Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal InfectionResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] acute respiratory syndrome approved attenuate attenuated vaccine C-terminal domain Cell culture coronavirus coronavirus SARS-CoV-2 Coronaviruses Deletion described dose E protein genetics genome engineering highly pathogenic immune responses immunization indicate induce Interaction killing knowledge lethal life-threatening long-lasting MERS-CoV Middle East mutant mutants passage Pathogenesis protection Protein provided Research respiratory respiratory syndrome coronavirus Safe SARS-CoV selected signaling pathway Vaccine vaccine candidate Vaccines virulence virulent virus virus replication [DOI] 10.1128/mBio.00103-21 PMC 바로가기 [Article Type] Research Article
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19MIS-C의 심층 면역 프로파일링은 성인 및 소아 COVID-19에 비해 현저하지만 일시적인 면역 활성화를 보여줍니다Research Articles Published on 2021-03-022022-09-12 Journal: Science Immunology [Category] 진단, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Admission adult disease Adults analyzed antibody ARDS CD8+ T cell CD8+ T cells characterized children Clinical improvement Complication correlated COVID-19 COVID-19 patient CX3CR1 death deep defined disease elevated feature Frequency Hospitalization Hospitalized illness immune immune activation immune profiling immune response immune responses immune signature lymphocyte lymphopenia medication MIS-C Patient pediatric Pediatric patient Peripheral blood respiratory distress robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific severely ill adults Shock specific antibodies subset sustained syndrome T cell T cell activation T cells trajectory Vascular Vasoactive [DOI] 10.1126/sciimmunol.abf7570 PMC 바로가기 [Article Type] Research Articles
Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini reviewCOVID-19 시대의 포도당-6-인산 탈수소효소 결핍과 하이드록시클로로퀸: 미니 리뷰Review Published on 2021-03-012022-09-11 Journal: Molecular biology reports [Category] MERS, 신약개발, 진단, 치료제, [키워드] activities addition antiviral agent Antiviral agents association caused Cellular immune response Chloroquine coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine deficiency effective effective drug effective drugs effort Final G6PD G6PD deficiency glucose-6-phosphate dehydrogenase deficiency HCQ health emergency hemoglobin Hemolysis hemolytic hemolytic anemia Hemolytic crisis Hydroxychloroquine immune responses in vitro inflammasome activation Innocent Intensive involved limelight modulating occur oxygen Patient patients performed Prevent pro-inflammatory cytokine question raised reactive oxygen species reactive oxygen specy Safe searched shown today treat [DOI] 10.1007/s11033-021-06234-y PMC 바로가기 [Article Type] Review
Closing the serological gap in the diagnostic testing for COVID-19: The value of anti-SARS-CoV-2 IgA antibodiesArticle Published on 2021-03-012023-06-19 Journal: Journal of medical virology [Category] MERS, SARS, [키워드] Antiviral agents immune globulin immune responses Immunoglobulin SARS Coronavirus virus classification [DOI] 10.1002/jmv.26422 PMC 바로가기
Cocirculation of COVID-19 and dengue: A perspective from PakistanArticle Published on 2021-03-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] coronavirus dengue virus Humoral immunity immune responses virus classification [DOI] 10.1002/jmv.26567 PMC 바로가기
At the Crossroads: COVID-19 and Immune-Checkpoint Blockade for Cancer갈림길에서: COVID-19와 암에 대한 면역 관문 차단Article Published on 2021-03-012022-09-11 Journal: Cancer immunology research [Category] 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral immune response antiviral immune responses blockade Cancer Characteristics clinical trials Complication complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination death decrease detrimental disease course Effect Evidence expression heterogeneity immune responses immunomodulatory effect immunomodulatory effects infections Inflammatory inflammatory complications Inflammatory response Inflammatory responses interferon interferon signaling leads Ligand MOST pathway Patient patients Patients with cancer PD-L1 PD1 PROTECT provided receiving receptor respiratory respiratory distress Respiratory distress syndrome RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases Severe respiratory distress Support syndrome the disease therapy Viral viral infection virus infections worsening [DOI] 10.1158/2326-6066.CIR-21-0008 PMC 바로가기 [Article Type] Article
Results from a survey in healthy blood donors in South Eastern Italy indicate that we are far away from herd immunity to SARS-CoV-2이탈리아 남동부의 건강한 헌혈자를 대상으로 한 설문조사 결과에 따르면 SARS-CoV-2에 대한 집단 면역과는 거리가 멀다고 합니다.Article Published on 2021-03-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody Apulia Containment measure coronavirus coronavirus disease demonstrated healthy blood donor humoral Humoral immunity immune immune responses Immunity incidence Italy nasopharyngeal swabs nine pandemic Patient polymerase chain public policy reported Research Result reverse transcription SARS Coronavirus SARS-CoV-2 seropositive social science South Spread subject tested Viral RNA virus virus classification [DOI] 10.1002/jmv.26425 PMC 바로가기 [Article Type] Article
Late onset infectious complications and safety of tocilizumab in the management of COVID-19COVID-19 관리에서 늦은 발병 감염성 합병증 및 토실리주맙의 안전성Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 진단, 치료제, [키워드] 48 hours Admission Allergic reactions Bacterial chemokine clinical trial Complication concern control group coronavirus COVID-19 COVID-19 patients CRS cytokine Cytokine release syndrome cytokine/chemokine diverticulitis Efficacy elevated Elevation evaluate evaluated greater hypertension IL-6 IL-6 inhibition immune immune responses incidence Infection infectious complication infusion Inpatient intensive care intensive care unit admission Liver function test liver function tests management mechanical ventilation mortality rate MOST neutropenia occurred Patient Pneumonia Reactions receiving risk of infection SARS Coronavirus significantly more TCZ Tocilizumab toxicities Toxicity weighed while with COVID-19 [DOI] 10.1002/jmv.26429 PMC 바로가기 [Article Type] Article
Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2SARS-CoV-2의 단일 균주의 비강 내 저용량으로 햄스터 및 흰 족제비 실험 감염Article Published on 2021-03-012022-09-11 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Antiviral strategies Brain can be used clinical disease COVID-19 drugs excretion experimental animal model experimental model experimental models ferret ferrets French hamster hamsters immune response immune responses in vivo individual Infection infection levels inoculation intranasal Kinetics low dose lung Lungs Medulla oblongata Mild oblongata olfactory olfactory bulb Pathogenesis pathogenicity pathology protective effect remained resolved RNA SARS-CoV-2 SARS-COV-2 infection serological response severe disease severity the disease the SARS-CoV-2 therapeutic strategy understanding undetectable Viral Viral RNA virus [DOI] 10.1099/jgv.0.001567 PMC 바로가기 [Article Type] Article
BNT162b2 mRNA COVID-19 Vaccine: First ApprovalBNT162b2 mRNA COVID-19 백신: 첫 번째 승인Review Published on 2021-03-012022-09-11 Journal: Drugs [Category] SARS, 신약개발, 임상, [키워드] active immunization acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered age Antigen approval approvals Bahrain BNT162b2 BNT162b2 mRNA Canada caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 elicit Emergency use Emergency use authorization ENCODE EUA expression immune response immune responses immunization individual Infection intramuscularly Novel coronavirus novel coronavirus disease nucleoside nucleoside-modified mRNA of BNT162b2 Older Pfizer Prevent prevention of COVID-19 recipients respiratory SARS-CoV-2 SARS-CoV-2 spike protein Saudi Arabia severe acute respiratory syndrome Coronavirus Spike protein Switzerland the SARS-CoV-2 two-dose regimen USA Vaccine [DOI] 10.1007/s40265-021-01480-7 PMC 바로가기 [Article Type] Review