Warp-Speed Covid-19 Vaccine Development: Beneficiaries of Maturation in Biopharmaceutical Technologies and Public-Private PartnershipsWarp-Speed Covid-19 백신 개발: 바이오제약 기술 및 민관 파트너십 성숙의 수혜자Article Published on 2021-02-012022-08-31 Journal: Journal of pharmaceutical sciences [Category] MERS, SARS, 신약개발, [키워드] activity anticipated approach approval beneficiary biopharmaceutical Biopharmaceutics Biotechology candidate clinical study clinical testing COVID-19 current develop Disease progression dose effective effective vaccine Effective vaccines Formulation Gene therapy Human immune response Infection less majority masking measure operation organized partnership platform Prevent resource Safe SARS-CoV2 service social distancing speed Stage supported sustained technology vaccine candidate Vaccines while [DOI] 10.1016/j.xphs.2020.11.010 PMC 바로가기 [Article Type] Article
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다Article Published on 2021-02-012022-09-11 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19 [DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article
Dandelion and focal crazy paving signs: the lung CT based predictors for evaluation of the severity of coronavirus diseaseArticle Published on 2021-02-012023-07-12 Journal: Current medical research and opinion [Category] SARS, [키워드] COVID-19 Dandelion sign focal crazy paving sign. SARS-CoV2 [DOI] 10.1080/03007995.2020.1846173 PMC 바로가기
Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: A position paper on behalf of the SIGENP IBD working groupReview Published on 2021-02-012023-07-06 Journal: Digestive and liver disease : official journal of [Category] SARS, [키워드] COVID-19 Inflammatory bowel disease paediatrics SARS-CoV2 [DOI] 10.1016/j.dld.2020.10.024 PMC 바로가기 [Article Type] Review
Managing Multimorbidity (Multiple Chronic Diseases) Amid COVID-19 Pandemic: A Community Based Study From Odisha, IndiaArticle Published on 2021-02-012023-06-14 Journal: Frontiers in Public Health [Category] MERS, [키워드] Comorbidity Health care access long standing health conditions MAQ-COVID19 multiple morbidities multiple NCD management pandemic SARS-CoV2 [DOI] 10.3389/fpubh.2020.584408 PMC 바로가기
Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?폭풍과의 싸움: 새로운 항-TNFα 및 항-IL-6 C. sativa 품종이 COVID-19의 사이토카인 폭풍을 길들일 수 있습니까?Research Paper Published on 2021-01-312022-08-31 Journal: Aging (Albany NY) [Category] 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome addition aging anti-IL-6 anti-inflammatory effect Anti-inflammatory effects anti-inflammatory regimen approach ARDS autoinflammatory disease Cancer cannabis cascade CCL2 cell line complications conditions COVID-19 COVID-19 cytokine storm COVID-19 disease COVID-19 patient COVID-19 patients COX2 cytokine Cytokine storm Cytokines death Deleterious disease disease severity down-regulation downregulate effective Escalation expression fibroblast fibrosis Fighting frailty Gene Expression had no IL-6 include induce Inflammation Inflammatory Inflammatory cytokine Initially involved lead leads lung Lung fibrosis medical cannabis modulate molecular MOST no effect novel Pathogenesis pathway Pathways Prevent pro-inflammatory cytokine pro-inflammatory cytokines proinflammatory cytokines respiratory distress responsible rheumatological SARS-CoV2 Seven severe COVID-19 disease syndrome target tested therapeutic These data tissue tissues TNFα TNFα treat treated Treatment [DOI] 10.18632/aging.202500 PMC 바로가기 [Article Type] Research Paper
Immunomodulation for the management of severe SARS-CoV2 infections. State of the art and review of the literatureReview Published on 2021-01-292023-07-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, [키워드] COVID-19 Cytokine storm immunomodulation SARS-CoV2 Tocilizumab [DOI] 10.1016/j.bbrc.2020.11.084 PMC 바로가기 [Article Type] Review
Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity인간 ACE2 결합 친화도가 변경된 SARS-CoV2 스파이크 단백질의 돌연변이를 설명하는 진화적 및 구조적 분석Article Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] 변종, [키워드] ACE2 ACE2 binding affinity Alter Analysis analyzed binding binding affinity binding energy binding free energy docking Efficacy ENhance evaluate facilitate FIVE free energy Free energy calculations G476S glycoprotein host cell human ACE2 hydrogen Hydrogen bond identify Mutation pandemic Population Population variants Positive selection Proteomic analysis RBD RBD variant RBD variants RBD-ACE2 Receptor-binding domain Recognition reduced residue reveal SARS-CoV2 SARS-CoV2 genome Selection Selection bias spike spike glycoprotein Spike protein spike variant Structural analysis the RBD the receptor-binding domain V367F V483A variant variations while Wuhan [DOI] 10.1016/j.bbrc.2021.01.035 PMC 바로가기 [Article Type] Article
Perspectives of Antidiabetic Drugs in Diabetes With Coronavirus InfectionsPharmacology Published on 2021-01-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome agonist antidiabetic antidiabetic agents Comorbidity complex controls coronavirus Coronavirus infection COVID-19 diabete Diabetes Mellitus Dipeptidyl peptidase-4 DPP4 drug Evidence glycemic increase individual Infection inhibitors insulin management Patient peptide receptor reported risk SARS-CoV2 subjects therapeutic therapeutic choices therapy viral infection [DOI] 10.3389/fphar.2020.592439 PMC 바로가기 [Article Type] Pharmacology
Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potentialHost-Microbe Interactions Published on 2021-01-292022-10-28 Journal: Bioscience Reports [Category] COVID-19, [키워드] bind binding binding site conserved COVID-19 COVID-19 pandemic COVID19 determinant determine develop Effect effective expressed help Human immune system Hypothesis ICAM-1 immune Immune cell integrin Interaction leukocyte leukocytes LFA1 Mac1 Macrophage macrophages molecular docking ORF7a orf7a protein predict Protein provide receptor required SARS-CoV2 structural homology T lymphocyte the disease [DOI] 10.1042/BSR20203837 PMC 바로가기 [Article Type] Host-Microbe Interactions