Correlation between Clinical and Wastewater SARS-CoV-2 Genomic Surveillance, Oregon, USAArticle Published on 2022-09-012022-11-16 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome clinical coronavirus coronavirus disease correlation correlation coefficient COVID-19 Effectiveness estimate Evidence genomic genomic sequencing Genomic surveillance Oregon proportion respiratory infections SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 specimen Surveillance United States USA variant viruses wastewater wastewater surveillance Wastewater-based epidemiology zoonoses [DOI] 10.3201/eid2809.220938 PMC 바로가기
Household Secondary Transmission of the Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant From a Community Cluster in a Nursery in Japan중증급성호흡기증후군 코로나바이러스 2 알파 변종 일본 보육원 커뮤니티 클러스터에서 가구 이차 전파Article Published on 2022-09-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults Alpha variant analyzed children Cluster coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 exhibited greater high risk household household SAR increase in Increased investigated Japan nursery patients Previous studies reported respiratory SARS SARS-CoV-2 secondary secondary attack rate secondary transmission severe acute respiratory syndrome Coronavirus spread to Transmissibility Transmission transmission route Transmission routes variants variants of concern virus VoC VOCs were infected whole-genome sequencing [DOI] 10.1097/INF.0000000000003607 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 태반 감염은 모체-태아 경계면에서 대규모 Perivillous 섬유소 침착과 관련이 있습니다: 예비 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha variant Chain Reaction coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 deposition FIBRIN fibrin deposition Frequency immunohistochemistry massive pandemic Placenta polymerase chain polymerase chain reaction respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus [DOI] 10.1093/cid/ciac173 PMC 바로가기 [Article Type] Article
Real-World Effectiveness of Remdesivir in Adults Hospitalized With Coronavirus Disease 2019 (COVID-19): A Retrospective, Multicenter Comparative Effectiveness Study코로나바이러스 질병 2019(COVID-19)로 입원한 성인에서 렘데시비르의 실제 효과: 후향적, 다기관 비교 효과 연구Multicenter Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] 19 2 28-day mortality 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted hazard ratio Clinical improvement Comparative Control controls coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patients death Diagnosis dose Effectiveness healthcare Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients ICD-10 individual less likelihood low-flow oxygen male median age Mortality oxygen Patient patients Positive test Primary outcome real recipient Remdesivir retrospective routine SARS SARS-CoV-2 secondary outcome severe acute respiratory syndrome Coronavirus severely ill patient significantly significantly more Support symptomatic the United State Therapeutics Treatment United States unlikely world effectiveness. [DOI] 10.1093/cid/ciab1035 PMC 바로가기 [Article Type] Multicenter Study
Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 델타 변종 AY.127의 동물 간 전파 가능성이 있어 홍콩에서 애완동물 가게 관련 코로나바이러스 질병 2019(COVID-19) 발생Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 2 acute respiratory syndrome acute respiratory syndrome coronavirus Analysis anti-SARS-CoV-2 antibody causing Chain Reaction collected conducted Contact coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 outbreak Delta delta variant Delta variant AY.127 demonstrated direct contact dwarf enzyme enzyme immunoassay euthanized female Genome genomes Genomic analysis hamster hamsters Hong Kong Human husband immunoassay infect International investigation Laboratory mammals Mesocricetus nucleotide outbreak pandemic virus Patient patients performed pet Phodopus polymerase chain polymerase chain reaction positive Randomly reported respiratory reverse transcription reverse transcription polymerase chain reaction route RT-PCR SARS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Sequencing analysis seropositive severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen Spread strain susceptible tested Transmission transmission of SARS-CoV-2 transmitted whole genome Whole genome sequencing [DOI] 10.1093/cid/ciac171 PMC 바로가기 [Article Type] Article
Neutralizing Antibody Response to Pseudotype Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Differs Between mRNA-1273 and BNT162b2 Coronavirus Disease 2019 (COVID-19) Vaccines and by History of SARS-CoV-2 Infection유사형 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 중화 항체 반응은 mRNA-1273과 BNT162b2 코로나바이러스 질병 2019(COVID-19) 백신과 SARS-CoV-2 감염의 역사에 따라 다릅니다.Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 19 2 95% confidence interval Antibody titer BNT162b2 BNT162b2 vaccine calculated coronavirus 2 CoV COVID COVID-19 Dilution dose geometric mean GMT GMTs highest history increase Infection inhibitory linear mixed-effects models mRNA mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 mRNA-1273 vaccine NAb Neutralizing antibodies neutralizing antibody participant participants with SARS-CoV-2 prospective cohort pseudotype virus receiving respiratory response SARS SARS-CoV-2 SARS-COV-2 infection sera single dose Symptoms T Test tested uninfected participant uninfected participants vaccination Vaccine vaccine dose was collected [DOI] 10.1093/cid/ciab1038 PMC 바로가기 [Article Type] Article
The Impact of Prior Infection and Age on Antibody Persistence After Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine중증 급성 호흡기 증후군 코로나바이러스 2 메신저 RNA 백신 후 항체 지속성에 대한 이전 감염 및 연령의 영향Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 19 2 acute respiratory syndrome affected age Antibody Response booster coronavirus coronavirus 2 CoV COVID Critical Determining environmental factor Genetic Immunity immunization Impact magnitude messenger Messenger RNA persistence respiratory RNA SARS SARS-CoV-2 SARS-COV-2 infection the antibody response the SARS-CoV-2 the timing vaccination Vaccine [DOI] 10.1093/cid/ciab850 PMC 바로가기 [Article Type] Article
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count현재 CD4 T-림프구 수를 기반으로 항레트로바이러스 치료를 받고 있는 인간 면역결핍 바이러스에 감염된 사람들의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 mRNA 백신 접종으로 유도된 체액 및 세포 면역 반응Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 2 vaccine Against AIDS anti ART BNT162b2 booster dose CD4 CD4 T-cell cell-mediated immune comparable confounders control group controls coronavirus 2 count CoV current detectable elicited HCDR HCW HCWs healthcare worker HIV HIV-negative Human IFN-γ immune response immunogenicity magnitude mRNA mRNA-1273 NAb NAbs Neutralizing Neutralizing antibodies parameter parameters participant PLWH predicted RBD-binding antibody RBD-binding IgG receiving reduced respiratory response SARS SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly significantly lower stratified T-lymphocyte titre were measured were used [DOI] 10.1093/cid/ciac238 PMC 바로가기 [Article Type] Article
Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein스파이크 단백질의 융합 전 상태를 표적으로 하는 신규 SARS-CoV-2 진입 억제제로서의 3-O-β-chacotriosyl ursolic acid 유도체의 식별, 최적화 및 생물학적 평가Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral activity Antiviral agents Cavity COVID-19 pandemic Delta derivative effective generate identification Infection inhibitor inhibitors membrane fusion Mutation offer omicron Pentacyclic triterpenoid saponins prefusion pseudotyped SARS-CoV-2 public health S protein S1 and S2 saponins SARS SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 variant Spike protein subunit the S protein the SARS-CoV-2 Vaccine variant variants Vero-E6 cell Vero-E6 cells virus-cell membrane fusion [DOI] 10.1016/j.ejmech.2022.114426 PMC 바로가기 [Article Type] Article