond severity Signaling statin subject the disease therapy thrombus formation vascular disorders viral infection
[DOI] 10.3390/biomedicines9080997 PMC 바로가기 [Article Type] Review