Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article
Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibodyArticle Published on 2015-09-152022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] antibody binding complex Critical domain epitope Fab healthy high affinity Human implication in vivo information Interaction m336 mechanism MERS-CoV Mortality Mutation neutralization overlap provide residue reveal structural biology supplementary material Vaccine development vaccine immunogen viral infection virus Virus structures [DOI] 10.1038/ncomms9223 PMC 바로가기 [Article Type] Article
Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27Article Published on 2015-08-182022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis antibody assist binding binding site biochemical carbohydrate cause Critical DPP4 epitope Fab fragment Human Human monoclonal antibody inhibit interact Interaction membrane fusion MERS-CoV MERS-CoV infection MERS-CoV RBD Middle East molecular basis mortality rate neutralization neutralization activity overlap RBD receptor Receptor binding Receptor binding domain reported residue residues respiratory syndrome coronavirus severe respiratory illness spike glycoprotein the RBD viral entry [DOI] 10.1038/srep13133 PMC 바로가기 [Article Type] Article
Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013Research Article Published on 2015-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accumulated Amino acid amino acid substitution Analysis analyzed antigenic caused change Characteristics characterization characterized China Chinese Complete contagious death diarrhea Effectiveness epidemic diarrhea epitope Genetic Genetic variation Genome genome sequence hydrophilicity identify identity less Multiple Mutation N gene Neutralizing nucleotide ORF1a/b ORF3 outbreak PEDV proximal ranged S gene strain Strains structural protein unique Vaccine viral disease virus viruses vomiting watery [DOI] 10.1371/journal.pone.0120310 PMC 바로가기 [Article Type] Research Article
Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic OriginsArticle Published on 2015-03-122022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 2G12 activities activity acute respiratory syndrome AGOR analyses Antigen antigens ASOR carbohydrate carbohydrate microarrays characterized conserved coronavirus epitope Epitopes Express Galanthus genomic GlcNAc glycan glycosylation GNA HCMV high-density highlight HIV-1 Host Human Cytomegalovirus Human monoclonal antibody identifying include information Man Microarray moiety molecular basis molecular target neutralize oligomannoses origin Phylogenetic probes profile Progress Protein target reactive recognize SARS-CoV sugar moieties sugar moiety target targeting Vaccine viral pathogens virus Virus neutralization virus-neutralizing virus-neutralizing antibody [DOI] 10.3390/molecules20034610 PMC 바로가기 [Article Type] Article
Prediction of common epitopes on hemagglutinin of the influenza A virus (H1 subtype)Article Published on 2015-02-012023-06-25 Journal: Experimental and molecular pathology [Category] 신종인플루엔자, [키워드] Blocking experiments Computer simulation prediction epitope flu Influenza virus monoclonal antibody [DOI] 10.1016/j.yexmp.2014.12.005
An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2Article Published on 2014-09-012023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] docking epitope influenza A virus Interaction nucleoprotein Replication vRNP complex. [DOI] 10.1016/j.virol.2014.06.033
Substitution at Aspartic Acid 1128 in the SARS Coronavirus Spike Glycoprotein Mediates Escape from a S2 Domain-Targeting Neutralizing Monoclonal AntibodyResearch Article Published on 2014-07-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid addition Alanine Amino acid antigenic bind binding Cell epitope escape etiological agent exhibited expression humans in vitro infect Infectious disease Interaction Lip mAb mAbs monoclonal antibody murine mutant Mutation neutralization Neutralizing neutralizing antibody no effect overcome Particles Prevent Protein pseudotyped residue respiratory S protein S2 subunit SARS-CoV SARS-CoV infection SARS-like CoV shown significant decrease SL-CoVs spike Substitution surface Spike the S protein viral entry virion virus wild-type wild-type virus zoonotic [DOI] 10.1371/journal.pone.0102415 PMC 바로가기 [Article Type] Research Article
A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine designResearch Article Published on 2014-05-292022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, [키워드] 100% conserved Antigen approach can be used Consensus conserved coronavirus coronavirus disease coronavirus strains epitope human coronavirus identify immunogenic in silico in vivo include Infection membrane MERS-CoV Multiple nucleocapsid outbreak peptide polyprotein predict Prevent prevention Protein Result RNA RNA directed RNA polymerase RNA polymerase RNA virus SARS-CoV sequence strain Strains Universal vaccine Vaccine Vaccine design virus [DOI] 10.1186/1471-2105-15-161 PMC 바로가기 [Article Type] Research Article
Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates인간, 생쥐 및 인간이 아닌 영장류에 효과적인 보편적인 CD4 기억 T 세포 회상 펩타이드의 생성journal-article Published on 2014-05-012024-07-30 Journal: Vaccine [Category] 파상풍, [키워드] antibodies epitope memory T cell nanoparticle Vaccine [DOI] 10.1016/j.vaccine.2014.02.024 [Article Type] journal-article