Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic OriginsArticle Published on 2015-03-122022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 2G12 activities activity acute respiratory syndrome AGOR analyses Antigen antigens ASOR carbohydrate carbohydrate microarrays characterized conserved coronavirus epitope Epitopes Express Galanthus genomic GlcNAc glycan glycosylation GNA HCMV high-density highlight HIV-1 Host Human Cytomegalovirus Human monoclonal antibody identifying include information Man Microarray moiety molecular basis molecular target neutralize oligomannoses origin Phylogenetic probes profile Progress Protein target reactive recognize SARS-CoV sugar moieties sugar moiety target targeting Vaccine viral pathogens virus virus Virus neutralization virus-neutralizing virus-neutralizing antibody [DOI] 10.3390/molecules20034610 PMC 바로가기 [Article Type] Article
Proteome Profile of Swine Testicular Cells Infected with Porcine Transmissible Gastroenteritis CoronavirusResearch Article Published on 2014-10-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Alpha Analysis analyzed approach biological processes caspase-8 Cell cells cellular change complex conducted coronavirus determine developmental expression expression level Extracellular matrix gastroenteritis growth growth factor Heat shock help host cell immune system Infection Interaction knowledge maturation mechanism metabolite neurological system occur Ontology Pathogenesis post infection precursor profile Protein protein complex protein level Proteins proteomic provide quantitation Quantitative Signaling significant changes in Stage Stress Testicular TGEV TGF-β1 two-dimensional viral infection virus Virus-host interactions Western blot analysis [DOI] 10.1371/journal.pone.0110647 PMC 바로가기 [Article Type] Research Article
Prevalence and Genetic Diversity Analysis of Human Coronavirus OC43 among Adult Patients with Acute Respiratory Infections in Beijing, 2012Research Article Published on 2014-07-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Acute respiratory infection addition Amino acid Analysis ARI assays Beijing circulating Cluster coding region collected Consensus described determine Diversity epidemiological Epidemiology Evidence genetic diversity HCoV-OC43 Human coronavirus human coronavirus OC43 Infection N gene nasopharyngeal swab sample OC43 occurred Partial Patient patients patients with ARI Phylogenetic Phylogenetic analysis polymerase chain Prevalence profile respiratory reverse transcription RT-PCR sequence sequenced strain the epidemic the patient unique [DOI] 10.1371/journal.pone.0100781 PMC 바로가기 [Article Type] Research Article
DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4 + T-Cell Population StructureDNA 메틸화는 건강한 대조군과 알레르기 환자를 분리하고 변경된 CD4 + T-세포 집단 구조를 반영할 수 있습니다.Research Article Published on 2014-01-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allergen allergic allergic rhinitis allergy alteration Altered approach assumed Author blood cell CD4 cells change changes in compared Control controls different disease DNA DNA methylation Epigenetic epigenomics etiology Evidence explain found Gene Expression gene expression profile Gene expression profiles healthy control healthy controls healthy individual healthy individuals heterogeneity highlight humans Illumina immune in vitro model individuals infectious agent infectious agents Inflammatory diseases life mechanism memory Methylation Microarrays molecular Patient PBMC PBMCs phenotype Population profile proportion proportions psoriasis purified SAR seasonal Seasonal allergic rhinitis Separate separation Stratification Structure subtype Support T cells T-cell T-cells White blood cell [DOI] 10.1371/journal.pgen.1004059 PMC 바로가기 [Article Type] Research Article
Molecular Networks of Human Muscle Adaptation to Exercise and Age운동과 나이에 대한 인간 근육 적응의 분자 네트워크Research Article Published on 2013-03-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 13q21 1q12 activated all-trans-retinoic acid Activation adaptation age Ageing all-trans-retinoic acid alteration Analysis applicability aryl-hydrocarbon receptor signaling ATRA Author chance chromosomal Cohort cohorts component Compound continuum contributed developmental processe developmental processes Differential analysis displaying DNA topoisomerase down-regulation driven by EET endurance exercise endurance exercise training Epigenetic events exercise exhibited found Gain Gene gene-expression gene-networks gene-set gene-sets generate Genes growth Health care Health care system health care systems Human hypertrophic response hypertrophic responses hypertrophy identify Impact independent individual individuals Ingenuity Pathway Analysis inhibited Interaction IPA lean mass life loci Longevity mimicking molecular molecular network molecular networks mTOR muscle muscle age muscle growth Musculoskeletal network Older overlap pathway phenotype physical activity post-transcriptional processe post-transcriptional processes profile proportion Quality of life Rapamycin reduced referred to regulated related resistance-exercise training RET retinoic acid ribosomal genes rising risk RNA signature RNA signatures rRNAs RXR sarcopenia sarcopenic Serotonin Signaling significantly Society stream subject topoisomerase transcript unique Z-score [DOI] 10.1371/journal.pgen.1003389 PMC 바로가기 [Article Type] Research Article
Approaching the Functional Annotation of Fungal Virulence Factors Using Cross-Species Genetic Interaction Profiling종간 유전적 상호작용 프로파일링을 사용하여 진균 독성 인자의 기능적 주석 접근Research Article Published on 2012-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accurate AIDS analyzed annotation approach Author C. neoforman C. neoformans C. neoformans gene C. neoformans genes calculation Cancer Cell cell surface Chemotherapy compared conserved correlated correlation correlations Cryptococcus neoforman Cryptococcus neoformans death deletion mutant deletion mutants demonstrated develop disease enhancement expressed expression Factor found function functional functional annotation fungal fungal pathogens fungi Gene gene deletion gene function Genetic genetic interaction genetic interactions Golgi Golgi apparatus growth HIV/AIDS HIV/AIDS patients human pathogen identify immunostimulatory individuals Infection inhibiting Interaction interactions lack mannose molecular mutant Organ transplant organism Organisms ortholog pathogen pathogenicity pathogenicity protein Pathogens patients phagocytosis predict predicted profile profiles Profiling promote quantification Quantitative recipient required S. cerevisiae Saccharomyces cerevisiae sequence supported suppression susceptible tested the cell understanding utility validation virulence virulence gene yeast [DOI] 10.1371/journal.pgen.1003168 PMC 바로가기 [Article Type] Research Article
Etiology and Clinical Characterization of Respiratory Virus Infections in Adult Patients Attending an Emergency Department in BeijingResearch Article Published on 2012-02-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addressed Adult assay Attending Beijing characterization checked China clinical clinical symptom conducted Department detected determine different dominant effective Emergency epidemiological finding HCoV-229E Health highlight human coronavirus influenza virus métapneumovirus nose parainfluenza pathogen Patient picornavirus polymerase chain positive Prevalence profile real-time RT-PCR reported respiratory respiratory syncytial virus respiratory tract infection respiratory virus Respiratory virus infection respiratory viruses reverse transcription RSV Safe significantly tested therapeutic approach throat swab virus virus virus infection viruses [DOI] 10.1371/journal.pone.0032174 PMC 바로가기 [Article Type] Research Article
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compoundsShort Communication Published on 2004-05-182022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] acute respiratory syndrome antiviral activity antiviral agent Antiviral compound Antiviral compounds assay cell line cell lines Checkerboard Chinese Combination Compound different drug Epidemics glycyrrhizin interferon interferon-alpha isolate neutralisation test performed placebo controlled trial plaque reduction assays profile Prophylaxis randomised Result ribavirin SARS Coronavirus screened selected Severe acute respiratory syndrome susceptibility synergistic synergy Toxicity Treatment [DOI] 10.1016/j.jcv.2004.03.003 PMC 바로가기 [Article Type] Short Communication