sequencing data – Page 8 – Communicable Diseases Research

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

게놈 전반에 걸친 생물정보학 분석으로 SARS-CoV-2 발병의 주요 숙주 및 바이러스 요인 예측

Article

Published on 2021-05-172022-09-10
Journal: Communications Biology [Category] SARS, 변종, 유전자 메커니즘, 치료제,

Use of Genomics to Track Coronavirus Disease Outbreaks, New Zealand

뉴질랜드, 코로나바이러스 질병 발병을 추적하기 위한 유전체학 사용

Research

Published on 2021-05-012022-09-10
Journal: Emerging Infectious Diseases [Category] SARS, 유전자 메커니즘,

Expression profiles revealed potential kidney injury caused by SARS-CoV-2: a systematic analysis of ACE2 and clinical lessons learned from this discovery

발현 프로필은 SARS-CoV-2로 인한 잠재적인 신장 손상을 나타냈습니다: ACE2의 체계적인 분석 및 이 발견에서 얻은 임상 교훈

Research Paper

Published on 2021-04-302022-09-10
Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 ACE2 distribution ACE2 expression ACE2-positive cell ACE2-positive cells acute renal failure Admission Adults Analysis analyzed assessment assessments Blood urea nitrogen cause caused Cell city Clinical findings collected Collecting duct Comorbidities conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 positive patient creatinine Data analysis dataset EGFR elevated epithelial cells estimated glomerular filtration rate Evidence female filtration rate functions glomerular glomerular filtration rate healthy individuals hospital induce Infection infection site kidney kidney damage Kidney function Kidney injury kidney tissue Laboratory laboratory findings males nitrogen novel Novel coronavirus novel coronavirus disease organ organs pathophysiology Patient patients Pneumonia positive cells profile renal failure renal function reported retrospective RNAseq RNAseq data SARS-CoV-2 scRNA-seq data selected sequencing data serum creatinine single-cell Single-cell RNA sequencing systematic analysis the patient the SARS-CoV-2 Transcriptome transcriptome analysis urea urea nitrogen viral loads Wuhan Wuhan, China
[DOI] 10.18632/aging.202224 PMC 바로가기 [Article Type] Research Paper

SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray
[DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

대 기도 상피에서 COVID-19 관련 유전자의 발현에 영향을 미치는 유전 적 및 비 유전 적 요인

Multicenter Study

Published on 2021-04-212022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 binding ACE2 expression ACE2 gene active smoking affecting airway airway epithelium analyzed association Asthma Bronchial epithelium cardiovascular disease cause change chronic obstructive chronic obstructive pulmonary disease clinically Cohort cohorts contribute COPD COVID-19 COVID-19 severity COVID-19 susceptibility Defense determine disease course driven by enrichment analysis environmental factor epithelial eQTL eQTL mapping Evidence expression expression pattern expression patterns Factor Factors Gene Expression Gene Set Enrichment Analyses Genetic genetic factors Genetic variant Genetic variation Host host response hypertension identify immune response implicated individuals Inflammation inter-individual interferon investigated involved isoform non-binding obesity obstructive pulmonary disease performed phenotypic provide pulmonary disease Quantitative Regulation Regulatory replicated respiratory respiratory infections respiratory viruses Result risk factor RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data smoker Smokers smoking subsequent supplementary material suppressed susceptibility the SARS-CoV-2 virus These data uninfected Variability variant variants Variation viruses
[DOI] 10.1186/s13073-021-00866-2 PMC 바로가기 [Article Type] Multicenter Study

Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection

인간의 신장과 방광에서 안지오텐신 전환 효소 II 발현의 단일 세포 분석은 2019년 신종 코로나바이러스 감염의 잠재적 경로를 보여줍니다

Article

Published on 2021-04-202022-09-11
Journal: Chinese medical journal [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection ACE2 ACE2 expression ACE2 gene Acute kidney injury acute respiratory syndrome addition Analysis angiotensin Angiotensin-converting enzyme bioinformatics bladder Cell cell type cells co-expression coronavirus disease Coronavirus disease 2019 datasets detectable enzyme II epithelial cells evaluate Evidence evidence of expression Fever healthy house human kidney in urine independent Infection intermediate cell kidney kidney damage nCoV Novel coronavirus p value p values Patient Pearson correlation Pearson correlation coefficient provided proximal proximal convoluted tubule proximal tubule recent findings receptor Respiratory complications reveal SAME AS sequencing data Severe acute respiratory syndrome single-cell analysis Single-cell RNA sequencing subtype urinary system Urine virus
[DOI] 10.1097/CM9.0000000000001439 PMC 바로가기 [Article Type] Article

Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019

2019년 코로나바이러스 질병의 면역대사 재배선 및 면역병인에 대한 단일 세포 RNA 시퀀싱 분석

Immunology

Published on 2021-04-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] antibody secretion ATP13A3 ATP6V1B2 biological processe CD14 Cell cell population cell survival change contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Degradation differentiation elevated exacerbated expressed feature Glycolysis hyperinflammation Immune cell immune cells immune dysfunction Inflammation inhibit investigated involved KMT2E LDHA lead lysine mechanism memory B cell memory B cells metabolic changes mild patients mono monocyte Monocytes mononuclear cell mononuclear cells NSD1 Pathways Patient PBMCs Peripheral blood Peripheral blood mononuclear cells PGD PKM Plasma cell Plasma cells plasmablast plasmablasts progression promoted reduced RNA sequencing data SETD2 severe COVID-19 severe disease Severe patient severe patients signaling pathways Single-cell RNA sequencing survival TKT Transcription
[DOI] 10.3389/fimmu.2021.651656 PMC 바로가기 [Article Type] Immunology

Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data

Method

Published on 2021-04-012022-10-31
Journal: Genome research [Category] COVID-19, SARS,

Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 Pathologies

COVID-19 병리의 알코올 증강의 기본 메커니즘에 대한 네트워크 메타 분석

Meta-Analysis

Published on 2021-04-012022-08-31
Journal: Alcoholism, clinical and experimental research [Category] MERS, meta-analysis, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alcohol alcohol consumption Analysis anti-inflammatory mediator anti-inflammatory mediators augmentation base bioRxiv caused cellular metabolism changes in clinician conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokines dataset early phase Effect ENhance Ethanol EtOH Fever fibrosis Gene Expression gene expression profile GEO GEO database glucocorticoid Glucocorticoid receptor hepatic fibrosis HMGB1 homeostasis hyperinflammatory phase IL-1 IL-1β IL-6 IL-6 signaling pathways Inflammation Inflammatory mediators Ingenuity Pathway Analysis Ingenuity Pathway Analysis. inhibiting IPA JUN knowledge base lung mapped mediators Meta-analysis metabolism molecule molecules network Network meta-analysis Neuroinflammation pandemic Pathologies pathway Pathways Patient predicted receptor respiratory retrieved risk RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins sequencing data severe acute respiratory syndrome Coronavirus signaling pathway STAT systemic inflammation TNF transcription factors Viral viral infections worldwide crisis
[DOI] 10.1111/acer.14573 PMC 바로가기 [Article Type] Meta-Analysis

Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs

Article

Published on 2021-03-302022-10-04
Journal: Cell Discovery [Category] 진단,