immune responses – Page 83 – Communicable Diseases Research

BNT162b2 mRNA COVID-19 Vaccine: First Approval

BNT162b2 mRNA COVID-19 백신: 첫 번째 승인

Review

Published on 2021-03-012022-09-11
Journal: Drugs [Category] SARS, 신약개발, 임상,

COVID-19 and autoimmune diseases

코로나19와 자가면역질환

Review

Published on 2021-03-012022-09-11
Journal: Current opinion in rheumatology [Category] SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome association Asymptomatic autoantibodies Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmune response autoimmune responses Autoimmunity caused clinical manifestations conditions coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients cross-reactivity develop disease evaluate hallmark host cells immune reaction immune response immune responses infected individual infected individuals Infection infection risk infection with SARS-CoV-2 Infectious disease lupus erythematosus medication organ Pathogenesis pathogenic mechanisms Patient patients with COVID-19 Prevent Prognosis proportion recent regimen reported respiratory risk of COVID-19 SARS-CoV-2 self-tolerance Severe acute respiratory syndrome severe COVID-19 infections severe disease similarities similarity syndrome systemic lupus erythematosus therapeutic effect treat Trigger
[DOI] 10.1097/BOR.0000000000000776 PMC 바로가기 [Article Type] Review

The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates

COVID-19에 감염된 임산부와 신생아의 대사 및 면역학적 특성

Article

Published on 2021-03-012022-09-11
Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 진단, 치료기술,

[키워드] amniotic Amniotic fluid analyzed Birth Blood blood sample Blood samples coagulation disorders collected complications COVID-19 COVID-19 infection D-dimer detect dysregulation Fever Health health problems high risk hypercoagulable Hypercoagulable state hyperfibrinolysis IgG immune responses immunological characteristics in urine Inflammatory response Inflammatory responses intrauterine infection Intrauterine transmission IQR ketone ketone body ketonuria LDH lead leukocyte leukocytes Neonate Neonates neutrophil Neutrophils organ Placenta positive Pregnancy pregnancy complications Pregnancy metabolic complications pregnant patient pregnant patients pregnant women problem raised Result SARS-CoV-2 SARS-CoV-2 IgM SARS-COV-2 infection severe complications Transmission uric acid Urine with COVID-19
[DOI] 10.1007/s10096-020-04033-0 PMC 바로가기 [Article Type] Article

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도

Article

Published on 2021-03-012022-09-12
Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법,

[키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water
[DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article

The Role of the Host Ubiquitin System in Promoting Replication of Emergent Viruses

Review

Published on 2021-02-262022-10-28
Journal: Viruses [Category] COVID-19,

A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation

W4P 돌연변이가 있는 B형 간염 바이러스 preS1의 아미노 말단 영역에 융합된 수용체 결합 도메인(RBD)의 키메라 단백질을 암호화하는 SARS-CoV-2에 대한 새로운 DNA 백신

Immunology

Published on 2021-02-262022-09-11
Journal: Frontiers in Immunology [Category] MERS, 변종, 진단,

[키워드] Against BAL Blood Bronchoalveolar lavage caused cell-mediated immune response Cellular immune response chimeric coronavirus coronavirus SARS-CoV-2 COVID-19 demonstrated develop disease DNA DNA vaccine domain effective encoding evaluated experiment expressing feasibility fused global public health HBV HBV preS1 hepatitis B Hepatitis B virus highlighting humoral IgA IgG IL-6 immune responses Infection lung mice multiple cell line Mutation N-terminal neutralize novel pandemic Pneumonia PROTECT Protein RBD RBD protein Receptor-binding domain Receptor-binding domain (RBD) Region robust S1 protein Safe SARS-CoV-2 SARS-COV-2 infection sequence sera significantly TNFα Transcription translation Vaccine Viral Viral pneumonia W4P-RBD wild-type
[DOI] 10.3389/fimmu.2021.637654 PMC 바로가기 [Article Type] Immunology

A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach

신종 전염병의 맥락에서 T-세포 에피토프 발견 및 백신 설계를 가속화하기 위한 프로테옴 전체 면역정보학 도구: 민족 중심 접근

Immunology

Published on 2021-02-262022-09-11
Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘,

[키워드] accelerate Accuracy Analysis AUC build caused CD4+ T-cell CD8+ ChAdOx1 ChAdOx1 vaccine clinical trials comparable complicate Context contribute coronavirus country Coverage COVID-19 pandemic criteria disease distribution effective Emerging infectious disease Emerging infectious diseases emerging-infectious disease Epidemics epitope epitope clusters epitope density epitope discovery epitope mapping Epitope-based vaccine Epitopes Ethnic groups Ethnicity frequencies Frequency genetic polymorphisms geographic distributions glycoprotein HLA HLA allele HLA allele frequencies HLA allele frequency HLA alleles human leukocyte antigen immune response immune responses immune responsiveness immune system immunodominant immunoinformatics in silico Infectious diseases investigated Japanese leukocyte Mortality NetMHCpan optimization Pathogens peptide Phase III clinical trials polymorphism Population predicted protein antigen protein antigens proteome Region retrieved SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-like coronavirus spike glycoprotein T-cell T-cell epitope T-cell epitopes the SARS-CoV-2 utility vaccination Vaccination strategy Vaccinations Vaccine vaccine candidates Vaccine design vaccine-induced immune response vaccine-induced immune responses Variability Variation virus
[DOI] 10.3389/fimmu.2021.598778 PMC 바로가기 [Article Type] Immunology

An overview of some potential immunotherapeutic options against COVID-19

Review

Published on 2021-02-262022-10-04
Journal: International immunopharmacology [Category] MERS, 신약개발,

[키워드] Abstract ACE2-Fc acute respiratory syndrome administration anti-inflammatory drug antibodies approach approved candidate cascade cell-based therapies complement convalescent plasma coronavirus COVID-19 COVID-19 vaccine cytokine Effectiveness effort immune component immune responses immunomodulator Immunotherapy Improvements Inflammatory Inflammatory cytokines interferon involved kinase knowledge lack mechanism of action pandemic Passive Pathogenesis provided resulting SARS-CoV2 SARS-CoV2 infection severe cases syndrome targets the disease therapy for COVID-19 Vaccine Vaccines viral infection Virus neutralization with COVID-19
[DOI] 10.1016/j.intimp.2021.107516 PMC 바로가기 [Article Type] Review

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG는 외피 바이러스 반응을 특성화하고 COVID-19 심각성과 상관 관계가 있습니다.

Research Article

Published on 2021-02-262022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

[키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC amplify amplifying anti–SARS-CoV-2 IgG antibody antibody-dependent cellular cytotoxicity anticancer Antigen antigens Antiviral association Attenuated Virus B cell B cell response binding Blood blood cell Blood cells Blood Group C-reactive protein C-reactive protein (CRP cause Cell cellular circumvent Clinical outcome complement Concentration condition conserved coronavirus COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients cytokine Cytokine storm dengue virus destruction determined by disparate domain domains elevated Exacerbation example excessive inflammation Fc receptor Fc receptors FcγRIIIa foreign antigen foreign antigens fucose functions glycoprotein Glycoproteins glycosylation help hepatitis B Hepatitis B virus HIV host cell host cells humans Hypothesis IgG IgG antibody IgG immune response IgG response IgG responses IL-6 Immune cell immune response immune responses Immune-mediated Immunoglobulin Immunoglobulin G in some in vitro individual individuals induce initiate interleukin-6 invading pathogens investigated isotype Macrophage macrophages membrane Mild disease mild symptoms mRNA vaccines myeloid cells natural infection natural killer occur over Pathogens Pathologies pathology Patient patients plasma position proinflammatory Proinflammatory cytokine promote promoted Protective Protein Protein subunit receptor receptors Region report reported required respiratory response responses responses against SARS-CoV-2 Science Seroconversion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe symptom severe symptoms severity strength subclass subunit sugar surface protein target target cell target cells tested therapeutic therapeutic antibodies Treatment Trigger vaccination Vaccinations Vaccine variant Viral Viral load virus viruses with COVID-19 with mild disease
[DOI] 10.1126/science.abc8378 PMC 바로가기 [Article Type] Research Article

SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection

초기 비인두 감염에서 SARS-CoV-2 선천적 이펙터 연관성 및 바이러스 부하

Observational Study

Published on 2021-02-242022-09-01
Journal: Physiological Reports [Category] MERS, 임상, 진단,

[키워드] 95% CI ACE age ambulatory Antiviral antiviral gene antiviral protein antiviral responses applied association Biomarkers blocked BST cause Chain Reaction change characterized clinical outcomes clinical testing COVID‐19 cytokine Cytokines discrepancy disease disrupt early disease Effects elevated Evidence evidence of examined Host host shut‐off Hypothesis IFIT1 IFIT3 IFN IFN‐γ immune immune responses immunoassays individual Infection Inflammatory cytokines innate immune innate immune response innate immune responses Innate immunity interferon interferons ISG Modification multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Older age outcomes Patient polymerase chain polymerase chain reaction polymerase chain reaction assays Proinflammatory cytokine Protein proteomics Quantitative responses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease subsequent Symptom symptomatic patient systemic inflammatory tested transcribed transcript Transcription transcripts translated translation university Utah Viral viral infection Viral load widespread with infection
[DOI] 10.14814/phy2.14761 PMC 바로가기 [Article Type] Observational Study