synergy – Page 8 – Communicable Diseases Research

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

SARS-CoV-2에 대한 시너지 및 길항 약물 조합

Article

Published on 2021-02-032022-09-11
Journal: Molecular therapy : the journal of the American So [Category] SARS, 신약개발, 치료제,

Piloting an integrated SARS-CoV-2 testing and data system for outbreak containment among college students: A prospective cohort study

Research Article

Published on 2021-01-262022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

Israel’s rapid rollout of vaccinations for COVID-19

Integrative Article

Published on 2021-01-262022-10-30
Journal: Israel Journal of Health Policy Research [Category] COVID-19, MERS,

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

유전적 배경과 PfKelch13은 Plasmodium falciparum에서 PfCoronin 돌연변이의 artemisinin 감수성에 영향을 미칩니다

Research Article

Published on 2020-12-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect African Analysis Artemisinin Asia Biology can not clinical isolates combination therapies combination therapy continent develop domain drug pressure drug resistance Effect elevated Evidence evidence of Evolution focus Future Genetic genetic analysis genetic background genetic determinant genetic determinants Health in vitro independent isolate Laboratory malaria Mask mutant Mutation no evidence of parasite parasites pathway phenotype Plasmodium falciparum Protein reduced referred to representing selected selection pressure South America Spread standard treatment strain survival susceptibility synergy tested Transmission
[DOI] 10.1371/journal.pgen.1009266 PMC 바로가기 [Article Type] Research Article

In vitro synergy of isavuconazole in combination with colistin against Candida auris

Article

Published on 2020-12-082022-10-04
Journal: Scientific Reports [Category] 신약개발,

Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

TMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다

Research Article

Published on 2020-12-082022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry
[DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article

Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection

여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다

Review

Published on 2020-12-062022-09-12
Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 진단,

[키워드] α2-AP, α2-antiplasmin ACE2 ACE2, angiotensin-converting enzyme 2 activate addition Affect causative agent cause caused cell tropism circulating clinical observations Concentration contribute coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 infection COVID-19 pandemic death determine effective Exclusive or explain expression Factor HAI-1/SPINT1 heart host cells Infection infection rate information inhibitor inhibitors kidney kidney damage kidneys liver liver dysfunction Lungs MASPs, membrane-associated serine proteinases membrane fusion membrane-associated serine proteinases (MASPs) membrane-bound MERS, Middle East respiratory syndrome much higher myocardial injury Neurological complications organ other organ other organs PAI-1, plasminogen activator inhibitor 1 PCI, protein C inhibitor positive predominant proteinase QM/MD, quantum mechanical/molecular dynamics receptor relative SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS, Severe acute respiratory syndrome Sepsis Serine serine proteinase serpins significantly higher similarity spike (S) protein Spike protein SPINT1 SPINT2 structure–function relationship synergy term the disease the patient the SARS-CoV-2 thrombotic TMPRSS2 transmembrane transmission rate Treatment uPA, urokinase-type plasminogen activator Vaccine viral fusion viral spike protein viral spike proteins
[DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review

Identification and Tracking of Antiviral Drug Combinations

Article

Published on 2020-10-182022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

[키워드] A549 cells acute respiratory syndrome addition Antiviral antiviral drug antiviral drug combinations antivirals broad-spectrum antivirals calu-3 cells cells Combination convalescent serum coronavirus cycloheximide demonstrated developmental drug Efficacy EIDD-2801 epithelial HCV hepatitis C virus HIV-1 HIV-1 infection homoharringtonine Human immunodeficiency virus human lung identification identify in vitro Infection infections monensin monotherapy neutralizing antibody Prevent purified reduced Remdesivir resource SARS-CoV-2 synergistic synergy therapy Toxicity treat treatment for HIV viral strain virus
[DOI] 10.3390/v12101178 PMC 바로가기 [Article Type] Article

A Framework for Improving Policy Priorities in Managing COVID-19 Challenges in Developing Countries

Public Health

Published on 2020-10-142022-10-31
Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS,

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Article

Published on 2020-09-092022-10-31
Journal: Cell Host & Microbe [Category] COVID-19, Fulltext, SARS,

[키워드] Analysis angiotensin-converting enzyme 2 antibody bind binder binding block complex conformational change conserved coronavirus COVID-19 pandemic COVID-19 therapeutics CR3022 CR3022 epitope Cryo-electron microscopy cryo-EM cryogenic electron microscopy destruction disrupt epitope Fab facilitate host cell immune responses inaccessible inhibitors membrane fusion monoclonal antibody neutralization neutralize Neutralizing prefusion presentation RBD receptor Receptor binding domain recognize reveal SARS-CoV-2 spike Spike protein synergy the RBD the SARS-CoV-2 therapeutic therapeutic potential trimer trimeric spike Vaccine virus X-ray crystallography
[DOI] 10.1016/j.chom.2020.06.010 PMC 바로가기 [Article Type] Article