Probiotics: Versatile Bioactive Components in Promoting Human Health프리바이오틱스: 인간 건강 증진에 있어 다재다능한 생리활성 성분Review Published on 2020-08-272022-10-30 Journal: Medicina [Category] COVID-19, MERS, 세균성이질, [키워드] addressed administration approach Bacteria Care Clinical studies component COVID-19 Diagnosis disease drugs Effect Efficacy evidence based-medicine Factor Health Human intestinal flora lifestyle mechanisms nutrition positive probiotic properties Promoting provide regulatory agency Safety Side effect strain Strains Surveillance therapy this system Treatment yeast [DOI] 10.3390/medicina56090433 PMC 바로가기 [Article Type] Review
A combined deep CNN-LSTM network for the detection of novel coronavirus (COVID-19) using X-ray imagesResearch article Published on 2020-08-152022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료기술, [키워드] Accuracy assist AUC automated automatically chest X-ray CNN Combination Convolutional neural network coronavirus COVID-19 COVID-19 patient dataset death rate deep learning detection system diagnose Diagnosis diagnostic disease disease detection growth help Long short-term memory memory Novel coronavirus provide reduce sensitivity specificity Spread this system treat were used X-ray [DOI] 10.1016/j.imu.2020.100412 [Article Type] Research article
Impact of two-level filtering on emergency medical communication center triage during the COVID-19 pandemic: an uncontrolled before-after studyOriginal Research Published on 2020-08-142022-10-29 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] Coronavirus, MERS, [키워드] Accessibility adjusted Analysis analyzed average bystander condition conditions conducted confounding variables COVID-19 COVID-19 outbreak COVID-19 pandemic described disease Emergency medical communication center excluded highlighting identify Impact information Linear regression model maintaining Nantes University Hospital outbreak outcome measure potentially life-threatening Primary outcome Prospective Study Rapid reduce required resources Result significant increase significantly increased System this system transferred Triage [DOI] 10.1186/s13049-020-00775-0 PMC 바로가기 [Article Type] Original Research
Viral Evasion of the Complement System and Its Importance for Vaccines and TherapeuticsImmunology Published on 2020-07-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive Adaptive immune response Antiviral effect antivirals chemotaxis complement complement system COVID-19 pandemic dengue virus disease disease symptoms dysregulation Effective vaccines Effects ENhance evade exacerbate Extracellular Factor functions Genetic host response Immunity immunology Importance induce Inflammatory responses Innate immunity Interaction mechanism microorganisms neutralization Nipah virus occur outcome Pathogenesis Pathogens pathway PROTECT Regulation Research respond Stage System Therapeutics this system Vaccines viral infection viral infections viral infectivity Virology virus viruses West Nile Virus [DOI] 10.3389/fimmu.2020.01450 PMC 바로가기 [Article Type] Immunology
COVID–19-associated coagulopathy: An exploration of mechanismsReview Article Published on 2020-06-192022-10-28 Journal: Vascular Medicine (London, England) [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute respiratory distress anticoagulation antiplatelet characterized Clinical finding clinical trial clotting factors Coagulation Coagulopathy complement component contribute coronavirus disease COVID-19 Critical Critically ill patient D-dimer Degradation disease severity dissemination dysregulation effort Elevation endothelial injury global pandemic Hemostasis hypercoagulable Inflammation Inflammatory cytokines initiated innate immune system International Laboratory limit mechanism mechanisms microparticles Mortality MOST Neutrophil extracellular traps Neutrophils pathophysiology pathway Patient patients with COVID-19 Platelets predictor Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection syndrome this system thrombin thrombosis Vascular endothelium venous thromboembolism (VTE) viral infection Viral pneumonia virus [DOI] 10.1177/1358863X20932640 PMC 바로가기 [Article Type] Review Article
Hyperlocal Postcode Based Crowdsourced Surveillance Systems in the COVID-19 Pandemic ResponseCOVID-19 전염병 대응에서 하이퍼로컬 우편번호 기반 크라우드소싱 감시 시스템Public Health Published on 2020-06-092022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] Community COVID-19 crowdsource datasets Digital health disease effort facilitated globe Government granularity healthcare hotspot Hyperlocal identify incidence incidence of disease lifting Outbreaks pandemic Pandemic response Perspective platform post code map resource response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic saturated screening process Spread statistic Surveillance System this system [DOI] 10.3389/fpubh.2020.00286 PMC 바로가기 [Article Type] Public Health
Considerations for an Individual-Level Population Notification System for Pandemic Response: A Review and PrototypeViewpoint Published on 2020-06-052022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, [키워드] acute respiratory syndrome added advance benefit caused cellular China Community complementary Consequences coronavirus coronavirus disease country COVID-19 COVID-19 pandemic effective Epidemic Epidemics Extensive Government Health hygiene implementation Implementing include intensity Local lockdown measure media Mobile technology moderate New notification Notification system organized outbreak pandemic penetration physical distancing Population prototype public health authority real time required responses review severity Spread Surveillance System this system threat transmitted United Kingdom [DOI] 10.2196/19930 PMC 바로가기 [Article Type] Viewpoint
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
Manipulation of the Porcine Epidemic Diarrhea Virus Genome Using Targeted RNA RecombinationResearch Article Published on 2013-08-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Asian cause China deleted demonstrated diarrhea ENCODE epidemic diarrhea expression expression cassette functional Gene Genes genetics GFP Heterologous in vitro manipulation Modification ORF3 PEDV Protein Renilla luciferase Replication Research RNA RNA recombination structural protein the disease this system Vaccines viral genome virus Virus neutralization [DOI] 10.1371/journal.pone.0069997 PMC 바로가기 [Article Type] Research Article