Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transportersArticle Published on 2010-07-032023-06-15 Journal: Pharmacology & therapeutics [Category] MERS, [키워드] ACE, angiotensin-converting enzyme ACE2 acute respiratory distress syndrome amino acid transporter Ang, angiotensin ARDS, acute respiratory distress syndrome AT1R, Angiotensin II receptor type 1 AT2R, Angiotensin II receptor type 2 Collectrin HNF-1, Hepatocyte nuclear factor-1 MODY5, Maturity onset diabetes of the young RAS, renin–angiotensin system renin–angiotensin system SARS SARS-CoV, severe acute respiratory syndrome coronavirus SARS, Severe acute respiratory syndrome [DOI] 10.1016/j.pharmthera.2010.06.003 PMC 바로가기 [Article Type] Article
Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a modelArticle Published on 2008-12-052022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] airway amplification amplify antibody approach approaches Cell culture cell line clinical samples coronavirus CPE, cytopathic effect Culture culture supernatant cultures Cytopathic effect described detect determine different time point epithelial evaluated experiment HAE HAE culture HAE, human airway epithelium HCoV-NL63 HCoV-NL63, human coronavirus NL63 Human identify Infection lack molecular NL63 nucleic acid pathogen Pathogens Propagation reagent reported respiratory pathogen respiratory viral respiratory virus SARS-CoV, severe acute respiratory syndrome coronavirus secretion sequence Sequence analysis TEM TEM, transmission electron microscopy Transcriptome transmission electron microscopy variety virus Whole transcriptome amplification WTA, whole transcriptome amplification [DOI] 10.1016/j.jviromet.2008.10.022 PMC 바로가기 [Article Type] Article
Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2Article Published on 2008-06-102022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] ACE2 ACE2, angiotensin converting enzyme 2 acute respiratory syndrome Angiotensin converting enzyme 2 (ACE2) binding cells coronavirus demonstrated endocytosis enzyme expressed flow cytometry fusion protein HEK293 cells human IgG1 implication mapped N-glycan N-linked glycosylation Protein purified RBD RBD-Fc RBD, receptor-binding domain receptor Receptor-binding domain (RBD) SARS-CoV SARS-CoV spike protein SARS-CoV, severe acute respiratory syndrome coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) Spike protein susceptible susceptible cell the RBD the receptor-binding domain the S protein Vaccine viral spike virus receptor [DOI] 10.1016/j.virusres.2008.03.004 PMC 바로가기 [Article Type] Article