virus variants – Page 8 – Communicable Diseases Research

Chemoprophylaxis trial designs in epidemics: insights from a systematic review of COVID-19 study registrations

전염병에 대한 화학 예방 실험 설계: COVID-19 연구 등록에 대한 체계적인 검토에서 얻은 통찰력

Review

Published on 2021-05-292022-09-10
Journal: Trials [Category] SARS, 변종, 치료기술, 치료제,

Scalable, Micro-Neutralization Assay for Assessment of SARS-CoV-2 (COVID-19) Virus-Neutralizing Antibodies in Human Clinical Samples

인간 임상 샘플에서 SARS-CoV-2(COVID-19) 바이러스 중화 항체 평가를 위한 확장 가능한 미세 중화 분석

Article

Published on 2021-05-122022-09-01
Journal: Viruses [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies antibody approach assessment Blood Cell clinical convalescent patient Convalescent patients convalescent plasma coronavirus COVID COVID-19 criteria Critical Diagnosis effective high-content imaging Human infected cells Interpretation MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus neutralization Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody neutralizing titers number of infected pandemic provide provided quantitative assessment reduction respiratory respiratory syndrome coronavirus robust Sample SARS-CoV SARS-CoV-2 serum sample serum samples severe acute respiratory syndrome Coronavirus subjective interpretation the SARS-CoV-2 therapeutic therapeutic approaches virus variants
[DOI] 10.3390/v13050893 PMC 바로가기 [Article Type] Article

COVID-19 vaccination and critical care capacity: Perilous months ahead

COVID-19 예방 접종 및 중환자 치료 능력: 앞으로 몇 달 동안 위험한 상황

Article

Published on 2021-04-152022-09-11
Journal: Vaccine [Category] 변종,

[키워드] Abstract Control COVID-19 vaccination Critical care Non-pharmaceutical intervention SARS-CoV-2 Vaccines variants virus variants
[DOI] 10.1016/j.vaccine.2021.03.035 PMC 바로가기 [Article Type] Article

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다

Clinical Trial

Published on 2021-04-082022-08-13
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제,

[키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Analysis Antibody binding Antiviral antiviral drug antiviral therapies antiviral therapy applied approach arising autologous antibodies binding Cell culture clearance Clinical outcome Clustering contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-sectional analysis detect detectable domain epitope evade Evolution exhibit Frame furin furin cleavage site Genetic genetic diversity Genome genomic RNA Haplotype help Humoral immunity immune response immune responses Immune-mediated in vitro in vivo increase in independent individual individuals with COVID-19 infected individual infected individuals infecting initial intra-individual longitudinal analysis Mutation mutations Non-synonymous mutation NTD one individual participant Pathogenesis predominant regions respiratory reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 replication SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants selected selection of variant sequence Sequencing sequencing technology serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein study participant surface protein surface proteins susceptibility the SARS-CoV-2 Time frame upper respiratory sample variant variants Variation virion virus virus RNA virus variants viruses WA-1 reference with COVID-19
[DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

SARS-CoV-2에 대한 조작된 미끼 수용체는 단백질 S 서열 변이체에 광범위하게 결합합니다

Research Article

Published on 2021-02-172022-08-13
Journal: Science Advances [Category] Biochemistry, 변종,

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

S1/S2 절단 부위에 돌연변이가 있는 SARS-CoV-2 변이체는 TMPRSS2 결핍 세포에서 증식하는 동안 시험관 내에서 생성됩니다

Research Article

Published on 2021-01-212022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19,

[키워드] alteration antivirals bind Cell cell lines cell tropism cleavage cleavage site cleaved Coronaviruses Critical de novo demonstrated direct fusion dominant entry pathway exhibited experiments facilitate generate Host host cell host cell receptor host protease in vitro inefficient infect motif mutant mutants Mutation performed plaque plaques polybasic Protein proteolytic cleavage researcher respiratory S gene S protein S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation SARS-CoV-2 S gene SARS-CoV-2 variant SARS-CoV-2 variants screened Serine Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 shown target cells the cell the S protein TMPRSS2 transmembrane serine protease Transmissibility type strain undergo Vaccine variant Vero Cell Vero cells Viral viral entry virus virus strains virus variants viruses wild-type strain
[DOI] 10.1371/journal.ppat.1009233 PMC 바로가기 [Article Type] Research Article

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다

Article

Published on 2020-11-302022-09-11
Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단,

[키워드] abrogate ACE2 ACE2‐Fc activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin II antibody block cascade caused cells cellular receptor Characteristics circumvent coronavirus COVID‐19 COVID‐19 cytokine D614G variant D614G variants decoy antibody degranulation demonstrated develop domain effective enzyme fusion protein H1975 humanized immunology impairment Infection Interaction lung cell lung cells lung organoids Microbiology, Virology & Host Pathogen Interaction NK cell not affected pandemic peptidase preservation Prevent Pseudotyped virus reduce respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus shown Spike protein Strains therapeutic Treatment Viral viral entry viral spike protein virus infection virus replication virus variants
[DOI] 10.15252/emmm.202012828 PMC 바로가기 [Article Type] Article

Tracking SARS-CoV-2 in Sewage: Evidence of Changes in Virus Variant Predominance during COVID-19 Pandemic

Article

Published on 2020-10-092022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

[키워드] alter surveillance system approach can be used change changes in clinical sample Concentration coronavirus 2 coronavirus disease COVID-19 detect Effect England evidence of faece FIVE identify Infection investigated lockdown Measures MONITOR Next-generation sequencing nucleotide sequence pandemic polymorphism prevalent Protein reduction Region reported respiratory responsible RT-PCR RT-qPCR assay SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 RNA SARS-CoV-2 transmission sensitivity sequence spike Surveillance variant variant G614 viral genome Viral RNA virus Virus evolution virus variant virus variants wastewater
[DOI] 10.3390/v12101144 PMC 바로가기 [Article Type] Article

Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of Recognition

Review

Published on 2020-10-062022-10-28
Journal: Vaccines [Category] COVID-19,

Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile

칠레에서 SARS-CoV-2의 유전적 변이 및 계통의 지리적 분포

Public Health

Published on 2020-09-222022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 America Analysis caused China construction coronavirus country COVID-19 D614G database Epidemiology Europe generate Genetic Genetic variant genetic variants Genome genomic variation genomic variations help impacted Infection information Lineage lineage B.1 lineages measure MONITOR Occurrence pandemic protocol protocols public health Region regions respiratory SARS-CoV- 2 SARS-CoV-2 Scientific community similarity USA variant variants Viral viral genome viral genomes viral sample viral samples viral variant Viral variants virus virus variant virus variants
[DOI] 10.3389/fpubh.2020.562615 PMC 바로가기 [Article Type] Public Health