Repurposed drug – Page 8 – Communicable Diseases Research

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

햄스터 모델에서 SARS-CoV-2에 대한 Favipiravir 항바이러스 효능

Article

Published on 2021-03-192022-09-10
Journal: Nature Communications [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

Chemistry

Published on 2021-03-122022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

Modeling of SARS-CoV-2 Treatment Effects for Informed Drug Repurposing

Pharmacology

Published on 2021-03-102022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

가교 펩타이드 및 용도 변경 약물은 SARS-CoV-2의 두 진입 경로를 모두 억제합니다

Article

Published on 2021-03-092022-08-31
Journal: Nature Communications [Category] SARS, 신약개발, 치료제,

[키워드] Antiviral approach Arbidol camostat cells Chloroquine cocktail Combination coronavirus Coronaviruses COVID-19 COVID-19 treatment Cross-linking drug combination Drug discovery effective Endocytic pathway Endosomal acidification ENhance entry pathway hamster hamsters identify in vitro in vivo inhibit inhibit SARS-CoV-2 inhibiting inhibitor mice pathway peptide Repurposed drug Repurposed drugs SARS-CoV SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress suppresse therapy TMPRSS2 TMPRSS2 inhibitor today treating COVID-19 Treatment treatment trial treatment trials umifenovir Viral viral replication virus entry
[DOI] 10.1038/s41467-021-21825-w PMC 바로가기 [Article Type] Article

An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?

Pharmacology

Published on 2021-03-082022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] affecting Against Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antibiotics antiviral drugs antivirals approach approved drug Candidates Chloroquine Clinical efficacy Clinical findings clinical study clinical trial clinically Complete conducted Convalescent plasma therapy Corticosteroid COVID-19 COVID-19 pandemic COVID-19 patients drug Drug repurposing Drug-drug interactions drugs effective Effectiveness evaluate Favipiravir Hydroxychloroquine identify International limitation Long-term follow-up Lopinavir-ritonavir Lung inflammation mechanism mechanism of action Open-label oseltamivir pharmacokinetics Placebo Population Randomized randomized clinical trial recorded reduce regimens regions Registered Remdesivir Repurposed drug Research ribavirin SARS-CoV-2 Spread therapeutic Till treat Treatment Trial umifenovir virus were used WHO
[DOI] 10.3389/fphar.2021.632677 PMC 바로가기 [Article Type] Pharmacology

Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional Study

Protocol

Published on 2021-03-042022-10-29
Journal: JMIR Research Protocols [Category] COVID-19,

[키워드] “COVID-19 African alleles amplification analyses Analysis Apoptosis apoptotic pathways association Bax BCL-2 BCL2L12 Biomarker carried caspase 3 categories caused CD4 collected Comorbidity complete blood count Concentration country COVID-19 COVID-19 complication COVID-19 pandemic cross-sectional Cytokine storm determinant determine Disease progression distribution DNA EDTA ELISA enrolled enzyme-linked immunosorbent expected expression expression level flow cytometry Frequency genetic determinants Genomic DNA genotyped genotypes genotypic genotyping Haplotype Hardy-Weinberg equilibrium Health health system help Hospitalized hospitalized patient Hypovitaminosis D Identifier Immunopathogenesis IMPROVE Improving include individual infected patients infected with SARS-CoV-2 information Lagos Linkage disequilibrium Lymphocyte count lymphopenia MONITOR Nigeria objective Other outcome participant Participants Patient PCR performed phenotypic polymerase chain polymorphism Prevalence Prognosis questionnaire R statistical software report Repurposed drug Result reverse transcribed reverse transcription PCR risk stratification RNA RNA sample RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–positive Sequencing serum sample serum vitamin D severe infections soluble Fas ligand Stratification study outcome T cell assay T lymphocyte Total Travel Treatment treatment regimen understanding vascular cell adhesion VDR venous blood Vitamin D receptor Vitamin D status with COVID-19
[DOI] 10.2196/21242 PMC 바로가기 [Article Type] Protocol

Neutralizing monoclonal antibodies for COVID-19 treatment and prevention

COVID-19 치료 및 예방을 위한 단일클론항체 중화

Review

Published on 2021-03-012022-09-12
Journal: Biomedical journal [Category] SARS, 신약개발, 진단, 치료법,

Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted

Molecular Biosciences

Published on 2021-02-182022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome Adverse adverse event Affect angiotensin-converting enzyme 2 anti-retroviral drug Antibiotics bind Central nervous system Chloroquine clinically CNS Combination Complication concurrence consequence contributing to coronavirus Corticosteroid COVID - 19 COVID-19 Critical Dexamethasone Diseases dissemination Drug interactions drug-drug interaction Encephalitis Encephalopathy event Evidence Favipiravir Guillain-barrè syndrome help hematogenous Hemorrhagic highlight human cell Hydroxychloroquine Hypogeusia Hyposmia immune responses include induce Injury leukoencephalopathy Lopinavir-ritonavir mechanism mechanisms medication Meningitis morbidity and mortality nervous system neurologic neurologic manifestations Neurological disorder neurological manifestation neuronal Neuropsychiatric neuropsychiatric adverse effects neurotropic neurotropism off-label outcome pandemic pathophysiological Pathways Perspective Pneumonia Post-infection potential therapy Psychiatric disorders psychological Impact receptor Remdesivir Repurposed drug researchers Respiratory complications SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection stroke syndrome therapeutic potential thrombosis Tocilizumab Uncharted venous virus virus infection with COVID-19
[DOI] 10.3389/fmolb.2021.627723 PMC 바로가기 [Article Type] Molecular Biosciences

Carvacrol, a Plant Metabolite Targeting Viral Protease (M pro ) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19

Plant Science

Published on 2021-02-162022-10-31
Journal: Frontiers in Plant Science [Category] COVID-19,

Molecular Mechanism of Action of Repurposed Drugs and Traditional Chinese Medicine Used for the Treatment of Patients Infected With COVID-19: A Systematic Scoping Review

Pharmacology

Published on 2021-02-122022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,