633. Preliminary Results from a Phase 1 Single Ascending-Dose Study Assessing Safety, Serum Viral Neutralizing Antibody Titers (sVNA), and Pharmacokinetic (PK) Profile of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered adverse event AEs Ambrose ambulatory patient Assessing being binding BSN clinical development Cohort Concentration conserved consultant coronavirus COVID-19 COVID-19 mRNA vaccines Developed dose Ellie employee epitope Evidence Extended Fc region Frank geometric healthy human IgG1 hypersensitivity reaction Inc injection intramuscularly intravenously Ligand Mild Moderate COVID-19 monoclonal antibody neutralization pandemic participant phase Phase 1 PK modeling Placebo plaque reduction neutralization predicted prevention prevention of COVID-19 profile Randomized RBD Reactions reported Result Safety SARS-CoV-2 SARS-COV-2 infection SARS-like CoV serious AEs Serum neutralizing antibody single dose Support the receptor-binding domain the spike protein Therapeutics titer Tolerability translational Treatment Trial Variation were assessed were measured [DOI] 10.1093/ofid/ofab466.831 PMC 바로가기 [Article Type] Poster Abstracts
Titers of SARS CoV-2 antibodies in cord blood of neonates whose mothers contracted SARS CoV-2 (COVID-19) during pregnancy and in those whose mothers were vaccinated with mRNA to SARS CoV-2 during pregnancy산모가 임신 중 SARS CoV-2(COVID-19)에 감염되었거나 산모가 임신 중 SARS CoV-2에 대한 mRNA 예방접종을 받은 산모의 제대혈에서 SARS CoV-2 항체 역가Article Published on 2021-11-012022-09-11 Journal: Journal of perinatology : official journal of the [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody titer Blood Cord blood COVID-19 during pregnancy group immunity after vaccination infected with SARS-CoV-2 Infection mother mRNA Neonatal Neonate Neonates Pregnancy Protein Proteins SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 spike protein significantly higher Spike protein tested titer titers women [DOI] 10.1038/s41372-021-01216-1 PMC 바로가기 [Article Type] Article
Pfizer-BioNTech and Sinopharm: A Comparative Study on Post-Vaccination Antibody TitersArticle Published on 2021-10-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered administration antibody booster dose cardiovascular disease collected Comparative coronavirus disease COVID-19 COVID-19 vaccine Diseases doses Efficiency IgG IgG titer IgG titers Immunity immunosuppressive induce mechanisms Multivariable regression analysis participant Pfizer-BioNTech positive positively correlated prospective observational cohort Quantitative recipient recipients second dose Sinopharm specific antibody subject supported titer titers Vaccine Vaccines [DOI] 10.3390/vaccines9111223 PMC 바로가기 [Article Type] Article
Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 VaccinationBrief Report Published on 2021-10-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age antibodies antibody Antibody titer blood sample BNT162 vaccine BNT162b2 BNT162b2 vaccine collected decrease determine Efficacy and safety expected first vaccination Gender Health care worker help Month Neutralizing antibodies neutralizing antibody SARS-CoV-2 second vaccination significant decrease significantly titer vaccination Vaccinations vaccine immunogenicity were measured [DOI] 10.3390/vaccines9101145 PMC 바로가기 [Article Type] Brief Report
Cross-neutralization of SARS-CoV-2 B.1.1.7 and P.1 variants in vaccinated, convalescent and P.1 infected백신 접종, 회복기 및 P.1 감염자에서 SARS-CoV-2 B.1.1.7 및 P.1 변이체의 교차 중화Article Published on 2021-10-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 변종, 진단, [키워드] (alpha acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha antibodies antibody B.1.1.7 BNT162b2 BNT162b2 vaccine candidate Candidates cohorts convalescent coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Donor enrolled evaluate evaluated exit human sera Immunity less neutralization potency neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody P.1 P.1 variant pandemic Patient plasma Protective reduction respiratory SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-COV-2 infection SARS-CoV-2 strain serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly significantly lower strain tested the SARS-CoV-2 titer titers Vaccine variant variants of concern VOCs wild-type [DOI] 10.1016/j.jinf.2021.07.019 PMC 바로가기 [Article Type] Article
Performance of anti-SARS-CoV-2 antibody testing in asymptomatic or mild COVID-19 patients: A retrospective study in outbreak on a cruise ship무증상 또는 가벼운 CovID-19 환자에서 항 -SARS-COV-2 항체 검사의 성능 : 유람선 발병에 대한 후 향적 연구Research Article Published on 2021-09-282022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgM antibody Antibody responses Antibody testing Antibody titer Antibody titers Asymptomatic blood sample Blood samples collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient Cruise ship Diagnosis electrochemiluminescence immunoassay ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated false-negative Follow-up Genetic Genetic testing IgG antibodies IgG antibody IgM antibodies IgM antibody immunochromatographic assay initial lateral flow lateral flow immunochromatographic assay Mild mild COVID-19 patient mild COVID-19 patients nucleocapsid objective outbreak Patient performance positive result required respiratory responses Result Retrospective study Sample SARS-CoV-2 significantly lower specificity Spike protein Spike proteins the patient titer titers total antibodies total antibody used to evaluate was performed were measured [DOI] 10.1371/journal.pone.0257452 PMC 바로가기 [Article Type] Research Article
COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study수유 여성의 COVID-19 mRNA 백신 및 항체 반응 : 전향 적 코호트 연구Clinical Trial Published on 2021-09-172022-08-09 Journal: BMC Pregnancy and Childbirth [Category] SARS, 바이오마커, 임상, 진단, [키워드] antibodies in breastmilk antibodies transfer via breastmilk antibody antibody quantification Antibody Response antibody transfer association Blood BNT162b2 BNT162b2 Pfizer vaccine Breastfeeding breastmilk change clinical Clinical data clinical trial conducted convenience homogenous sample COVID-19 COVID-19 vaccination dominant dominant serum antibody response enrolled evidence of healthcare worker house human milk IgA IgG IgG antibodies IgM immunity after vaccination immunization immunological characteristics immunological profile in-house ELISA lactating lactating women lactation levels of antibody moderate mother mRNA vaccination mRNA vaccine positive post vaccination presence of antibody prospective cohort study quantified questionnaire Registered reported Result SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 trimeric spike protein serum antibody response shown Spike protein titer titers titers of IgG transfer Trimeric spike protein vaccination was performed women [DOI] 10.1186/s12884-021-04051-6 PMC 바로가기 [Article Type] Clinical Trial
Epidemiological study using IgM and IgG antibody titers against SARS-CoV-2 in The University of Tokyo, Japan (UT-CATS)일본 도쿄대학(UT-CATS)에서 SARS-CoV-2에 대한 IgM 및 IgG 항체 역가를 이용한 역학 연구Article Published on 2021-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected age antibody Antibody test antibody tests Antibody titer Antibody titers Asymptomatic blood sample chemiluminescent immunoassay Chemiluminescent immunoassay (CLIA) CLIA Clinical course Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutoff value determine Factors FIVE Gender health information healthy subject iFlash IgG IgG and IgM IgG antibody IgG antibody titers IgM IgM and IgG immunoassay infection with SARS-CoV-2 Japan median titer participant Participants positive positive rates qualitative detection questionnaire recruited required respiratory SARS-CoV-2 Seroepidemiological study serum serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) smoking status survey the patient titer Tokyo university Volunteer worldwide pandemic [DOI] 10.1016/j.jiac.2021.06.008 PMC 바로가기 [Article Type] Article
BNT162b2 SARS-CoV-2 Vaccination Elicits High Titers of Neutralizing Antibodies to Both B.1 and P.1 Variants in Previously Infected and Uninfected SubjectsBrief Report Published on 2021-08-292022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] B.1 B.1 variant baseline BNT162b2 Cohort correlated cross-neutralization Diagnosis driven by HCW Health care worker health care workers healthy highlighting infected individual Lineage live virus neutralization median Neutralizing antibodies Neutralizing antibody titer P.1 P.1 variant P.1 variants previously infected and uninfected subjects receiving SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant sera significantly significantly higher strain subject subjects tested titer uninfected vaccination vaccine dose variant [DOI] 10.3390/life11090896 PMC 바로가기 [Article Type] Brief Report
Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?타액의 Torquetenovirus : SARS-COV-2 감염을위한 잠재적 인 바이오 마커?Research Article Published on 2021-08-242022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] age amplification analyzed biological fluid biological fluids Biomarker both groups chronic infection chronic infections correlated COVID-19 diarrhea fatigue Fever Gender gene amplification group healthy individual healthy individuals Immune status individual likelihood Loss Loss of Smell marker mild respiratory symptoms nasopharynx negative controls positive positive individuals predict prevalent Prognosis provided remained resolved respiratory respiratory symptoms Saliva saliva samples SARS-CoV-2 SARS-CoV-2-positive individual SARS-CoV-2-positive individuals sore throat subject Symptom symptom duration symptom resolution the SARS-CoV-2 titer titers transplants was collected were assessed [DOI] 10.1371/journal.pone.0256357 PMC 바로가기 [Article Type] Research Article