T cells – Page 83 – Communicable Diseases Research

COVID-19 and Systemic Lupus Erythematosus: Focus on Immune Response and Therapeutics

COVID-19 및 전신성 홍반성 루푸스: 면역 반응 및 치료에 초점

Review

Published on 2020-10-302022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

Immunoinformatic Analysis of SARS-CoV-2 Nucleocapsid Protein and Identification of COVID-19 Vaccine Targets

SARS-CoV-2 뉴클레오캡시드 단백질의 면역정보학적 분석 및 코로나19 백신 표적 식별

Immunology

Published on 2020-10-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법,

[키워드] Alpha Amino acid amino acids B cell B cells betacoronaviruses conserved Coronavirus disease 2019 COVID-19 Critical cross-reactive cross-reactivity determinant disease domain dominant effective epitope Epitopes facilitate focus generate homolog host immune system human coronaviruses identification identify immune response immune responses immunological infect information knowledge Major MHC I MHC II alleles modulate MOST N protein nucleocapsid nucleocapsid protein other coronavirus other coronaviruses predicted PROTECT Region resulting SARS-CoV-2 SARS-CoV-2 N protein sequence sequences severe acute respiratory syndrome coronavirus 2 spike glycoprotein T cell T cell epitope T cell epitopes T cell response T cells target the SARS-CoV-2 Vaccination strategies Vaccine Vaccine design Vaccine development virus
[DOI] 10.3389/fimmu.2020.587615 PMC 바로가기 [Article Type] Immunology

T‐cell responses and therapies against SARS‐CoV‐2 infection

SARS-CoV-2 감염에 대한 T 세포 반응 및 치료법

Review

Published on 2020-10-272022-09-10
Journal: Immunology [Category] MERS, SARS, 치료제,

[키워드] activating addition Antiviral antiviral immune response antiviral immunity blockers caused Combination contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Cytokines disease drug effective failure Immune checkpoint inhibitor Immune checkpoint inhibitors immune response immune responses IMPROVE include individuals initial initial stages Novel coronavirus outcomes Pathogenesis progression SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Spike protein Stage systemic inflammation T cell T cells T‐cell T‐cell response T‐cell responses Th1 Th17 the spike protein Therapeutic approach Therapies therapy tissue damage treat Vaccine Viral viral infection
[DOI] 10.1111/imm.13262 PMC 바로가기 [Article Type] Review

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses
[DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article

T cell immunity to SARS-CoV-2 following natural infection and vaccination

Article

Published on 2020-10-232023-06-15
Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS,

[키워드] COVID-19 Infection SARS-CoV-2 T cells vaccination
[DOI] 10.1016/j.bbrc.2020.10.060 PMC 바로가기 [Article Type] Article

T cell regeneration after immunological injury

Reviews

Published on 2020-10-232022-10-05
Journal: Nature reviews. Immunology [Category] 바이오마커,

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

HIV-1 프로테아제의 약물 내성 관련 돌연변이 중 양성 상위성의 우세

Research Article

Published on 2020-10-212022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] alleviate antiretroviral drug antiretroviral drugs Author capture clinic clinical observation clinical observations Clinical studies clinical study clinically Combination combinations compensatory mutations deep sequencing Deleterious deleterious effect deleterious effects drug drug resistance Effect epistasis Evolution fitness Genetic genetic interactions greatly reduce HIV HIV-1 Impact in vitro inhibitors Interaction interactions involved likelihood long term majority mechanism mutant Mutation mutations observation outcome overcome pandemic patients persistence positive Prophylaxis protease Protease inhibitor protease inhibitors reduce Replication resistance mutations reversal reversion selection experiments sequence Support T cells therapy Viral viral genome viral replication
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article

Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients

Article

Published on 2020-10-192022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술,

Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case Severity

Microbiology

Published on 2020-10-162022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] abundantly expressed Bronchoalveolar lavage fluid Care cell infection rate cells Clinical outcome COVID-19 COVID-19 case COVID-19 patients death detectable differentially expressed event expression feature fusion Health immune implicated infected cell joint macrophages moderate motif NK cells nucleocapsid ORF10 outbreak outcome pathogenesis of COVID-19 Patient patients with moderate predict Predictive progression reported resource RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequence severe cases severe COVID-19 severe patients significantly higher Single Cell T cells the disease the patient the SARS-CoV-2 The United States tissue trajectory transcription regulatory sequence Transcriptome TRS TRSs viral fusion evolution viral gene expression viral transcript virulence Virus evolution virus gene fusion
[DOI] 10.3389/fmicb.2020.603509 PMC 바로가기 [Article Type] Microbiology

Unique immunological profile in patients with COVID-19

COVID-19 환자의 독특한 면역 프로필

Clinical Trial

Published on 2020-10-152022-08-13
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19
[DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial