Immunogenicity of a vaccinia virus-based severe acute respiratory syndrome coronavirus 2 vaccine candidate백시니아 바이러스 기반 중증급성호흡기증후군 코로나바이러스 2 백신 후보의 면역원성Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody Response B.1.1.529 B.1.351 B.1.617.2 coronavirus COVID-19 COVID-19 pandemic develop Express immunogenicity inactivated mice mRNA Neutralizing activity recombinant spike proteins respiratory robust SARS-CoV-2 SARS-CoV-2 particles SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike proteins Support T-cell Response the SARS-CoV-2 Vaccine vaccine candidate vaccinia virus variants variants of concern vector Viral viral spike protein viral vectors VOCs was used Wuhan [DOI] 10.3389/fimmu.2022.911164 PMC 바로가기 [Article Type] Article
Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers미경험 및 회복기 의료 종사자를 대상으로 백신 접종 후 SARS-CoV-2에 대한 T 세포 반응을 평가하기 위한 두 가지 T 세포 분석 비교Comparative Study Published on 2022-07-222022-09-11 Journal: Clinical and experimental immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acquisition antibody Antibody responses AZD1222 Blood BNT162b ChAdOx1 ChAdOx1 nCoV-19 characterized complex convalescent correlated strongly correlation dose ELISPOT ELISpot assay evaluate HCWs healthcare worker implication Infection less magnitude measure membrane moderate naïve Nucleocapsid proteins Oxford Panel pathway patient population peptides Pfizer Pfizer/BioNTech processing proportion protocol Region reported Reporting representing Research response responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seasonal coronaviruses significantly lower Spike protein Spike-specific T-cell responses Standardization T cell T-cell T-cell assay T-cell Response T-cell responses vaccination Vaccine vaccinees virus [DOI] 10.1093/cei/uxac042 PMC 바로가기 [Article Type] Comparative Study
Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent IndividualsSARS-CoV-2 스파이크의 Omicron BA.1 돌연변이는 백신 접종 및 회복기 개인의 T-세포 반응 감소로 이어집니다Article Published on 2022-07-192022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alleles BNT162b2 BNT162b2 vaccine CD4 CD4+ T-cell CD4+ T-cell epitopes cellular immunity circulating cross-reactive cross-reactivity elicited Epitopes escape facilitated help HLA HLA class II HLA class II alleles HLA motif prediction immune Immune escape immunodominant epitope immunodominant epitopes individual infect loss of memory memory monitoring motif mRNA mRNA-based Mutation mutations natural infection Neutralizing antibodies omicron Omicron BA.1 variant predict predicted preserved reactivity response SARS-CoV-2 SARS-CoV-2 immunity selected spike Spike protein spike-protein strain T cell T cells T-cell T-cell epitope T-cell epitopes T-cell Response T-cell responses the spike protein vaccination variant virus variant virus variants [DOI] 10.3390/v14071570 PMC 바로가기 [Article Type] Article
Immunogenicity and Reactogenicity of Ad26.COV2.S in Korean Adults: A Prospective Cohort Study한국 성인에서 Ad26.COV2.S의 면역원성과 반응성: 전향적 코호트 연구Article Published on 2022-07-112022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S Adenovirus Adenovirus Vector Adverse adverse event adverse events AEs anti-S IgG Anti-spike baseline cellular immunity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Delta Dilution enrolled enzyme enzyme-linked immunospot assay evaluated fatigue Fever followed by geometric mean geometric mean titers GMT GMTs GRADE Humoral immunity IgG antibody immunogenic immunogenicity injection site pain interferon interferon-γ Korean mononuclear cell MOST myalgia NAb titer Neutralizing Neutralizing activity neutralizing antibody responses omicron Omicron variant Omicron variants outcome pandemic participant Peripheral blood Prospective prospective cohort study resolved respiratory Safe SARS-CoV-2 serious AEs severe acute respiratory syndrome Coronavirus Single-dose South Korea T-cell immunity T-cell Response T-cell responses the median U/mL university hospital vaccination Vaccines variant variants Viral Viral variants waning immunity wild-type WT SARS-CoV-2 [DOI] 10.3346/jkms.2022.37.e210 PMC 바로가기 [Article Type] Article
Response of COVID-19 vaccination in multiple sclerosis patients following disease-modifying therapies: A meta-analysis질병 조절 요법 후 다발성 경화증 환자에서 COVID-19 예방 접종의 반응: 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addressed anti-CD20 anti-CD20 therapy anti-CD20 treatment association benefit booster dose CD20 cellular response Cochrane Library conducted COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Disease-modifying therapies Efficacy evaluate foundation humoral Humoral response IFN-β immune response literature medRxiv Meta-analysis Multiple multiple sclerosis natural no significant difference Odds ratio Odds ratios other treatment other treatments Patient random-effect receiving receptor required response response to vaccination risk SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Science Serologic response serological Shanghai significantly higher sphingosine sphingosine-1-phosphate suggested supported T-cell Response therapy Treatment vaccination was performed [DOI] 10.1016/j.ebiom.2022.104102 PMC 바로가기 [Article Type] Meta-Analysis
The T-Cell Response to SARS-CoV-2 Vaccination in Inflammatory Bowel Disease is Augmented with Anti-TNF Therapy염증성 장 질환에서 SARS-CoV-2 백신 접종에 대한 T-세포 반응은 항-TNF 요법으로 증가Article Published on 2022-07-012022-09-12 Journal: Inflammatory bowel diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract antibody Antibody Response biologic bowel IBD IBD biologic therapy Inflammatory Inflammatory bowel disease response SARS-CoV-2 T-cell T-cell Response TCR TCR clonal vaccination [DOI] 10.1093/ibd/izac071 PMC 바로가기 [Article Type] Article
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T-세포 검출을 위한 T-세포 증식 분석Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] an area Analysis antibody approved AUC B-cell B-cell response blood sample Blood samples carried cellular cellular immune responses clinical setting clinical settings complex Control control group controls ELISA assay False positive False positives Health care Health care worker health care workers humoral Humoral and cellular immune responses IgG immune immune responses Immunoglobulin Immunoglobulin G Infection less lymphocyte lymphocyte transformation Lymphocyte transformation test majority membrane N and M non-infected nucleocapsid peptide peptide pool peptide pools proliferation Protein representing resulting ROC analysis S protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Stimulation T-cell T-cell Response T-cell responses the S protein the S1 subunit the SARS-CoV-2 thymidine Trigger vaccinated individual vaccination Vaccines were recorded [DOI] 10.1016/j.cca.2022.05.025 PMC 바로가기 [Article Type] Article
Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort studyObservational Study Published on 2022-07-012022-10-05 Journal: The Lancet. Healthy longevity [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] age antibody Antibody Response binding blood sample booster vaccination Care CD4 T-cell Cellular immune response cellular response Clinical outcome Comorbidity COVID-19 COVID-19 vaccination COVID-19 vaccine CXCL10 production Department EDTA eligible exclusion criteria Factors for inclusion frailty functional groups humoral IFN-γ IL-2 immune dysregulation immune protection immune response Impaired individual Infection IQR median median age neutralisation Observational cohort study Older participant Post-vaccine quantified response risk factor Sample SARS-CoV-2 SARS-COV-2 infection second vaccination SFU significantly staff stratified T-cell Response TNFα vaccination vaccine doses variant spike was reduced were assessed [DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
Humoral and cellular response to COVID-19 vaccination in patients with autoimmune inflammatory rheumatic diseases under real-life conditions실생활에서 자가면역 염증성 류마티스 질환 환자의 코로나19 예방접종에 대한 체액 및 세포 반응Observational Study Published on 2022-06-282022-09-12 Journal: Rheumatology (Oxford, England) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI anti-S antibody anti-S IgG approved Autoimmune cellular cellular response cellular T-cell response condition conducted COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine effective Efficacy evaluated highest humoral Humoral response IgG antibody Immunosuppression immunosuppressive Immunosuppressive medication Inflammatory inhibitors interferon-γ knowledge medication mRNA vaccination mRNA vaccine negative correlation non-responder Patient patients rheumatic disease Rheumatic diseases risk RTX SARS-CoV-2 spike protein significantly lower subgroup of patient T-cell T-cell Response the S1 subunit therapy TNF Tocilizumab vaccination vaccination efficacy vaccination responses Vaccine were measured [DOI] 10.1093/rheumatology/keac089 PMC 바로가기 [Article Type] Observational Study
Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between patients experiencing mild and severe symptoms모델링은 SARS-CoV-2 감염의 이질적인 결과를 요약하고 경증 및 중증 증상을 경험하는 환자 간의 타고난 면역 및 CD8 T 세포 반응의 차이를 정량화합니다.Article Published on 2022-06-272022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory distress applied Arm ARMS CD8 T-cell CD8 T-cell response CD8 T-cell responses clinical observations concert cure dataset death elicit empirical evidence entire spectrum estimate exhibiting feature heterogeneous heterogeneous outcome immune implication in viral indicated Infection innate immune innate immune response Intervention mathematical mathematical model Mild modeling Occurrence offered outcome outcomes parameter Patient provided Quantitative recrudescence respiratory distress SARS-CoV-2 SARS-COV-2 infection severe disease Severe infection severe symptom Symptom T-cell Response Variability Viral load Viral variants without symptom [DOI] 10.1371/journal.ppat.1010630 PMC 바로가기 [Article Type] Article