Increasing use of immunization information systems for routine vaccinations in independent community pharmacies: A randomized controlled trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Journal of the American Pharmacists Association : [Category] 임상, [키워드] analysis of variance baseline Community conducted Control control group coronavirus disease COVID-19 Critical enrolled Enrollment evaluate greater group groups immunization implementation Increasing independent information Intention Intervention involved knowledge offered outcome outcomes pandemic Pharmacy postintervention Randomized controlled trial recorded registry responsible Result significantly statistically significant difference System T Test technology took place vaccination were used [DOI] 10.1016/j.japh.2022.02.010 PMC 바로가기 [Article Type] Randomized Controlled Trial
Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System밀 배아 무세포 생산 시스템에 의해 합성된 스파이크 단백질의 이황화 결합 SARS-CoV-2 수용체 결합 도메인의 특성화 및 활용Article Published on 2022-07-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor Analysis bind cell-free protein synthesis characterization contribute COVID-19 COVID-19 therapeutics Disulfide disulfide bond Drug screening Endoplasmic reticulum evaluate Express functional Germ immunogenicity Interaction Mutation PDI Production Protein protein disulfide isomerase protein synthesis Rapid RBD RBD protein RBD-ACE2 SARS-CoV-2 SARS-CoV-2 SP spike Spike protein System translational utilization Vaccine viral infection Viral variants wheat [DOI] 10.3390/v14071461 PMC 바로가기 [Article Type] Article
Effect of Text Message Reminders and Vaccine Reservations on Adherence to a Health System COVID-19 Vaccination Policy: A Randomized Clinical TrialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: JAMA Network Open [Category] 임상, [키워드] 95% CI accelerate accelerated adherence adherent Adjusted analysis age analyzed Asian assigned black clinical conducted control group COVID-19 COVID-19 vaccination Effect evaluate follow-up period group health system Hispanic Intervention intervention group median message organization outcome pandemic participant Primary outcome Randomized randomized clinical trial Randomly receive reduced reminder representing reservation secondary significant increase significantly South System text vaccination Vaccine white women [DOI] 10.1001/jamanetworkopen.2022.22116 PMC 바로가기 [Article Type] Randomized Controlled Trial
Profound racial disparities in COVID-19 associated hospitalizations in rural Southwest GeorgiaResearch article Published on 2022-07-012022-10-05 Journal: The American journal of the medical sciences [Category] 바이오마커, [키워드] African American African Americans Americans Analysis Characteristics chi-square test Comorbidities coronavirus disease Course COVID-19 demographics dialysis discharged home duration of symptom examined Fever group groups hospital Hospitalization hospitalizations hypertension ICU care identify In-hospital males measure mechanical ventilation median age morbidity morbidity and mortality Mortality no difference obesity outcome Patient patients patients hospitalized performed presenting symptoms Prevalence public health Racial responsible Result retrospective cohort SAS significantly statistical analysis System t-test the United State variables version 9.4 was used Wilcoxon rank-sum test with COVID-19 [DOI] 10.1016/j.amjms.2021.10.013 [Article Type] Research article
COVID-19 outbreak trends in South Africa: A comparison of Omicron (B.1.1.529), Delta (B.1.617.2), and Beta (B.1.351) variants outbreak periods남아프리카 공화국의 COVID-19 발생 추세: 오미크론(B.1.1.529), 델타(B.1.617.2) 및 베타(B.1.351) 변종 발생 기간 비교Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, [키워드] addition average B.1.1.529 B.1.351 B.1.617.2 Bayesian information criterion Beta Beta (B.1.351) center correlation COVID-19 COVID-19 case COVID-19 cases COVID-19 outbreak data-driven database death Delta Delta (B.1.617.2) density ellipsoid Engineering fatality growth growth rate incidence Johns Hopkins Johns Hopkins University Joinpoint regression analysis less mortality rate omicron Omicron (B.1.1.529) Omicron variant outbreak Oxford peaked proportion provided Regression model reported Repository Safe Science significant increase significantly South South Africa System University of Oxford variant [DOI] 10.1016/j.jiph.2022.05.011 PMC 바로가기 [Article Type] Article
Comparability of clinical trials and spontaneous reporting data regarding COVID-19 vaccine safety Research Published on 2022-06-292022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] Adverse adverse event AEs anaphylaxis calculated clinical trial Cohort COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine trial first dose FIVE Follow-up highest inherent biase janssen limitation Local Moderna MONITOR myocarditis Pfizer Randomized controlled trial RCT RCTs reported Reporting risk second dose severe AE severe AEs shingle single dose Surveillance System systemic AE systemic AEs thrombosis Vaccine vaccine dose vaccine group Vaccines were assessed [DOI] 10.1038/s41598-022-13809-7 [Article Type] Research
Vitamin D Endocrine System and COVID-19: Treatment with Calcifediol비타민 D 내분비계와 코로나19: 칼시페디올로 치료Review Published on 2022-06-292022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 25OHD 25OHD deficiency 25OHD level 25OHD levels acute respiratory distress acute respiratory distress syndrome addition Admission angiotensin antimicrobial peptides Antiviral Antiviral agents approved ARDS association autophagy bradykinin calcifediol calcitriol Characteristics chemokine cholecalciferol coagulability complications Course Coverage COVID-19 COVID-19 pandemic Critical death described develop dose doses drug early stage early stages Effect effector mechanisms Endocrine endocrine system ENhance epithelial Evidence functional High dose Host hyperinflammatory phase ICU ICU admission include increased coagulability indication Infection integrity intensive care intensive care unit intervention study mechanical ventilation modulating mortality rate neutrophil Patient patients with SARS-CoV-2 pharmacokinetic pilot study prohormone prothrombotic public health systems RAAS reactive reduce Renin repositioning respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 significantly subsequent syndrome System the disease therapeutic options Treatment treatment of COVID-19 vaccination variant VDES viral evolution Vitamin Vitamin D vitamin D endocrine system vitamin D endocrine system. [DOI] 10.3390/nu14132716 PMC 바로가기 [Article Type] Review
The disruption of elective procedures due to COVID-19 in Brazil in 2020 Research Published on 2022-06-292022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] agency Brazil carried Course COVID-19 effort Elective Elective surgery full recovery Health hospital pandemic pandemic of COVID-19 performed reduction SUS System was used were used [DOI] 10.1038/s41598-022-13746-5 [Article Type] Research
Impaired Kallikrein-Kinin System in COVID-19 Patients’ SeverityObservational Study Published on 2022-06-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related [DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study
Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial남아프리카의 Sisonke 연구에서 의료 종사자를 대상으로 한 단회 용량 Ad26.COV2.S 백신의 안전성 평가: 3b상 시행 시험Clinical Trial Published on 2022-06-212022-09-12 Journal: PLoS Medicine [Category] MERS, 임상, 진단, [키워드] 48 hour Ad26.COV2.S vaccine adverse event AEs African age body ache breakthrough infections categories clinical clinical trials collected COVID-19 COVID-19 infection death demonstrated Effectiveness eligible evaluated expected Fever Final first vaccination Frequency HCW HCWs headache healthcare healthcare worker hospitalisations Immune system disorder implementation Implementation study IMPROVE incidence rate increasing age Infection injection site pain janssen men morbidity MOST National nervous system disorder occurred Open-label Pan participant Participants Phase 3 trials reactogenicity reactogenicity event Registered registry reported SAE SAEs safety evaluation safety profile serious AE single-arm design South South Africa Support Symptoms syndrome System thrombosis Trial triggered vaccination Vaccine [DOI] 10.1371/journal.pmed.1004024 PMC 바로가기 [Article Type] Clinical Trial