Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
파파인 유사 프로테아제는 SARS-CoV-2 바이러스 확산 및 선천 면역을 조절합니다
Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Antiviral
antiviral immune response
antiviral immunity
attenuate
biochemical
cleavage
cleave
cleaving
complex
contribute
coronavirus
crystal structure
cytopathogenic effect
domain
dual
enzyme
functional
generate
high affinity
highlight
highlighting
Host
host protein
host proteins
immune responses
impair
implicated
infected cells
Infection
Innate immunity
Interaction
interactions
interferon
interferon pathway
interferon-stimulated gene
IRF3
ISG15
maintain
mechanism
NF-κB
NF-κB pathways
Papain-like protease
PLPro
polyprotein
post-translational modification
promote
protease
Protein
reduce
regulate
Regulation
required
respiratory
responses
reveal
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 viral
sequence identity
severe acute respiratory syndrome Coronavirus
specificity
Spread
suppress
target
therapeutic strategy
type I interferon
ubiquitin
Viral
viral replication
viral spread
[DOI] 10.1038/s41586-020-2601-5 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41586-020-2601-5 PMC 바로가기 [Article Type] Article