PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling PathwayResearch Article Published on 2011-02-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation acute respiratory syndrome assays catalytic domain cells cellular complex conserved coronavirus cytoplasm deubiquitinase domain dose-dependent manner DUB ENCODE Evidence experiment finding identification IFN IFN signaling IFN signaling pathway IFN transcription IFN-β in vitro inactivated inactive Infection inhibit inhibited innate immune system IRF3 MHV-A59 mouse mouse hepatitis virus nonstructural protein 3 Nsp3 nuclear translocation overexpression Papain-like protease phosphorylate PLP2 Prevent principal Proteins receptor reduced Regulatory Replication reporter shown Spread supported target TBK1 TNF TRAF3 Treatment Type type I interferon upstream [DOI] 10.1371/journal.pone.0017192 PMC 바로가기 [Article Type] Research Article
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A VirusResearch Article Published on 2011-01-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Acidic Author bypasse bypassed cathepsin L Cell cellular cellular tropism circumvent compared Control cytoplasm described did not reduce Ebola Ebola virus Endocytic pathway ENhance example Express expression Factors Filovirus glycoprotein highly pathogenic IAV IFITM IFITM1 IFITM3 indicate Infection infectious influenza A virus inhibit inhibited innate immune system interfere late stage less limit lysosomal modulate murine observation pathogenic viruses pattern plasma membrane Protein Proteins pseudovirions receptor Replication restrict restriction restriction factor SARS Coronavirus SARS-CoV transmembrane transmembrane protein Treatment viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
Specific protein content of pools of plasma for fractionation from different sources: impact of frequency of donations분획을 위한 다양한 출처의 혈장 풀의 특정 단백질 함량: 기부 빈도의 영향Article Published on 2010-10-012024-08-23 Journal: Vox Sanguinis [Category] 폐렴구균 감염증, [키워드] albumin donor remuneration Immunoglobulin plasma donors Plasma fractionation Proteins [DOI] 10.1111/j.1423-0410.2010.01345.x PMC 바로가기
Structural and functional analysis of the hemagglutinin-esterase of infectious salmon anaemia virusArticle Published on 2010-04-142022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activities Ala Amino acid amino acid substitution Analysis Atlantic salmon bovine Bovine coronavirus catalytic site Combination determinant different disease domain enzymatic activity enzyme expression feature functional had no Hemagglutinin-esterase Hemagglutinin-esterase (HE) infectious Infectious salmon anaemia virus (ISAV) Influenza introduced molecular orthomyxovirus Protein protein structure Proteins purification Quantitative Receptor binding Receptor-destroying enzyme (RDE) Recombinant secretory HE (recHE) red blood cells representing resolved responsible selected Ser Serine Structural analysis Surface glycoprotein variants virulence virulent virus [DOI] 10.1016/j.virusres.2010.03.020 PMC 바로가기 [Article Type] Article
SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolaseResearch Published on 2010-02-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated Activation Amino acid Apoptosis cell proliferation cellular co-immunoprecipitation culture cell cytoplasm DNA repair DNA replication ENCODE expressing Frame Host Human human cell interact Interaction involved nucleotide ORF pathogenic processe Protein protein synthesis Proteins Regulation responsible RNA SARS Coronavirus SARS-CoV sequence homology shown tissue virus yeast [DOI] 10.1186/1743-422X-7-31 PMC 바로가기 [Article Type] Research
Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion ChannelResearch Article Published on 2009-07-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affecting alteration Anti-viral drugs antiviral strategy Author binding site C-terminal Cell channel characterized common cold coronavirus coronavirus protein described determined distribution drug design E protein embryonic kidney envelope envelope protein event expressed expressing feature form found full length HEK-293 Human humans in vitro inactivation infect inhibited inhibition Ion lethal disease mammalian cell mammals membrane Mild morphology N-terminal NMR pandemic Pathogenesis pharmacological target platform produced Protein Proteins provide reduced reported responsible SARS-CoV SARS-CoV E shown significantly Structure supported transmembrane domain Validity variety viral envelope viral pathogen viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV ReplicationResearch Article Published on 2008-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adopted assays biochemical complex coronavirus Coronavirus replication detected domain expressing found function in vitro Interaction Involvement mammalian mechanism molecular mechanisms multifunctional Nidovirale non-structural protein Nsp12 nsp14 Nsp3 platform Protein protein-protein interaction Proteins provided regulate reporter RNA genome SARS Coronavirus SARS-CoV sequence shown stimulated to screen Transcription unique Viral protein viruses [DOI] 10.1371/journal.pone.0003299 PMC 바로가기 [Article Type] Research Article
Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane FusionResearch Article Published on 2007-10-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 Cell culture change conformational change Cryo-electron microscopy domain fusion in viral initial Isolation membrane fusion molecular morphology occur produced Protein Proteins provide purified receptor Receptor binding reorganization SARS Coronavirus SARS-CoV shown spike subsequent transmembrane domains viral spike virion [DOI] 10.1371/journal.pone.0001082 PMC 바로가기 [Article Type] Research Article
Analysis of Intraviral Protein-Protein Interactions of the SARS Coronavirus ORFeomeResearch Article Published on 2007-05-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis Characteristics cloned complex coronavirus deleted different displaying expected expression function functional Genome genome-wide analysis growth in vitro interact Interaction interactions mammalian cells non-structural protein Nsp12 nsp13 nsp14 NSP2 Nsp9 open reading frames ORF Orf9b ORFeome pathogenicity performed positive predicted Protein protein interaction Proteins proteome Replication SARS-CoV shown stability tested Vero cells Viral proteins viral replication virus [DOI] 10.1371/journal.pone.0000459 PMC 바로가기 [Article Type] Research Article
Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer염증 및 암에 대한 지표로서의 인간 키티나제 및 키티나제 유사 단백질Review Published on 2007-05-032022-08-07 Journal: Biomarker Insights [Category] Biochemistry, [키워드] a major Activation AMCase Arthritis Asthma atherosclerotic atherosclerotic plaques Biomarker C-terminal chitin-binding domain Cancer cells cell proliferation chitin chitinase chitinase-like protein chitinase-like proteins chitinases Chitotriosidase chondrocyte chondrocytes circulation cirrhosis contribute cytokine detected diagnostic diagnostic and prognostic marker enzymatic activity enzyme epithelial cells examination family fibrosis found Gaucher Disease glucocorticoid Glucocorticoid treatment Glucocorticoids Glyco_18 Domain Glyco_18 domain-containing protein hepatic fibrosis Human human diseases Human Glyco_18 domain-containing proteins hydrolyse hydrolytic activity IL-4 Indicator Inflammatory bowel disease inherited lysosomal storage involved lipid-laden macrophage lipid-laden macrophages Macrophage macrophage activation macrophages marker mechanism mediators Migration murine murine lectin neutrophil Neutrophils Non-invasive Osteoarthritis overproduced Pathogenesis Patient Prognostic marker progression Protein Proteins regulated rheumatoid arthritis sensitivity Serum level SI-CLP Side effect Side effects solid tumors synovial cells Th2 cytokine Th2 cytokine IL-4 Th2-environment the cell therapy tissue tissues Tumor tumors unique upregulated YKL protein YKL proteins YKL-39 YKL-40 YM1 PMC 바로가기 [Article Type] Review