Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn [DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic InterventionPharmacology Published on 2020-07-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 Alpha alveolar cell antagonists Apoptosis AT1 biological marker blockade blockers capillary leakage CDK9 Cell cellular and molecular chemotactic clinical feature clinical marker contribute COVID-19 COVID-19 immune response CRP cytokine release Cytokine storm Cytokines cytoplasmic Defense Degradation Dexamethasone differentiation Diffuse alveolar damage downstream signaling pathway doxycycline element elevated elevated lactate dehydrogenase entry of SARS-CoV-2 epithelial estrogen receptor expression IL-17 IL-6 immune immune response Immunity include infiltration Inflammatory Inflammatory cytokine inflammatory cytokine production inflammatory signaling inhibitor initial Injury interferon response Intervention Ivermectin Jak kinase inhibitors LDH lung tissue MAPK mechanism melatonin membrane fusion membrane-bound molecular monocyte monocyte-derived macrophage NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil-to-lymphocyte ratio NF-κB NLR p65 pathogenic pathophysiology pathway Platelet Pneumocytes Point Potential pro-inflammatory promote Prophylaxis provoke receptor reduce Remdesivir Research respiratory epithelia respiratory epithelial cells SARS-CoV-2 coronavirus selective Signal transduction skewed subtype T-cell therapeutic interventions therapeutic response Therapeutics thrombosis TNF-α type I interferons type III Vascular Viral load virus [DOI] 10.3389/fphar.2020.01169 PMC 바로가기 [Article Type] Pharmacology
Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the StormImmunology Published on 2020-06-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” activate acute respiratory syndrome affected Anti-inflammatory approach approved cause caused characterized China Cholinergic anti-inflammatory pathway clinically COVID- 19 COVID-19 CRS Cytokine Release Syndrom (CRS) Cytokine release syndrome effort epidemiological Evidence Hospitalized hyperinflammation Hypothesis Inflammation inhibit less lung many cases New coronavirus Nicotine pathway patients pro-inflammatory cytokine Proinflammatory cytokine receptor reduce Release rising mortality Safe SARS-CoV-2 SARS-CoV-2 (virus) severe SARS-CoV-2 Signal transduction smoker statistically storm Therapies therapy Treatment ulcerative colitis worldwide pandemic [DOI] 10.3389/fimmu.2020.01359 PMC 바로가기 [Article Type] Immunology
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica포스포릴레이 BarA/SirA는 Salmonella enterica에서 비동족 조절기 RcsB를 활성화합니다.Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated activating addition Alter Bacteria bacterium binding site Cell cell envelope cell wall changes in condition Control detect domain environmental stress expressed Gene Expression Genes growth help Infection life logarithmic growth Luria-Bertani medium modify organism Organisms outer membrane perturbations promote Protein Proteins RcsB regulator Regulatory respond RNA Salmonella Signal transduction specificity Spectrum Stress Transcription [DOI] 10.1371/journal.pgen.1008722 PMC 바로가기 [Article Type] Research Article
Streptococcus pneumoniae hijacks host autophagy by deploying CbpC as a decoy for Atg14 depletion스트렙토코쿠스 뉴모니에가 CbpC를 Atg14 고갈을 위한 미끼로 배치하여 숙주 자가포식을 탈취한다.Article Published on 2020-04-022024-07-31 Journal: EMBO Reports [Category] 폐렴구균 감염증, [키워드] ATG14 autophagy Autophagy & Cell Death CbpC Microbiology, Virology & Host Pathogen Interaction p62 Signal transduction Streptococcus pneumoniae [DOI] 10.15252/embr.201949232 PMC 바로가기 [Article Type] Article
A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis VirusArticle Published on 2019-11-162022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accumulated addition alteration amino acid metabolism Analysis analyzed chicken correlation dataset examined expressed gene functions Gout Gut gut microbiota host response immune response Infection Infectious Bronchitis Virus kidney Kidney disease mechanism metabolic pathways metabolite metabolome metabolomic metabolomics microbial community Microbiome microbiomes nephropathogenic infectious bronchitis virus phenotype phenotypic profile progression provide purine Research resulting RNA-Seq Signal transduction torrelation analysis Transcriptome transcriptomic [DOI] 10.3390/v11111070 PMC 바로가기 [Article Type] Article
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation말라리아 기생충의 cGMP 의존성 단백질 키나제 구조는 활성화를 위한 독특한 구조적 중계 메커니즘을 드러낸다.Article Published on 2019-07-092024-08-11 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] cyclic GMP malaria Plasmodium Signal transduction Structure [DOI] 10.1073/pnas.1905558116 PMC 바로가기
UBXN1 interacts with the S1 protein of transmissible gastroenteritis coronavirus and plays a role in viral replicationResearch Article Published on 2019-04-272022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Antiviral binding cause cDNA library Cell cells clone coronavirus Degradation diarrhea downregulated expression expression level gastroenteritis glycoprotein GST host receptor identify IFN-β in viral indicated Infection inhibition interact intestinal cell intracellular protein involved late phase morbidity and mortality negative control overexpression positive Protein protein domain protein synthesis provided regulate Replication Research responsible Sequencing sialic acid Signal transduction signaling pathways significantly significantly increased siRNA TGEV the S1 protein UBXN1 viral titer yeast [DOI] 10.1186/s13567-019-0648-9 PMC 바로가기 [Article Type] Research Article
Differential Regulation of Type I and Type III Interferon SignalingReview Published on 2019-03-212023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] interferon interferon signaling Jak-STAT Signal transduction Type I IFN Type III IFN [DOI] 10.3390/ijms20061445 PMC 바로가기 [Article Type] Review
Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage InfectionArticle Published on 2019-03-192024-08-28 Journal: Cell Reports [Category] 말라리아, [키워드] hepatocyte Plasmodium, ribosomal protein S6 Signal transduction Toxoplasma