reduced risk – Page 8 – Communicable Diseases Research

CONVALESCENT plasma for COVID-19: A meta-analysis of clinical trials and real-world evidence

COVID-19에 대한 CONVALESCENT 혈장: 임상 시험 및 실제 증거에 대한 메타 분석

Meta-Analysis

Published on 2021-11-012022-09-11
Journal: European Journal of Clinical Investigation [Category] SARS, 임상,

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

C5178a 및 A249d/T6392C/G10310A의 일반적인 mtDNA 변이는 중국 중부의 한족 인구에서 심각한 COVID-19의 위험을 감소시킵니다

Research

Published on 2021-11-012022-09-10
Journal: Military Medical Research [Category] Fulltext, MERS, 변종, 진단,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis association calculate cardiopulmonary diseases categorical variables chest X-ray China CIs common Computed tomography conducted confounding factor continuous variables contribute Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytochrome C cytochrome c oxidase D-loop decrease determine diabetes diagnosed diagnostics disease distribution DNA exclusion criteria Fisher’s exact test Han Chinese healthy control healthy controls hypertension increased risk independent Infection investigated Logistic regression Logistic regression analyses Mitochondria mitochondrial mitochondrial DNA molecular molecular diagnostics MtDNA variations multivariate multivariate logistic regression NADH ND1 ND2 ND3 obesity Odds ratio Odds ratios oxidative phosphorylation oxygen performed Phylogenetic analysis qPCR radiographic examinations reactive oxygen specy reduced risk respiratory Result risk SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus severe COVID-19 Sex shown smoking Student’s t -test subunit supplementary material the healthy variables variant variants Variation Viral viral genome vital role vital roles was used with COVID-19
[DOI] 10.1186/s40779-021-00351-2 PMC 바로가기 [Article Type] Research

Development of a predictive prognostic rule for early assessment of COVID-19 patients in primary care settings

Research article

Published on 2021-11-012022-10-05
Journal: Atencion Primaria [Category] SARS, 유전자 메커니즘,

[키워드] analyses cardiac disease clinical Clinical course Comorbidities Comorbidity Confusion correlation Course COVID-19 COVID-19 patient Critical Deceased demographics development diabete Dyspnoea evaluated external validation Follow-up headache hospitalised hypertension increased risk increasing age laboratory-confirmed Logistic regression Male sex men Mortality myalgia myalgias objective Older outcome participant Patient patients Predictive Predictive model primary care Prognosis prognostic Prognostic factor reduced risk relationship remained renal Result retrospective cohort risk ROC setting significantly Spain survivor Symptom symptomatic patient Symptoms variables
[DOI] 10.1016/j.aprim.2021.102118 [Article Type] Research article

Whey-Derived Peptides at the Heart of the COVID-19 Pandemic

COVID-19 팬데믹의 중심에 있는 유청 유래 펩타이드

Article

Published on 2021-10-282022-09-10
Journal: International Journal of Molecular Sciences [Category] 치료제,

[키워드] ACE ACE inhibitor ACE inhibitors ACE inhibitory activity ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association blood pressure blood pressure homeostasis Captopril cells component coronavirus COVID-19 COVID-19 pandemic drugs dual enzyme exhibiting heart human ACE2 hypertension inhibit inhibitory inhibitory action inhibitory activity IPP Lisinopril molecular docking molecular interaction peptide peptide sequences peptides Previous studies produced RAS RAS inhibitor RAS inhibitors receptor reduced risk renin–angiotensin system renin–angiotensin system reported respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus shown synthetic drugs therapeutic Treatment treatment of COVID-19 were assessed whey peptides
[DOI] 10.3390/ijms222111662 PMC 바로가기 [Article Type] Article

Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study

Observational Study

Published on 2021-10-282022-10-04
Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, 임상,

Education Attainment, Intelligence and COVID-19: A Mendelian Randomization Study

Article

Published on 2021-10-222022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition

GSK-3 억제를 통한 코로나바이러스 뉴클레오캡시드 단백질 표적화

Multicenter Study

Published on 2021-10-192022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, 치료법,

[키워드] acute respiratory syndrome Analysis Antiviral approach Betacoronavirus block Clinical data conducted consensus sequence consensus sequences conserved coronavirus Coronavirus infection Coronavirus infections Coronaviruses COVID-19 COVID-19 in patient COVID19 Epidemics epithelial cells Express glycogen glycogen synthase GSK-3 GSK3A GSK3B health system Healthcare systems human lung human lung epithelial cells impair inhibitor inhibitors knockout less lithium lithium use lung epithelial cell Middle East Middle East respiratory syndrome Middle East respiratory syndrome-CoV motif N protein nucleocapsid nucleocapsid protein Odds ratio Outbreaks Patient personal health phosphorylated Phosphorylation raising reduced risk Replication required respiratory responsible Retrospective analysis SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N protein Severe acute respiratory syndrome Significance significantly targeting the SARS-CoV-2 therapy Transcription treat Viral viral replication viral transcription virion assembly
[DOI] 10.1073/pnas.2113401118 PMC 바로가기 [Article Type] Multicenter Study

Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021

2020년 7월-2021년 5월 헌혈을 기반으로 한 미국 감염 및 백신 유도 SARS-CoV-2 혈청 유병률 추정

Article

Published on 2021-10-122022-09-11
Journal: JAMA [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] 95% CI adjust age antibodies black Blood blood collection blood donation Blood donations blood donor Blood donors Combined conducted COVID-19 case cross-sectional cross-sectional study cumulative defined detectable donor sample estimate Estimated Ethnicity Final General population Hispanic incidence rates Infection median National nucleocapsid occurred Older organization organized outcome Prevalence proportion reduced risk regions repeated reported representing SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence SARS-CoV-2 spike selected Seroprevalence specimen subsequent tested vaccination Vaccine Washington Weighting women
[DOI] 10.1001/jama.2021.15161 PMC 바로가기 [Article Type] Article

Effect of Pre-exposure Use of Amantadine on COVID-19 Infection: A Hospital-Based Cohort Study in Patients With Parkinson’s Disease or Multiple Sclerosis

Neurology

Published on 2021-10-072022-11-01
Journal: Frontiers in Neurology [Category] COVID-19,

Risk factors associated with severe hospital burden of COVID-19 disease in Regione Lombardia: a cohort study

Observational Study

Published on 2021-10-072022-10-04
Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상,

[키워드] Admission age appear approach association being Characteristics cohort study contributed COVID-19 COVID-19 disease Critical care death decrease discharge event example Factor Final First wave healthcare healthcare worker hospital hospital management Hospital-fatality risk hypothesised ICU ICU admission improvement increased risk Infection Italy knowledge Length lockdown Lombardia mixture model Mortality mortality risk Multi-state model Non-survivors Observational cohort study Odds ratio outcome pathway Patient PCR-confirmed performed progression Protective public health reduced risk Regression Result risk risk factor supplementary material Surveillance Survivors Treatment understanding
[DOI] 10.1186/s12879-021-06750-z PMC 바로가기 [Article Type] Observational Study