COVID-19, host response treatment, and the need for political leadershipArticle Published on 2020-12-022023-06-16 Journal: Journal of public health policy [Category] MERS, SARS, [키워드] ACE2 Angiotensin receptor blockers COVID-19 generic drugs host response statins [DOI] 10.1057/s41271-020-00266-7 PMC 바로가기
Pharmacogenomics for Primary Care: An OverviewReview Published on 2020-11-122024-09-02 Journal: Genes [Category] 대상포진, [키워드] Adverse drug reaction antidepressants clopidogrel drug hypersensitivity implementation pharmacogenomics primary care statins Warfarin [DOI] 10.3390/genes11111337 PMC 바로가기 [Article Type] Review
Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational ApproachOriginal Paper Published on 2020-11-102022-10-31 Journal: JMIR Medical Informatics [Category] COVID-19, [키워드] 2019-nCoV Analysis applicability applied approach association automated base clinical status Community computational method confidence score coronavirus coronavirus disease COVID-19 deep learning Dexamethasone disease Diseases drug drug side effects drugs effective effective drug Effectiveness effort entity Evidence Genes help highlight human genes human miRNAs Hydroxychloroquine IMPROVE information Interaction Ivermectin labeling lower mortality novel objective patients hospitalized pharmacological treatment platform Potential Preparing public health Remdesivir Research resources Result resulting SARS SARS-CoV-2 Scientific community similarity statin statins Therapeutic treatment Treatment Vaccine with COVID-19 [DOI] 10.2196/21648 PMC 바로가기 [Article Type] Original Paper
Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesisCOVID-19의 표현형을 결정하는 숙주-바이러스-약물 상호작용: 데이터 기반 가설Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] Coronavirus, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 affecting cardiovascular disease clinical phenotypes Comorbidities Comorbidity Compound compounds Corticosteroid Corticosteroids COVID-19 COVID-19 susceptibility data-driven determinant diabete diabetes drug interaction enrichment analysis Evidence gene set enrichment analysis gene signature gene signatures Host Hypothesis Infection inhibitors Interaction kinase inhibitors micronutrients NSAIDS overlapping phenotype Phenotypes SARS-CoV-2 severe COVID-19 statins synergism transcriptional Treatment tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Viral virus [DOI] 10.1016/j.mehy.2020.110275 PMC 바로가기 [Article Type] Article
Statins and SARS-CoV-2 disease: Current concepts and possible benefitsArticle Published on 2020-10-232023-06-16 Journal: Diabetes & metabolic syndrome [Category] MERS, [키워드] angiotensin-converting enzyme 2 cardiovascular disease Coronavirus disease 2019 myeloid differentiation factor 88 Nuclear factor kappa light chain enhancer of activated B cells SARS-CoV-2 statins Toll-like receptors [DOI] 10.1016/j.dsx.2020.10.021 PMC 바로가기 [Article Type] Article
The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link to InflammationCOVID-19의 깔끔한 춤: NEAT1, DANCR 및 공동 조절 콜린성 RNA가 염증과 연결Immunology Published on 2020-10-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Accompanying ACE2 Acetylcholine acetylcholine signaling age Analysis association bioinformatics Blood Blood cells Brain candidate Cell culture cellular Central nervous system changes in cholinergic cholinergic neurons coding transcript coding transcripts cognitive Cohort Complication Consequences COVID-19 COVID-19 infection COVID-19 pandemic Dance DANCR Decline decrease diagnostic diagnostics donors expression followed by H1N1 H1N1 influenza human lung identify increase increases in infected cell Infection Inflammation Inflammatory Influenza inter-individual involved long non-coding RNA lung lung cell lung cells lung tissue lung tissues manifestation medication men and women MicroRNAs miRNA ncRNA ncRNAs NEAT1 Neurological complications Neuron non-coding RNA nuclear parasympathetic Post-infection predicted profiles qRT-PCR Quantitative reflected risk RNA RNA-seq dataset RNA-sequencing SARS-CoV-2 selected shifting Signaling statins Supporting susceptibility TFS therapeutic tissue tissue-specific expression tissues transcript transcription factor transcription factors transcriptomic transcripts Variability viruses weakened with COVID-19 woman [DOI] 10.3389/fimmu.2020.590870 PMC 바로가기 [Article Type] Immunology
[Lipid treatment in the period COVID-19]Review Published on 2020-10-012023-07-06 Journal: Semergen [Category] SARS, [키워드] COVID-19 Estatinas Ezetimiba Ezetimibe Fármacos hipolipemiantes Hipercolesterolemia hypercholesterolemia Hypolipidemic drugs Inhibidores de PCSK9 PCSK9 inhibitors statins [DOI] 10.1016/j.semerg.2020.06.014 PMC 바로가기 [Article Type] Review
Statin Use Is Associated with Decreased Risk of Invasive Mechanical Ventilation in COVID-19 Patients: A Preliminary StudyArticle Published on 2020-09-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] adjusted Admission Affect age Analysis analyzed Anti-inflammatory association associations cardiovascular disease chronic pulmonary disease Comorbidity conducted confidence Course COVID-19 COVID-19 patient CVD Decreased demographics diabetes HMG-CoA HMG-CoA reductase inhibitors hospital Hospitalization hospitalized patients ICU immunomodulatory effects implication IMV In-hospital death inhibitor intensive care interval Invasive mechanical ventilation management Mechanical medication medications multivariate logistic regression obesity outcome past medical history Patient patients hospitalized performed pleiotropic Prospective Study Ratio retrospective cohort study Rhode Island risk SARS-CoV2 severe COVID-19 Sex significantly statin statins Support USA were recorded with COVID-19 [DOI] 10.3390/pathogens9090759 PMC 바로가기 [Article Type] Article
Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UKReview Article Published on 2020-09-152023-07-02 Journal: Atherosclerosis [Category] SARS, [키워드] Bile acid sequestrants COVID-19 Ezetimibe Fibrates hyperlipidaemia Lipid lowering therapy Lomitapide Omega-3-fatty acids PCSK9 monoclonal antibodies statins Volanesorsen [DOI] 10.1016/j.atherosclerosis.2020.09.008 PMC 바로가기 [Article Type] Review Article
Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic ComplicationsArticle Published on 2020-09-082022-10-30 Journal: Molecular neurobiology [Category] COVID-19, MERS, SARS, [키워드] activated addition Affect affecting Aminoacridine anti-inflammatory agents Anti-inflammatory drugs antimalarial Antimalarials Aortic body arachidonic acid blood vessels Brain endothelial cells carotid body Cell culture Central nervous system Chloroquine clinical trial CNS combating Complication coronavirus coronavirus disease Coronavirus replication COVID COVID-19 COX cPLA2 cross cytokine Cytokine storm cytosolic Cytosolic phospholipase A2 Dementia disorder DMT1 drug Effect Eicosanoids ENhance expression free radical Free radical damage free radical formation generate Glossopharyngeal nerve hippocampus Hydroxychloroquine Hypoxemia impair induce Inflammation Inflammatory response inhibit inhibiting inhibition inhibitor iron accumulation Iron transport isoform isoforms lung lysosomal enzymes lysosome Lysosomes mice Microcirculation microglia Microvessels Neuroinflammation Neurovascular Nucleus of the tractus solitarius organ oxidative damage oxidative stress PLA2G2D pro-inflammatory produced quinacrine reducing Respiratory centre resulting SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 virus Secretory phospholipase A2 Seizures severe cases shown silent sPLA2 IID statins stroke the SARS-CoV-2 virus tissue TNF-α Treatment unique vagus nerve Vascular vascular dementia viral replication [DOI] 10.1007/s12035-020-02093-z PMC 바로가기 [Article Type] Article