viral life cycle – Page 8 – Communicable Diseases Research

SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci

SARS-CoV-2 핫스팟 돌연변이는 역 반복 및 CpG 섬 유전자좌 내에서 상당히 풍부합니다

Case Study

Published on 2021-03-212022-09-10
Journal: Briefings in Bioinformatics [Category] SARS, 변종,

A novel cell culture system modeling the SARS-CoV-2 life cycle

SARS-CoV-2 수명 주기를 모델링한 새로운 세포 배양 시스템

Research Article

Published on 2021-03-122022-08-13
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent Antiviral antivirals approach Author biosafety biosafety level BSL-2 BSL-2 laboratory BSL-3 can be used cause Cell Cell culture cell line cells chloride Complete coronavirus COVID-19 Critical Culture culture system Deletion dissect drug effective evidenced experimental system expresse expressing facilitate genetic recombination genetics genomic GFP global pandemic impede independent intein life cycle MERS MERS-CoV N monensin monensin sodium N gene N protein neutralization nucleocapsid Nucleocapsid gene Particles passage Phosphorylation powerful tool producer cells Protein Proteins replacing Replication replication-competent SARS-CoV-2 reporter reporter gene required Research residue respiratory Salinomycin SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 virus secure Sequence analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium the cells the N protein the SARS-CoV-2 this system trans Transcription vector vectors Viral viral genome viral infection viral life cycle Viral RNA virion assembly Virus life cycle
[DOI] 10.1371/journal.ppat.1009439 PMC 바로가기 [Article Type] Research Article

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

Chemistry

Published on 2021-03-122022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

Coronavirus biology and replication: implications for SARS-CoV-2

코로나바이러스 생물학 및 복제: SARS-CoV-2에 대한 의미

Review

Published on 2021-03-012022-09-11
Journal: Nature reviews. Microbiology [Category] Coronavirus, SARS, 유전자 메커니즘, 치료제,

Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs

SARS-CoV-2에 대한 네트워크 분석 및 분자 매핑을 통해 약물 표적을 밝히고 임상적으로 개발된 약물의 용도 변경

Article

Published on 2021-03-012022-08-31
Journal: Virology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] (hydroxychloroquine) Analysis Antibiotics antimalarial antiretroviral Azithromycin BCL-2 biological process carried chemokine Chemokine receptor clinically Combination coronavirus dietary supplement dietary supplements disease networks docking docking analysis docking study drug drug combination Drug repurposing drug target effective EGFR ErbB Estrogen event FoxO global pandemic GnRH HIF-1 host inflammatory response Hydroxychloroquine IL-17 insulin Interaction involved Jak-STAT KEGG pathway analysis life cycle Lopinavir LOPINAVIR AND RITONAVIR MAPK modulation molecular molecular docking molecular mechanism morbidity and mortality mortality rate multiple pathway multiple pathways network Neurotrophin novel Novel coronavirus Ontology PARP pathway platelet activation predict PRKCB Process analysis receptor reduce Ritonavir SARS-CoV-2 SARS–CoV–2. signaling pathway STAT suggested target targets thyroid hormone TNF Toll-like receptor Treatment VEGF Viral viral infection viral infectivity viral life cycle viral replication virus Vitamin Vitamin C
[DOI] 10.1016/j.virol.2020.12.006 PMC 바로가기 [Article Type] Article

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus

글루코실세라마이드 합성효소 억제제는 SARS-CoV-2 및 인플루엔자 바이러스의 복제를 방지합니다

Accelerated Communication

Published on 2021-02-252022-09-10
Journal: The Journal of Biological Chemistry [Category] 비임상, 신종인플루엔자,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analogue antiviral drugs Antiviral effect antiviral therapies breath caused CC50, cytotoxicity concentration 50% cell membranes Cerdelga clinical trials component coronavirus COVID-19 COVID-19 pandemic CPE, cytopathic effect creating cross DENV, dengue virus dependency disrupt DMSO, dimethyl sulfoxide DNJ, deoxynojirimycin drug Drug administration DsiRNA, Dicer-substrate siRNA examined food GCS, glucosylceramide synthase GlcCer, glucosylceramide global health glucosylceramide glucosylceramide synthase GZ-161, GENZ-667161 GZ-346, Genz-123346 H1N1 Health host cell host cell membrane host cell membranes Infection Influenza Influenza virus inhibit inhibitor life cycle life cycles limit LSD, lysosomal storage disease MDCK, Madin–Darby Canine Kidney membrane MOI, multiplicity of infection NB-DNJ, N-butyl–DNJ not applicable outcomes Phase III clinical trials PR8, influenza virus A/PR/8/34 (H1N1) Prevent Replication replication of SARS-CoV-2 respiratory SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus SI, selective index specific inhibitor specific inhibitors sphingolipids Support synthesis the United State therapeutic target Treatment United States Vaccine venglustat Viral viral life cycle virus viruses
[DOI] 10.1016/j.jbc.2021.100470 PMC 바로가기 [Article Type] Accelerated Communication

A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL pro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19

Vaccines and Antiviral Agents

Published on 2021-02-232022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] 3CL pro A549 ACE2 acute respiratory syndrome airway airway epithelium alveolar Analysis Antiviral Antiviral compound antiviral drug approach approved Cell cells clades clinical trials Comparative complex component concentrations coronavirus coronavirus disease COVID-19 cultures develop direct-acting drug candidate effective Efficacy epithelial epithelial cell etiological agent Evidence experiment Express GC-376 Human airway epithelium human airway epithelium cultures in vitro in vitro model inhibit SARS-CoV-2 inhibitor kidney M pro New P-glycoprotein polymerase polyprotein Potential protease provide regimen Remdesivir SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 protease Side effect suggested targets the SARS-CoV-2 the timing time-of-addition experiments treat VERO E6 cells viral life cycle
[DOI] 10.1128/JVI.01819-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro

Article

Published on 2021-02-112022-10-28
Journal: Viruses [Category] COVID-19, MERS,

Trajectory of individual immunity and vaccination required for SARS-CoV-2 community immunity: a conceptual investigation

Life Sciences–Mathematics interface

Published on 2021-02-032022-10-30
Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS,

Structure of Nonstructural Protein 1 from SARS-CoV-2

SARS-CoV-2의 비구조 단백질 1의 구조

Article

Published on 2021-01-282022-09-11
Journal: Journal of Virology [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Antiviral antiviral therapy carboxyl causative agent cellular city clone conformation coronavirus Coronavirus replication CoV COVID-19 COVID-19 pandemic CoVs Critical crystal structure cultured cells Deletion effective vaccine Effective vaccines element facilitate Factor Features flexible function Health high-resolution crystal structure Host host cell infecting inhibit innate immune response life cycle live-attenuated vaccines mechanism molecular mRNA degradation Mutation nonstructural protein 1 Novel coronavirus novel coronaviruses nsp1 Occurrence Pneumonia prevented promote Protein public health recruited respiratory Respiratory illness reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 NSP1 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory illness shown Structure structure-function Support target therapeutic option translation turn underlie Vaccine design Vaccine development Viral viral life cycle virus virus infection Wuhan Wuhan, China X-ray X-ray crystallography
[DOI] 10.1128/JVI.02019-20 PMC 바로가기 [Article Type] Article