Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian PeninsulaCoronaviruses Published on 2021-12-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, [키워드] adaptive alpaca Amino acid amino acid substitution Analysis animal Antiviral Arabian Peninsula binding caused clade decrease difference double-stranded elicited enhanced Epidemic explain Frame hosts Human Hypothesis IFN IFN response immunological parameters in vivo infecting Infection inoculated interferon-stimulated gene ISGs MERS-CoV Middle East Middle East respiratory syndrome Coronavirus moderate motif nasal nasal mucosa orf4a post inoculation Protein Replication replicative reported respiratory syndrome coronavirus respiratory tract RNA S proteins strain subsequent Transcription Transmission variant viral loads viral shedding Virological virus while [DOI] 10.1080/22221751.2021.2019559 PMC 바로가기 [Article Type] Coronaviruses
SARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in GermanyPublic Health Published on 2021-12-132022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, SARS, [키워드] Adults affected age Analysis attack rates capillary blood Care children clinical symptom collected contribute COVID-19 COVID-19 pandemic COVID-19 symptom Day day care center described epidemiological Germany Health status include index case information measure nose swab parent polymerase chain positive Prospective Protective real-time RT-PCR reported resolved respiratory sample retrospective reverse transcription Saliva SARS-CoV-2 SARS-COV-2 infection secondary infection rate shedding relative Stool Study design subsequent susceptibility Symptom symptom onset Symptoms tested Transmission Transmission dynamics viral clearance viral shedding Virological [DOI] 10.3389/fpubh.2021.773850 PMC 바로가기 [Article Type] Public Health
The first familial cluster of the B.1.1.7 variant of SARS-CoV-2 in the northeast of Italy이탈리아 북동부의 SARS-CoV-2 변종 B.1.1.7의 첫 번째 가족 클러스터Case Reports Published on 2021-12-012022-09-11 Journal: Infection [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis attack rate B.1.1.7 B.1.1.7 variant Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 epidemiological Hospitalization Infection infective involved Italy pathway performed Pneumonia SARS-CoV-2 severe acute respiratory syndrome Coronavirus UK variant. variant Virological [DOI] 10.1007/s15010-021-01609-6 PMC 바로가기 [Article Type] Case Reports
An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19코로나19로 입원한 환자를 대상으로 한 로피나비르/리토나비르, 로피나비르/리토나비르 + IFN-β-1a 및 히드록시클로로퀸의 효과에 대한 공개 무작위 대조 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] 임상, 치료제, [키워드] 95% confidence interval 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adjusted odds ratio adults hospitalized age analyses Arm ARMS clinical status conducted Controlled trial coronavirus coronavirus 2019 disease COVID-19 evaluated expected hospitalized patient Hydroxychloroquine Inpatient intention-to-treat population Interferon β-1a IQR Lopinavir LOPINAVIR AND RITONAVIR Lopinavir/ritonavir male median age multicentre no significant effect not improved Occurrence Open-label Ordinal Scale outcome oxygen participant pharmacokinetic plasma concentration Primary outcome quantification Randomized Randomized controlled trial regimen Remdesivir respiratory specimen respiratory specimens respiratory tract specimens Ritonavir SARS-CoV-2 SARS-CoV-2 clearance secondary Secondary outcomes Serious Adverse Event Serious Adverse Events seven-point ordinal scale severe acute respiratory syndrome Coronavirus severe disease significant effect significantly higher solidarity Solidarity trial Standard of care the median the WHO treat Treatment Trial trough ventilatory support Virological with COVID-19 [DOI] 10.1016/j.cmi.2021.05.020 PMC 바로가기 [Article Type] Clinical Trial
Serologic response to COVID-19 infection and/or vaccine in cancer patients on active treatment활성 치료 중인 암 환자의 COVID-19 감염 및/또는 백신에 대한 혈청학적 반응Article Published on 2021-12-012022-09-11 Journal: ESMO open [Category] SARS, 변종, 치료법, [키워드] active treatment anti-S Anti-S1 antibody antibody response rate Antibody titer biologic BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine booster Cancer cancer patient Cancer patients Chemotherapy Chemotherapy treatment Cohort control group COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines domain dose evaluated Health care Health care worker humoral identify Immunocompromised Immunocompromised patient Immunocompromised patients immunogenic immunogenicity Immunologic immunologic response Immunotherapy Infection less metastatic disease multiple regression model natural infection Neutralizing antibody titer Odds ratio other treatment other treatments Patient positive positive response reduced response rate S1/S2 SARS-CoV-2 variant SARS-CoV-2 variants serologic Serologic response serologic test serologic tests serological surveillance shown significantly solid tumor solid tumors Specific subgroup subgroups the SARS-CoV-2 Treatment tumors vaccination Vaccine vaccine doses Virological were measured [DOI] 10.1016/j.esmoop.2021.100283 PMC 바로가기 [Article Type] Article
Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China중국 광저우에서 입원한 코로나19 환자의 종적 바이러스학적 변화와 기저 병인Article Published on 2021-12-012022-09-11 Journal: Science China. Life sciences [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 average change Chest computed tomography Clinical outcome Complete Computed tomography coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients disease expression Factors false discovery rate Guangzhou, China hospitalized COVID-19 patient Host host gene host gene expression IL1R1 IL1R2 in some laboratory-confirmed longitudinal longitudinal virological changes Mutation occur occurred Pathogenesis Patient patients positive positively correlated Prolonged recruited recurrence reported respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR severe acute respiratory syndrome Coronavirus significantly specific antibodies specific antibody SRAS-CoV-2 symptom onset TNFRSF21 Viral viral genome viral mutation Viral mutations Viral RNA Viral RNA shedding viral shedding Virological [DOI] 10.1007/s11427-020-1921-5 PMC 바로가기 [Article Type] Article
Real-world deployment of lateral flow SARS-CoV-2 antigen detection in the emergency department to provide rapid, accurate and safe diagnosis of COVID-19Research article Published on 2021-12-012022-10-05 Journal: Infection Prevention in Practice [Category] 치료기술, [키워드] antigen detection asymptomatic patient COVID-19 COVID-19 patient defined Diagnosis diagnosis of COVID-19 Disease prevalence effective emergency department evaluation period False positive false-negative finding infection control Laboratory lateral flow Lateral flow viral antigen detection devices LFD Metrics NHS Non-COVID-19 Nosocomial transmission NPV Patient POC PPV Prevalence review RT-PCR Safe SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 testing Sensitivity and specificity trace track Universal Virological [DOI] 10.1016/j.infpip.2021.100186 [Article Type] Research article
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication423 Published on 2021-11-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding [DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423
Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients성인 입원 환자에서 인플루엔자 A (H1N1) 및 SARS-COV-2에 대한 단일 및 이중 감염의 임상 및 바이러스 학적 영향Research Article Published on 2021-11-292022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단, 치료기술, [키워드] Acute heart failure Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus Admission admittance Adult patients adults hospitalized adverse event adverse events affected All participant All participants All the patient all the patients ARDS Bacterial infections baseline both virus both viruses caused China clinical Clinical outcome Clinical severity clinical status Clinical symptoms Co-infection Coinfection Comprehensive coronavirus COVID-19 pandemic Ct value Ct values demographic described diagnosis of COVID-19 diagnostics electronic medical record electronic medical records enrolled Epidemic Frequency future therapeutic groups Guangdong Guangzhou H1N1 H1N1 infection heart failure Hospitalization Hospitalized ICU incidence Infection Influenza influenza A initial Inpatient Inpatients laboratory data Lower mechanism median medical records molecular nasopharyngeal swabs Older age Ordinal Scale Patient patients patients hospitalized PCR cycle positively correlated Prevalence prevalence rate Prophylactic respiratory SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection score Seasonal influenza Secondary bacterial infections seven-category ordinal scale severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significantly Symptom tested threshold trajectory Transmission Treatment Viral Viral load Viral RNA viral RNA detection Virological virus viruses were assessed with COVID-19 [DOI] 10.1371/journal.pntd.0009997 PMC 바로가기 [Article Type] Research Article
Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology