Severity Assessment of COVID-19 Using a CT-Based Radiomics ModelResearch Article Published on 2021-09-272022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] Algorithm analyzed assessment AUC build Classifier coronavirus disease COVID-19 COVID-19 patient COVID-19 patients determine diagnostic feature Features fixed four group group groups inefficient lesion Model outbreak Precision progression radiologist Randomly recall receiver operating characteristic ROC severity severity of COVID-19 Stage Support SVM test dataset the disease the patient training dataset worldwide pandemic [DOI] 10.1155/2021/2263469 PMC 바로가기 [Article Type] Research Article
The Effectiveness of Convalescent Plasma for the Treatment of Novel Corona Virus Disease 2019: A Systematic Review and Meta-AnalysisMedicine Published on 2021-09-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 28-day mortality 95% CI Analysis antibody CBM CCP CNKI conducted control group convalescent plasma Corona Coronavirus disease 2019 COVID-19 criteria Critical critical COVID-19 patient Efficacy and safety enrolled Evidence group hospital Hospital stay ICU ICU admission incidence Infection Inflammatory Intervention mechanical ventilation Meta-analysis Mortality mortality rate no significant difference novel Novel coronavirus overall mortality participant Patient patients with COVID-19 PICOS Placebo placebo group plasma Primary outcome Randomized controlled trial RCT RCTs reduce reducing review safety and efficacy searched secondary outcome Serious Adverse Events significant difference significantly significantly shorter SSRN subgroup analysis subject therapy Treatment treatment group treatments of COVID-19 VIP viral loads Web of Science worldwide pandemic [DOI] 10.3389/fmed.2021.641429 PMC 바로가기 [Article Type] Medicine
COVID-19 Animal Models and Vaccines: Current Landscape and Future ProspectsReview Published on 2021-09-262022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addition animal animal model animal model application animal models clinical trial coronavirus coronavirus disease COVID-19 COVID-19 epidemic COVID-19 vaccine current drugs Effectiveness Efficacy etiological agent ferrets Future global public health hallmark hamsters Inactivated Vaccines information involved landscape mice Model mRNA SARS-CoV-2 subunit vaccines susceptible therapeutic therapeutic drug Vaccine vaccine candidate vaccine candidates Vaccine development Vaccines widespread worldwide pandemic [DOI] 10.3390/vaccines9101082 PMC 바로가기 [Article Type] Review
Pattern Recognition Proteins: First Line of Defense Against CoronavirusesImmunology Published on 2021-09-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome adaptive Adaptive immune response Affect affecting Against apoptotic cell ATH - atherosclerosis atherosclerotic lesions C-reactive protein C1q cardiovascular complication cardiovascular system caused clearance combination treatment complement Complication composed coronavirus Coronaviruses COVID- 19 COVID-19 COVID-19 disease death development Direct Effect enhancement global healthcare host’s immune system IgM antibodies immune Immunity Innate innate and adaptive IgM antibodies Innate immunity involved killing LINE lung novel coronavirus SARS-CoV-2 outbreak pandemic patients with SARS-CoV-2 pattern pattern recognition proteins Prevent Prophylactic Protein Recognition recognition protein reduce RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 virus severe disease severe respiratory syndrome surfactant surfactant proteins A and D (SP-A and SP-D) the SARS-CoV-2 Therapeutic approach therapy Vaccine viral particle virus worldwide pandemic Wuhan, China [DOI] 10.3389/fimmu.2021.652252 PMC 바로가기 [Article Type] Immunology
A Reverse Transcription Recombinase-Aided Amplification Method for Rapid and Point-of-Care Detection of SARS-CoV-2, including Variants변이체를 포함하여 SARS-COV-2의 신속하고 관리 지점 검출을위한 역전사 재조합 효소 보조 증폭 방법Article Published on 2021-09-192022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 amplification caused circulating variant conserved Coronavirus-2 demonstrated detect detection Diagnosis diagnostic eight equipment expected point-of-care primer Primers probe probes Rapid respiratory respiratory RNA viruses reverse transcription RT-qPCR RT-RAA SARS-CoV-2 SARS-CoV-2 strains sensitivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity specimen temperature time-consuming variant variants variants of concern variants of interest VoC VOCs VOIs was used worldwide pandemic [DOI] 10.3390/v13091875 PMC 바로가기 [Article Type] Article
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.Research Article Published on 2021-09-172022-08-13 Journal: PLoS Pathogens [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] absence accumulation acting Affect animal model animal models Antiviral antiviral drug approved Author backbone changes in characterisation circulating SARS-CoV-2 variant Clinical management conserved coronavirus COVID-19 patients displaying drug-resistant EIDD2801 Evidence evidence of excess FDA FDA approval Frequency genetics immune immune pressure immune selection implication in vitro indicate low frequency morbidity and mortality mutants Mutation no evidence of not affect Nsp12 nucleoside occurred overcome passage patients polymerase Population predicted provide RDV Remdesivir replication advantage residue resistant mutants responsible risk RNA virus RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selected sensitivity Sequencing single mutation small molecule Substitution substitutions Surveillance the SARS-CoV-2 genome Transmission Treatment treatment of COVID-19 patients variants of concern Viral viral replication virus viruses widespread worldwide pandemic [DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article
Animal Shelters’ Response to the COVID-19 Pandemic: A Pilot Survey of 14 Shelters in the Northeastern United StatesArticle Published on 2021-09-102022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] adopted adoption affected Anecdotal animal animal shelter Care cat change COVID-19 COVID-19 pandemic dog euthanasia euthanized Evidence expand FIVE foster care greater not differ offer outcome pandemic peer-reviewed proportion provide recruit reported response significantly significantly lower simple Support survey t -test United State United States Variability were used while widespread Wilcoxon signed-rank test worldwide pandemic [DOI] 10.3390/ani11092669 PMC 바로가기 [Article Type] Article
[Impact of family restrictions during COVID-19 pandemic on the use of physical restraint in an acute hospital: An observational study]Observational Study Published on 2021-09-012022-10-05 Journal: Journal of healthcare quality research [Category] 임상, [키워드] Care caused clinical history collected Contención mecánica coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic Del diagnostic English Estudio prevalencia evaluated hospital Hospital admission hospitalized patient hospitalized patients increase in information Injury material measure Pacientes hospitalizados Pandemia pandemic of COVID-19 patient safety patients physical Physical restraint Prevalence primer restrict SARS-CoV-2 Seguridad del paciente. Sex Spanish statistically significant the patient worldwide pandemic [DOI] 10.1016/j.jhqr.2021.04.005 PMC 바로가기 [Article Type] Observational Study
What GI Physicians Need to Know During COVID-19 PandemicCOVID-19 팬데믹 동안 소화기 의사가 알아야 할 사항Review Published on 2021-09-012022-09-11 Journal: Digestive diseases and sciences [Category] SARS, 치료기술, [키워드] abnormality ACE-2 receptor anorexia appear caused cell line clearance confounding factor COVID-19 detected in stool diarrhea elevated enzyme Evidence General population GI symptom GI symptoms GI Tract host cells hypoxia infection rate infection rates involved liver Liver disease liver enzyme liver enzymes Liver manifestations: GI symptoms Loss of Smell management medications Mild morbidity and mortality Mortality nausea Patient patients patients with COVID-19 pharyngeal physician proportion recommendation Respiratory illness RNA SARS-CoV-2 Sepsis severe disease Severity of disease Stool Transmission Viral RNA virus vomiting worldwide pandemic [DOI] 10.1007/s10620-020-06625-4 PMC 바로가기 [Article Type] Review
Epidemiological study using IgM and IgG antibody titers against SARS-CoV-2 in The University of Tokyo, Japan (UT-CATS)일본 도쿄대학(UT-CATS)에서 SARS-CoV-2에 대한 IgM 및 IgG 항체 역가를 이용한 역학 연구Article Published on 2021-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected age antibody Antibody test antibody tests Antibody titer Antibody titers Asymptomatic blood sample chemiluminescent immunoassay Chemiluminescent immunoassay (CLIA) CLIA Clinical course Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutoff value determine Factors FIVE Gender health information healthy subject iFlash IgG IgG and IgM IgG antibody IgG antibody titers IgM IgM and IgG immunoassay infection with SARS-CoV-2 Japan median titer participant Participants positive positive rates qualitative detection questionnaire recruited required respiratory SARS-CoV-2 Seroepidemiological study serum serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) smoking status survey the patient titer Tokyo university Volunteer worldwide pandemic [DOI] 10.1016/j.jiac.2021.06.008 PMC 바로가기 [Article Type] Article