Dealing With Immunoglobulin Shortages: A Rationalization Plan From Evidence-Based and Data Collection면역글로불린 부족 처리: 증거 기반 및 데이터 수집의 합리화 계획Article Published on 2022-05-192022-09-12 Journal: Frontiers in Public Health [Category] MERS, 진단, [키워드] 95% CI addition analyzed Clinical management Clinical use close monitoring Collection coronavirus disease COVID-19 decrease demonstrated Effectiveness evaluate Evidence-based medicine Evolution IgG IgGs Immunoglobulin immunogolobulins indication information initial Intervention lack managing mean difference measure Measures occurred pandemic Patient performed plan public health public health system Rationalization real-world data Regional registry retrospective second shortages statistically Support the mean therapeutic Treatment was collected [DOI] 10.3389/fpubh.2022.893770 PMC 바로가기 [Article Type] Article
Dynamics of SARS-CoV-2 Alpha (B.1.1.7) variant spread: The wastewater surveillance approachSARS-CoV-2 Alpha(B.1.1.7) 변종 확산의 역학: 폐수 감시 접근 방식Article Published on 2022-05-152022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Alpha VOC Analysis analyzed Antibody binding approach average B.1.1.7 circulating circulation Combination Complete dominant Dynamics Epidemiology Europe explained herd immunity identify Immunity initial Mutation N gene NGS offer other variant other variants Outcompetition rate parameter plant qPCR real-time qPCR RT-qPCR S gene S glycoprotein S477N SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants spike glycoprotein Spread statistically Surveillance the SARS-CoV-2 Transmissibility Treatment United Kingdom variant variant of concern VoC was determined wastewater Wastewater-based epidemiology [DOI] 10.1016/j.envres.2022.112720 PMC 바로가기 [Article Type] Article
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect age alteration Alzheimer’s disease animal model baseline Biomarker Brain buffer change characterized comparable comparison detect determine develop dimension disease dysfunction early stage Effect facilitated Factor Fractal Genotype histopathological increase in indicated injected injection Interaction lack linear longitudinal majority mice neurodegenerative outcomes pathological change Pathologies pathology performed plaque quantified reduction returned statistically the disease wild-type [DOI] 10.1038/s41598-022-11582-1 [Article Type] Research
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer전립선암이 있는 남성의 COVID-19 질병에 대한 안드로겐 결핍 요법의 영향Multicenter Study Published on 2022-05-022022-09-11 Journal: JNCI Cancer Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval addition adjusted Affect Analysis androgen Androgen receptor androgens body mass body mass index Cell clinical disease cohorts Comorbidity COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 illness death defined demonstrated Deprivation epithelial cells evaluated Follow-up hazard ratio higher risk Hospitalization illness Impact Logistic lower risk mechanical ventilation median median age multicenter multicenter study multivariable Not demonstrated Older outcomes overall survival oxygen Oxygenation Patient patients performed Prostate cancer protease Regression model regulated respiratory epithelial cells retrospective cohort SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 disease severe COVID-19 illness significantly statistical test statistically suggested supplemental oxygen survival therapy TMPRSS2 Treatment upregulated within 6 months [DOI] 10.1093/jncics/pkac035 PMC 바로가기 [Article Type] Multicenter Study
Immune response to SARS-CoV-2 after a booster of mRNA-1273: an open-label phase 2 trialmRNA-1273 부스터 후 SARS-CoV-2에 대한 면역 반응: 공개 표지 2상 시험Clinical Trial Published on 2022-05-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse reactions anti-Spike IgG antibody Antibody titer Antibody titers B.1.617.2 booster booster dose booster injection Booster vaccine Breakthrough infection caused Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criterion delta variant disease dose Effectiveness elicited ELISA evaluated exploratory follow-up period Frequency immunized immunogenicity individual Infection injection Local memory B memory B cell Meso Scale Discovery mRNA mRNA-1273 MSD NAb NAb titers neutralizing antibody non-inferiority non-randomized Open-label participant Phase 2 phase 2 trial Phase 3 primary immunogenicity raised reported respiratory Safe SARS-CoV-2 second dose Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus significantly higher statistically systemic adverse reaction systemic adverse reactions titers vaccination Vaccine variants wild-type SARS-CoV-2 [DOI] 10.1038/s41591-022-01739-w PMC 바로가기 [Article Type] Clinical Trial
Boosting of serum neutralizing activity against the Omicron variant among recovered COVID-19 patients by BNT162b2 and CoronaVac vaccinesBNT162b2 및 CoronaVac 백신으로 회복된 COVID-19 환자 중 Omicron 변이체에 대한 혈청 중화 활성 증가Article Published on 2022-05-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis Antibody test Beta Beta variant BNT162b2 characteristic CoronaVac country COVID-19 Cutoff Delta delta variant detectable determine dose evade geometric geometric mean greater Immunity Inactivated vaccine individual induce Infection Live virus Michael mRNA vaccine NAb titer Neutralizing activity neutralizing antibody of BNT162b2 omicron Omicron variant prospective cohort study Protein receiver receiver operating characteristic Receptor binding recipient recovered COVID-19 patient Recovered COVID-19 patients Reinfection Richard risk SARS-CoV-2 Sensitivity and specificity seropositive serum Serum neutralizing antibody significantly higher spike Spike protein Spike protein receptor binding domain statistically subgroup analysis surrogate Surrogate neutralizing antibody test vaccination Vaccine variant variants virus with COVID-19 [DOI] 10.1016/j.ebiom.2022.103986 PMC 바로가기 [Article Type] Article
COVID-19 infections in infants Research Published on 2022-05-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] Asymptomatic children Clinical course Concentration cough COVID-19 COVID-19 infection COVID-19 testing D-dimer database diagnosed diagnosed with COVID-19 Diagnosis disorder elevated Fever First wave Gastrointestinal Gastrointestinal symptom Hospitalization Hospitalized IL-6 Infant Infants infected with SARS-CoV-2 Infection Mild MOST multicenter oxygen saturation Oxygen therapy pandemic Pneumonia Registered respiratory infection second wave selected serum significantly statistically Symptom the disease the patient Transmission with COVID-19 [DOI] 10.1038/s41598-022-11068-0 [Article Type] Research
Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) rapid test for SARS-CoV-2 neutralizing antibodiesSARS-CoV-2 중화 항체에 대한 정량적 측면 유동 면역 분석(LFIA) 기반 현장 진료(POC) 신속 검사 검증Article Published on 2022-05-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] analyzed antibody characteristic chemiluminescence immunoassay CLIA collected coronavirus coronavirus disease Coronavirus disease 2019 correlation correlation coefficient COVID-19 detect domain Effectiveness Efficacy evaluate evaluated Good Immunity Kruskal-Wallis test lateral flow immunoassay LFIA Mann-Whitney test Mindray NAbs Neutralizing antibodies no significant differences patients POC point-of-care Quantitative quantitative measurement Rapid test reading receiver operating characteristic respiratory respiratory syndrome coronavirus respiratory syndrome coronavirus 2 ROC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody sensitivity serological test severe respiratory syndrome significant differences Spike protein stability statistically the spike protein two group two groups Vaccine Vaccines validation widespread [DOI] 10.1007/s00705-022-05422-w PMC 바로가기 [Article Type] Article
Factors associated with psychological symptoms in hospital workers of a French hospital during the COVID-19 pandemic: Lessons from the first waveCOVID-19 대유행 기간 동안 프랑스 병원 병원 직원의 심리적 증상과 관련된 요인: 첫 번째 물결의 교훈Article Published on 2022-04-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] Anxiety Burnout checklist conducted COVID-19 COVID-19 pandemic COVID-19 patients cross-sectional survey Depression emotional Factor First wave French group HADS Health higher risk hospital Hospital staff infected patients Job satisfaction lesson Mental mental health mental health problems pandemic Paris participant Participants Patient Physicians Post-traumatic stress disorder preventive measure professionals promote protective factor psychological symptom psychological symptoms PTSD regression analysis reported SARS-CoV-2 Satisfaction scale Significant Specific statistically Symptom Symptoms these symptom these symptoms virus were infected with COVID-19 [DOI] 10.1371/journal.pone.0267032 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 Mutations on PCR Assay Sequence AlignmentSARS-CoV-2 돌연변이가 PCR 분석 시퀀스 정렬에 미치는 영향Article Published on 2022-04-282022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] alignment Analysis analyzed assays biosurveillance blind Chain Reaction clinical samples COVID-19 creating diagnosis of COVID-19 diagnostic diagnostics dominant Evidence evidence of failure False negative false negatives functional consequence functional consequences Genome genomic RNA growth highlight identify Impact in silico in viral molecular test Molecular tests Mutation mutations occurred pandemic PCR PCR assay PCR assays polymerase chain polymerase chain reaction preserved proportion Real-time monitoring Real-Time Reverse Transcription Polymerase Chain Reaction Region reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 sequences Sensitivity and specificity sequence sequence identity Sequencing signature statistically sustained therapeutic unique Vaccine variant Viral viral genomes whole genome whole genome sequence Whole genome sequencing [DOI] 10.3389/fpubh.2022.889973 PMC 바로가기 [Article Type] Article