Does Circulating Antibody Play a Role in the Protection of Piglets against Porcine Epidemic Diarrhea Virus?Research Article Published on 2016-04-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 24 hour Administered administration ameliorated Analysis antibody Antibody Response antibody transfer assigned body temperature circulating circulating antibody Clinical signs collected colostrum contribute contributed demonstrated Effect epidemic diarrhea evaluated experiment faster fecal fecal samples group growth IgA IgG Infection infections inoculated intraperitoneally naïve Neonatal PCR PEDV protection provided Randomized real-time reverse transcriptase remained returned role secretory IgA serum antibody suggested Survivability survival TCID tested Treatment virus virus-neutralizing antibody [DOI] 10.1371/journal.pone.0153041 PMC 바로가기 [Article Type] Research Article
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis PneumoniaHIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할Research Article Published on 2016-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load [DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article
Role of the lipid rafts in the life cycle of canine coronavirusStandard Published on 2015-02-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] Antiviral Antiviral strategies canine cell entry cell membrane cell membranes cholesterol complex Concentration coronavirus Coronaviruses disrupt dose-dependent dose-dependent reduction enveloped RNA virus host cells in viral Infection infection rate infections inhibitory inhibitory effect involved Lipid lipid composition lipid metabolism mechanism membrane modulate plasma membrane Protein Proteins reduction in required role sphingolipids Treatment viral entry viral particle virus virus infectivity was reduced was used [DOI] 10.1099/vir.0.070870-0 PMC 바로가기 [Article Type] Standard
An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding천연 단백질 폴딩에서 마이코박테리아 DnaK의 필수 비중복 역할Research Article Published on 2014-07-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a minor absence accompanied accumulation aggregate antibiotic Bacterial pathogens bacterium Cell cell growth cells cellular chaperone chaperones characterized daughter cells Degradation denaturation Disruption domain E. coli Essential examined expand expression Factor foci genus growth heat Host Hsp70 identify include insoluble lack less life Loss membrane minor mycobacteria mycobacterial Mycobacterium Native organism paradigm Pathogens peptide peptides Prevent Protein protein folding Protein misfolding Proteins redundancy required role solubility stationary stationary phase Stress susceptibility synthases translation Trigger unique viability [DOI] 10.1371/journal.pgen.1004516 PMC 바로가기 [Article Type] Research Article
Role of Transportation in Spread of Porcine Epidemic Diarrhea Virus Infection, United StatesDispatch Published on 2014-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Cornaviridae biosecurity Epidemic epidemic diarrhea fomite hygiene lairage measure PEDV Porcine epidemic diarrhea virus role tested the United State Transmission Transport transported United State virus viruses [DOI] 10.3201/eid2005.131628 PMC 바로가기 [Article Type] Dispatch
Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases온대 파지는 이완된 상동 재조합에 의해 결함 있는 프로파지로부터 DNA를 획득한다: Rad52-유사 재조합효소의 역할Research Article Published on 2014-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addressed Bacteria Bacterial bacterial virus bacterial viruses bacteriophage bacteriophages Bioinformatics analysis biosphere catalyzed comparison complementary contribute defective prophages dependent on Divergence DNA dormant dormant state E. coli Efficiency element Escherichia coli Evidence evidence of Evolution exchange functions gene exchange gene exchanges gene transfer Genetic genetic determinant genetic determinants genetic diversity genetic exchanges Genome genomes genomic Homologous recombination homologous recombination enzymes horizontal gene Horizontal gene transfer Hypothesis in vivo Infection lambdoid phage lambdoid phages majority mechanism molecular mechanisms mosaicism no evidence of phage phage encoded recombinase phage encoded recombinases phage gene phage genome phage λ phages phenotype promote prophage prophages Rad52 RecA REcombinase recombinases Recombination replicate role sequence sequence homology sequences subject Temperate bacteriophage Temperate bacteriophages temperate phage temperate phages transfer virulence virulent virulent phages viruses vivo assays [DOI] 10.1371/journal.pgen.1004181 PMC 바로가기 [Article Type] Research Article
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article