Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico EvidencesOriginal Article Published on 2020-06-172022-10-30 Journal: Natural Products and Bioprospecting [Category] COVID-19, [키워드] 2019-nCoV anti-viral activity Antiviral antiviral activity Candidates caused Compound coronavirus disease COVID-19 Covid-19 main protease docking docking study druggability evidenced exhibiting globe glycyrrhizin Herbal remedies hesperetin Host in silico molecular docking natural nCOV-2019 outcome overcome plant Potential product protease receptor Recognition reported SARS-CoV SARS-CoV-2 scientist selected The 2019-nCoV Treatment [DOI] 10.1007/s13659-020-00253-1 PMC 바로가기 [Article Type] Original Article
SARS-Cov2 Clinical Diagnostics: Academic Scientists Take on the COVID-19 PandemicArticle Published on 2020-06-062022-10-05 Journal: Med (New York, N.Y.) [Category] SARS, 진단, [키워드] clinical COVID-19 diagnostic hospital Regulatory SARS-CoV-2 testing scientist [DOI] 10.1016/j.medj.2020.06.002 [Article Type] Article
COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatmentsReview Article Published on 2020-05-152022-10-30 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] COVID-19, MERS, SARS, [키워드] ACE2 angiotensin receptor antagonists angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors benefit blocker blockers changes in coronavirus SARS-CoV-2 Course COVID-19 COVID-19 disease COVID-19 pandemic deaths dose drug effective entry receptor Evidence exacerbate Fever Hypothesis kidney damage lowest Non-steroidal anti-inflammatory agents non-steroidal anti-inflammatory drug novel coronavirus disease NSAID NSAIDS opposite Pain pandemic Patient press Protective RAS renin-angiotensin system Safe SARS-CoV-2 scientist Side effect Spread switching therapy treat Treatment upregulating [DOI] 10.1007/s00210-020-01890-6 PMC 바로가기 [Article Type] Review Article
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitorsReport Published on 2020-04-242022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] 3CL pro administration cause caused complex coronavirus coronavirus disease COVID-19 crystal structure drug target drugs ENhance enzyme exhibit functional health emergency inhibitor lung M pro Novel coronavirus pandemic pharmacokinetic plasma polyprotein protease Protein provide pyridone reveal SARS-CoV-2 SARS-CoV-2 main protease scientist targeting the SARS-CoV-2 translated unliganded Viral proteins Viral RNA virus X-ray structure [DOI] 10.1126/science.abb3405 PMC 바로가기 [Article Type] Report
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2Research Article Published on 2020-03-272022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2-RBD amino acid transporter angiotensin-converting enzyme 2 AT1 bind binding cellular receptor chaperones complex coronavirus coronavirus disease COVID-19 domain enzyme Epidemic extracellular peptidase domain full-length human ACE2 heterodimers human ACE2 human cell in viral Infection insight interact Interaction Local membrane protein Microscopy molecular basis Neutral New coronavirus pandemic disease COVID-19 polar RBD receptor Receptor binding domain residues S protein SARS-CoV SARS-CoV-2 Science scientist spike glycoprotein Structure Trimeric spike protein [DOI] 10.1126/science.abb2762 PMC 바로가기 [Article Type] Research Article
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labelingResearch Article Published on 2019-01-112022-10-31 Journal: eLife [Category] Coronavirus, MERS, [키워드] assist Biotin breadth build caused Cell common cold Complete complex complexes comprehensive analysis Contact Coronaviral coronavirus Coronaviruses Critical cytoplasm demonstrated Determination disease enzyme Factor Factors genetic code help Host host cell host cells host protein host proteins Human infect Infection infections Interaction involved kill knowledge membrane MERS microenvironment Mild molecular mouse nose and throat Other Pathways platform positive-sense RNA virus Protein proximal proximity labeling question replicase complex replication complex researcher RNA virus RTC scientist severe disease short-lived starting point Symptom target therapeutic intervention These viruses translation translation initiation Transport turn Vesicular Transport Viral proteins viral RNA synthesis virus virus infection virus particles Virus-host interaction waste disposal [DOI] 10.7554/eLife.42037 PMC 바로가기 [Article Type] Research Article