An ethics framework for consolidating and prioritizing COVID-19 clinical trialsCOVID-19 임상 시험을 통합하고 우선 순위를 지정하기 위한 윤리 프레임워크Article Published on 2021-04-012022-09-11 Journal: Clinical Trials (London, England) [Category] SARS, 임상, [키워드] attribute Clinical research clinical trial clinical trials condition consolidation coronavirus COVID-19 COVID-19 research COVID-19 therapeutics criteria Critical determine effective intervention effective interventions Enrollment evaluated Guidance imperative institution Intervention offer prioritization raise recognizing Research Research Ethics resource resources respond robust Safe scarcity Support target tested threshold criteria Triage Trial trials upstream [DOI] 10.1177/1740774520988669 PMC 바로가기 [Article Type] Article
Subgenomic RNA identification in SARS-CoV-2 genomic sequencing dataMethod Published on 2021-04-012022-10-31 Journal: Genome research [Category] COVID-19, SARS, [키워드] 5′ UTR ACE2 Analysis applied arising canonical canonical sgRNA Cell cell lines changes in comprehensive analysis COVID-19 sample data set detect determine discontinuous transcription expected genomic RNA genomic sequence genomic sequencing homology identify in vitro leader sequence Local occur Open reading frame ORF ORF10 ORFs produced quantification replicate RNA RNA genome SARS-CoV-2 SARS-CoV-2 genome sequenced sequencing data sgRNA start codon the SARS-CoV-2 transcription regulatory sequence translation transmitted TRS-B TRS-L United Kingdom upstream variant [DOI] 10.1101/gr.268110.120 PMC 바로가기 [Article Type] Method
DNA methylation architecture of the ACE2 gene in nasal cells of childrenArticle Published on 2021-03-292022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 age black Cell children collected Contact contribute coronavirus 2 coronavirus disease COVID-19 COVID-19 severity CpG DNA methylation Epigenetic explain expressed female finding greater Hispanic influences influences on male males methylated nare nasal nasal epithelium nasal swab pandemic Participants Patient Prognostic markers receptors Regulation respiratory risk factor SARS-CoV-2 Sex tested upstream [DOI] 10.1038/s41598-021-86494-7 PMC 바로가기 [Article Type] Article
Editorial Perspective: Cabin fever – the impact of lockdown on children and young peopleEditorial Perspective Published on 2021-03-222022-10-31 Journal: Child and Adolescent Mental Health [Category] Coronavirus, SARS, [키워드] Antidote assist children complement debate Drawing editorial Evidence Fever Intervention Isolation lockdown mental health mental health services pandemic Psychological distress subject Support syndrome upstream [DOI] 10.1111/camh.12458 PMC 바로가기 [Article Type] Editorial Perspective
SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island lociSARS-CoV-2 핫스팟 돌연변이는 역 반복 및 CpG 섬 유전자좌 내에서 상당히 풍부합니다Case Study Published on 2021-03-212022-09-10 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] Analysis bioinformatics carried cause Coronaviridae family COVID-19 disease CpG CpG methylation creating decrease effort genomic hot spot humans inverted repeats investigated life cycle limit loci Mutation Nidovirale Nidovirales ORF predict progression SARS-CoV-2 SARS-CoV-2 genome sequenced significantly the disease the SARS-CoV-2 genome Transcription upstream Viral viral life cycle viral strain viral strains virus [DOI] 10.1093/bib/bbaa385 PMC 바로가기 [Article Type] Case Study
Relational solidarity and COVID-19: an ethical approach to disrupt the global health disparity pathwayResearch Articles Published on 2021-03-152022-10-31 Journal: Global Bioethics [Category] COVID-19, [키워드] Affect approach baseline Care clinical trials component country COVID-19 disease disparate disparity disrupt drugs Effect equity exacerbating facilitate global pandemic Health healthcare help International pandemic pathway Pragmatic reduce Region resource resources respond response social determinant social determinants of health solidarity susceptibility upstream while [DOI] 10.1080/11287462.2021.1898090 PMC 바로가기 [Article Type] Research Articles
Clinical, Serological, Whole Genome Sequence Analyses to Confirm SARS-CoV-2 Reinfection in Patients From Mumbai, IndiaMedicine Published on 2021-03-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence amino acid sequence analyses Analysis clades clinical collected Comparative COVID-19 criteria downstream duration of illness Evidence functional annotation Genome genome coverage genome variation genomic genomic variation IgG Immunity India individual information mandatory molecular Mumbai Neutralizing Non-synonymous nucleotide Oropharyngeal Patient patients Post-infection Prolonged infection Region Reinfection reported RNA RT-PCR tests S1 RBD SARS-CoV-2 SARS-COV-2 infection sequence Sequencing Seroconversion serological serology specific mutation supported sVNT symptomatic synonymous the SARS-CoV-2 genome upstream viral isolate virus was performed WGS while Whole blood whole genome Whole genome sequencing [DOI] 10.3389/fmed.2021.631769 PMC 바로가기 [Article Type] Medicine
Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon염증이 있는 IBD 조직에서 SARS-CoV-2의 장 수용체는 회장에서 HNF4A에 의해 하향 조절되고 결장에서 인터페론 조절 인자에 의해 상향 조절되는 것으로 보입니다Article Published on 2021-03-052022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression Alter analysed Analysis anti-TNF biopsy bowel Co-expression analysis collected Colon colonic Control COVID-19 Crohn's disease Cytokines Differential gene expression disease dysregulation entry mechanisms epithelial Factor HNF4A IBD IBD susceptibility gene ileal ileum Immunosuppressed inflamed CD ileum Inflammation Inflammatory Inflammatory bowel disease inflammatory bowel diseases inflammatory stimuli interferon intestinal intestinal inflammation intestine investigated Microarray Microarrays mucosal Necrosis network Organoid organoids Patient patients pro-inflammatory cytokine pro-inflammatory cytokines processed Prognosis regulated Regulating Regulation responders restored risk factor RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data shown significantly Single Cell single-cell therapy tissue TMPRSS2 transcriptomics ulcerative colitis upregulated upstream [DOI] 10.1093/ecco-jcc/jjaa185 PMC 바로가기 [Article Type] Article
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populationsMycobacterium tuberculosis 감염에 대한 내성에 대한 게놈 차원의 연관성 연구는 3개의 별개 집단에서 10q26.2의 유전자좌를 확인합니다Research Article Published on 2021-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95%CI activating ADAM12 allele Analysis association C10orf90 characterized chromosome Cluster Cohort Contact decreased expression defined Diagnosis ENCODE Endemic enrolled epidemiological Evidence exposure to France French Genome-wide association study genome-wide significant genotyped household contact household contacts identify IFN-γ independent individual infected individual infected individuals Infection inter-individual interferon Interferon-gamma intronic region lead locus Lymphocytes monocyte Monocytes Mycobacterium tuberculosis natural history outcome p53 patients performed Population populations positive proportion Protective Release replicated selected shown skin Skin test South Africa subject Suppressor gene Test Th17 transcription factor TST Tuberculin tuberculin skin test Tuberculosis Tumor tumor suppressor tumor suppressor gene ubiquitin ligase upstream Variability variant variants [DOI] 10.1371/journal.pgen.1009392 PMC 바로가기 [Article Type] Research Article
mTOR inhibition: a double-edged sword in patients with COVID-19?mTOR 억제: COVID-19 환자의 양날의 검?Article Published on 2021-03-012022-08-31 Journal: Human Cell [Category] MERS, 신약개발, [키워드] Activation Cell cell growth Cell signaling COVID-19 disease effective drug effective drugs growth immune system Infection lack mammalian metabolism mTOR mTOR inhibitor mTOR inhibitors normal physiological conditions Pandemics Pathogenesis pathway Pathways Patient protein synthesis Rapamycin reactance Regulation researcher SARS-CoV-2 SARS-COV-2 infection signaling pathway specific treatment suggested therapeutic potential upstream Viral [DOI] 10.1007/s13577-021-00495-2 PMC 바로가기 [Article Type] Article